Inhibitory effects of Dai-saiko-to (Da-Chai-Hu-Tang) on the progression of atherosclerotic lesions in Kurosawa and Kusanagi-hypercholesterolemic rabbits

Suppressive Effect of Cocoa Powder on Atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic Rabbits

“…Inverse correlation between intake of antioxidants and cardiovascular diseases were shown in epidemiological studies (1)(2)(3). In FH model animals such as WHHL rabbits and KHC rabbits, natural antioxidative substances like vitamin E (30) and taurine (31), herbal medicines containing flavonoid (32,33), and hypocholesterolemic agent possessing antioxidative activity, probucol (34,35) were reported to suppress development of atherosclerosis. These antioxidative substances exert anti-atherosclerotic effect without decreasing plasma cholesterol.…”

Evaluation of Oxygen Radical Absorbance Capacity in Kampo Medicine

“…For example, in examination using KHC rabbit, which is a model of the familial hypercholesterolemia, the development of arteriosclerosis was inhibited by the dosage of choijokito of 1 g kg −1 of 24 weeks [10]. Although daisaikoto did not improve hypercholesterolemia in KHC rabbits, it restrained the development of arteriosclerosis in the aorta and showed an antioxidant capacity for the LDL [11]. In addition, in the study using the same model, san'oshashinto made the use rate of α -tocopherol high, and had antioxidant capacity for the LDL, although it did not give a change to serum lipid [12].…”

Evaluation of Rhubarb using antioxidative activity as an index of pharmacological usefulness

“…(Mian et al, 1987;Yokozawa et al, 1996). We previously reported that some herbal prescriptions containing Rhubarb inhibit the development of atheromatous plaque formation through antioxidative effects on low-density lipoprotein (LDL) in a spontaneous familial hypercholesterolemia model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits (Iizuka et al, 1998(Iizuka et al, , 2000.…”