Soy Isoflavones and Gastrointestinal Health

Al‐Nakkash, Layla; Kubinski, Aaron

doi:10.1007/s13668-020-00314-4

Cited by 18 publications

(8 citation statements)

References 49 publications

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“…Genistein acts directly as an ERβ agonist, whereas daidzein can be converted by the gut bacteria of some individuals to S-equol, a compound that likewise acts as a selective ERβ agonist at physiological concentrations (64)(65)(66). Consistent with these findings, soy isoflavone administration has been found to promote a healthy intestinal barrier in rodent studies (67,68).…”

Section: Soy Isoflavones Aid Intestinal Barrier Function Via Erβmentioning

confidence: 70%

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function

McCarty

Lerner

2021

Advances in Nutrition

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Impairment of intestinal barrier function is linked to certain pathologies and to aging, and can be a cause of bacterial infections, systemic and hepatic inflammation, food allergies, and autoimmune disorders. The formation and maintenance of intestinal tight junctions is supported by glucagon-like peptide-2 (GLP-2), which via insulin-like growth factor I activity boosts phosphoinositide 3-kinase/Akt/mammalian target of rapamycin complex 1 (PI3K/Akt/mTORC1) signaling in enterocytes. 5′-AMP-activated protein kinase (AMPK) activity as well as estrogen receptor-β (ERβ) activity are also protective in this regard. Conversely, activation of mitogen-activated protein kinases (MAPKs) and cellular Src (c-Src) under inflammatory conditions can induce dissociation of tight junctions. Hence, nutraceuticals that promote GLP-2 secretion from L cells—effective pre/probiotics, glycine, and glutamine—as well as diets rich in soluble fiber or resistant starch, can support intestinal barrier function. AMPK activators—notably berberine and the butyric acid produced by health-promoting microflora—are also beneficial in this regard, as are soy isoflavones, which function as selective agonists for ERβ. The adverse impact of MAPK and c-Src overactivation on the intestinal barrier can be combatted with various antioxidant measures, including phycocyanobilin, phase 2–inducer nutraceuticals, and N-acetylcysteine. These considerations suggest that rationally designed functional foods or complex supplementation programs could have clinical potential for supporting and restoring healthful intestinal barrier function.

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Section: Soy Isoflavones Aid Intestinal Barrier Function Via Erβmentioning

confidence: 70%

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function

McCarty

Lerner

2021

Advances in Nutrition

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“…This result further confirmed that fermented soymilk has an antioxidant and intestinal inflammation preventive effects. Considering the antioxidant effect of isoflavones, polyphenols, and active peptides in soybean and the ability of soy isoflavones and small molecule peptides to effectively relieve the symptoms of UC (55,56), we speculated that the effect of fermented soymilk on preventing colitis in mice is closely related to the antioxidant activities of fermented soymilk. Besides, our previous work also showed that soybean β-conglycinin peptides (SGP) could promote the proliferation of Caco-2 cells, enhance the formation of intercellular tight junctions, and have a potential antiinfective ability (57).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant properties of fermented soymilk and its anti-inflammatory effect on DSS-induced colitis in mice

Sun

Zhao

et al. 2023

Front. Nutr.

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Lactic acid-fermented soymilk as a new plant-based food has aroused extensive attention because of its effects on nutrition and health. This study was conducted to delve into the antioxidative and anti-inflammatory activities of lactic acid-fermented soymilk. To elucidate the key factors that affect the antioxidant properties of fermented soymilk, the strains and preparation process were investigated. Findings show that the fermented soymilk prepared using hot-water blanching method (BT-80) demonstrated a better antioxidant activity than that using conventional method (CN-20). Besides, a huge difference was observed among the soymilks fermented with different strains. Among them, the YF-L903 fermented soymilk demonstrated the highest ABTS radical scavenging ability, which is about twofold of that of unfermented soymilk and 1.8-fold of that of L571 fermented soy milk. In vitro antioxidant experiments and the analysis of H2O2-induced oxidative damage model in Caco-2 cells showed that lactic acid-fermentation could improve the DPPH radical scavenging ability, ABTS radical scavenging ability, while reducing the content of reactive oxygen species (ROS) and malondialdehyde (MDA) in Caco-2 cells induced by H2O2, and increasing the content of superoxide dismutase (SOD). Consequently, cells are protected from the damage caused by active oxidation, and the repair ability of cells is enhanced. To identify the role of fermented soymilk in intestinal health, we investigate its preventive effect on dextran sodium sulfate-induced colitis mouse models. Results revealed that the fermented soymilk can significantly improve the health conditions of the mice, including alleviated of weight loss, relieved colonic injury, balanced the spleen-to-body weight ratio, reduced the disease index, and suppressed the inflammatory cytokines and oxidant indexes release. These results suggest that YF-L903 fermented soymilk is a promising natural antioxidant sources and anti-inflammatory agents for the food industry. We believe this work paves the way for elucidating the effect of lactic acid-fermented soymilk on intestinal health, and provides a reference for the preparation of fermented soymilk with higher nutritional and health value.

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“…Bioactive substances in LAB‐fermented soymilk, like soy protein and soy isoflavones, can limit intestinal morphological damage and enhance the epithelial barrier function, alleviating UC development. [ 39 ] Consistently, FSM4 could play a role in mucosal barrier integrity, promoting intestinal health.…”

Section: Discussionmentioning

confidence: 99%

Exploring Impact of Probiotic‐Fermented Soymilk on Dextran‐Sulfate‐Sodium‐Induced Ulcerative Colitis via Modulating Inflammation and Gut Microbiota Profile

Madjirebaye,

Peng,

Mueed

et al. 2024

Molecular Nutrition Food Res

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ScopeLactic acid bacteria with probiotic functions and their fermentation products play a role in regulating ulcerative colitis (UC). This study investigates the potential role of fermented soymilk (FSM4) rich in isoflavones on DSS‐induced UC.Methods and ResultsMice received 3% DSS and are supplemented daily once for 1 week by NFSM and FSM4. DSS usually causes intestinal inflammation and alters the gut microbiota. FSM4 intervention improves the UC‐related inflammation and gut microbiota alteration. It considerably decreases pro‐inflammatories such as TNF‐α, IL‐1β, and IL‐6 in serum and COX‐2 and MPO in colon tissues and pathogenic bacteria (Escherichia‐Shigella). This facilitates gut‐healthy bacteria growth. These healthy bacteria negatively correlat with pro‐inflammatory factors but positively associated with acetic acid, butyric acid, and propionic acid, which may act for PPAR‐γ pathway activating and NF‐κB p65 pathway inhibiting, lowering the risk of UC. Overall, FSM4 might alleviate UC and significantly reverse the dysbiosis of gut microbiota via the PPAR‐γ activation. It could be a good alternative for developing functional food to protect against UC.ConclusionFSM4 attenuates intestinal inflammation and modulates the SCFA‐producing bacteria growth, which enable the PPAR‐γ activation to alleviate the UC target, which could be a dietary intervention strategy for gut health.

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Soy Isoflavones and Gastrointestinal Health

Cited by 18 publications

References 49 publications

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function

Antioxidant properties of fermented soymilk and its anti-inflammatory effect on DSS-induced colitis in mice

Exploring Impact of Probiotic‐Fermented Soymilk on Dextran‐Sulfate‐Sodium‐Induced Ulcerative Colitis via Modulating Inflammation and Gut Microbiota Profile

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