Inhibitory effects of daidzein on intestinal motility in normal and high contractile states

Chen, Dapeng; Xiong, Yongjian; Tang, Ze-Yao; Lv, Bochao; Lin, Yuan

doi:10.3109/13880209.2012.698285

Cited by 5 publications

(1 citation statement)

References 18 publications

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“…Depending on the experiment, either the duodenum and ileum (about 2 cm long), and/or trachea were excised. Intestinal portions were individually mounted in organ baths containing constantly oxygenated Tyrode solution (20 mL, pH 8.2) at 37ºC (Emendorfer et al 2005;Ragone et al 2007;Chen et al 2012;Matera et al 2016).…”

Section: Isolation Of Smooth Muscles Preparations and Contractile Meamentioning

confidence: 99%

Antitussive, antispasmodic, bronchodilating and cardiac inotropic effects of the essential oil from Blepharocalyx salicifolius leaves

Hernández

Ragone

Bonazzola

et al. 2018

Journal of Ethnopharmacology

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The results indicate that the preparations from Blepharocalyx salicifolius leaves were effective as central antitussive, bronchodilating and antispasmodic agents, suggestive of a mechanism associated with the inhibition of Ca influx into smooth muscle. The EO-Bs displayed only a poor ability to reduce cardiac inotropism, and was devoid of any cardioprotective properties. Thus, the present study validates the traditional use of this South American plant for asthma, cough and bronchospasm, shedding new light into its potency and putative mechanism of action.

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Section: Isolation Of Smooth Muscles Preparations and Contractile Meamentioning

confidence: 99%

Antitussive, antispasmodic, bronchodilating and cardiac inotropic effects of the essential oil from Blepharocalyx salicifolius leaves

Hernández

Ragone

Bonazzola

et al. 2018

Journal of Ethnopharmacology

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Effects of ginsenoside Re on rat jejunal contractility

Xiong

Chen

et al. 2014

J Nat Med

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Ginsenoside Re (GRe) exerts diverse effects. Based on our observations, the present study was designed to investigate GRe-exerted bidirectional regulation (BR) on the contractility of isolated jejunal segment. Six pairs of different low and high contractile states of rat jejunal segment were established and used in the study. Stimulatory effects on the contractility of jejunal segment were exerted by GRe (10.0 μM) in all 6 low contractile states, and inhibitory effects were exerted in all 6 high contractile states, indicating that GRe exerted BR on the contractility of jejunal segment. The effects of GRe on the phosphorylation of 20 kDa myosin light chain, protein contents of myosin light chain kinase (MLCK) and MLCK mRNA expression in jejunal segment in low and high contractile states were also bidirectional. GRe-exerted BR was abolished in the presence of neurotoxin tetrodotoxin or Ca2+ channel blocker verapamil or c-Kit receptor tyrosine kinase inhibitor imatinib. Atropine blocked the stimulatory effects of GRe on jejunal contractility in low-Ca2+-induced low contractile state; phentolamine, propranolol and l-NG-nitro-arginine blocked the inhibitory effects in high-Ca2+-induced high contractile state, respectively. In summary, GRe-exerted BR depends on jejunal contractile state and requires the presence of enteric nervous system, Ca2+, and interstitial cells of Cajal; the stimulatory effects of GRe on jejunal contractility are related to cholinergic stimulation and inhibitory effects are related to adrenergic activation and nitric oxide relaxing mechanisms.

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Soy Isoflavones and Gastrointestinal Health

Al‐Nakkash

Kubinski

2020

Curr Nutr Rep

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Inhibitory effects of daidzein on intestinal motility in normal and high contractile states

Cited by 5 publications

References 18 publications

Antitussive, antispasmodic, bronchodilating and cardiac inotropic effects of the essential oil from Blepharocalyx salicifolius leaves

Antitussive, antispasmodic, bronchodilating and cardiac inotropic effects of the essential oil from Blepharocalyx salicifolius leaves

Effects of ginsenoside Re on rat jejunal contractility

Soy Isoflavones and Gastrointestinal Health

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