Evaluation of Rhubarb using antioxidative activity as an index of pharmacological usefulness

Iizuka, Akira; Iijima, Osamu T.; Kondo, Kazuo; Itakura, Hiroshige; Yoshie, Fumihiko; Miyamoto, Hiroko; Kubo, Masayoshi; Higuchi, Masahiko; Takeda, Hiroshi; Matsumiya, Teruhiko

doi:10.1016/j.jep.2003.11.021

Cited by 74 publications

(38 citation statements)

References 12 publications

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“…Nowadays, anthraquinones attracted attention especially related to their interesting biological properties. They are known for their different biological activities including antimicrobial 13 , anticancer 14 , antioxidant 15 and anti-inflammatory 16 . In this direction, it is suggested that consumption of anthraquinones-rich plants such as Rhamnus and Frangula species [17][18][19] can represent a valid intake way in order to benefit of their biological activities.…”

Section: Introductionmentioning

confidence: 99%

Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eightAsphodelinetaxa from Turkey: canAsphodelineroots be considered as a new source of natural compounds?

Zengin

Locatelli

Ceylan

2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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Plant-based foods have become attractive for scientists and food producers. Beneficial effects related to their consumption as dietary supplements are due to the presence of natural occurring secondary metabolites. In this context, studies on these products are important for natural and safely food ingredients evaluation. The aim of this study was to evaluate root extract of eight Asphodeline species as antioxidants, enzyme inhibitors and phytochemical content. Spectrophotometric antioxidant and enzyme inhibitory assays were performed. Total phenolic and flavonoids contents as well as the chemical free-anthraquinones profiles were determined using routinely procedure (HPLC-PDA). Data show that Asphodeline roots can be considered as a new source of natural compounds and can be used as a valuable dietary supplement. Some differences related to biological activities can be inferred to other phytochemicals that can be considered in the future for their synergic or competitive activities.

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Section: Introductionmentioning

confidence: 99%

Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eightAsphodelinetaxa from Turkey: canAsphodelineroots be considered as a new source of natural compounds?

Zengin

Locatelli

Ceylan

2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…In rhubarb, anthraquinone derivatives [emodin, chrysophanol, rhein, aloe-emodin, and physcion ( Fig. 1) and their glucosides] are thought to be the major active components, having many different biological and pharmacological properties such as antioxidant [7], antibacterial [8], antiviral [9], antifungal [10], antiatherosclerotic [11], and anticancer activities [12]. Due to their biological effects, increasing attention is being paid to these compounds.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial properties of anthraquinones extracted from rhubarb against Aeromonas hydrophila

Wang

et al. 2011

Fish Sci

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Antibacterial properties of crude extract from rhubarb and its major bioactive compounds against Aeromonas hydrophila were assayed. Major bioactive compounds (anthraquinone derivatives) in rhubarb collected from different cultivation areas were determined by ultraperformance liquid chromatography (UPLC); the antibacterial activity [minimum inhibitory concentration (MIC)] of rhubarb was positively related to the anthraquinone content (r = 0.9306, P \ 0.01). The MIC values of five anthraquinones against A. hydrophila were found to be in the range 50-200 lg/ml. Action-mode studies showed that anthraquinones (emodin) inhibits cellular functions by binding to cell DNA after penetrating the cell membrane, resulting in cell death. The present study suggests that anthraquinones extracted from rhubarb have potential use as antimicrobials for control of A. hydrophila.

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“…Anthroquinones are study of attention due to their extensive range of applications (Mueller et al, 1999). Anthraquinones derivatives are confirmed to possess numerous biological activities such as anti-inflammatory (Gautam et al, 2010), antifungal (Agarwal et al, 2000), antioxidant (Iizuka et al, 2004), anticancer (Zhou et al, 2006), and genotoxicity and antigenotoxicity (Mueller et al, 1999). The diverse medicinal applications of genus Rumex have prompted us to investigate the constituents of R.…”

Section: Introductionmentioning

confidence: 99%

Two new antioxidant anthraquinones namely Obtusifolate A and B from Rumex obtusifolius

2017

Int. J. Biosci.

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According to folk medicine Rumex obtusifolius 's root has a prominent detoxifying result on the liver and is used against fever, jaundice, and as an anti-anemic tonic. The roots are laxative and the leaves of this Rumex are used against hepatic, dermatological and eye problems. The diverse medicinal applications of R. obtusifolius and its genus have prompted us to investigate the constituents of the said plant. In bio-guided isolation Two new anthraquinones namely sec-butyl 1, 8-dihydroxy-5-methyl-3-(4'-(5''methylbut-4''-enoyl)-2'-(2''oxopropyl)-6-tert-pentyl-anthraquinone-2-carboxylate (Obtusifolate A) and methyl 1, 8-dihydroxy-5-methyl-3-(2'methyl-4'-(2''methylbut-1''-enoyl)-6-tert-pentyl-anthraquinone-2-carboxylate (Obtusifolate B) were isolated from Rumex obtusifolius. Their structures were identified by chemical and modern spectroscopic techniques i.e. 1 H and 13 C NMR, UV, IR and mass spectrometry. Both the compounds showed excellent antioxidant activities in the DPPH radical scavenging assay. Our findings provide evidence that R. obtusifolius is a potent source of natural antioxidants, and thus justified its uses in folkloric medicines.

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Evaluation of Rhubarb using antioxidative activity as an index of pharmacological usefulness

Cited by 74 publications

References 12 publications

Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eightAsphodelinetaxa from Turkey: canAsphodelineroots be considered as a new source of natural compounds?

Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eightAsphodelinetaxa from Turkey: canAsphodelineroots be considered as a new source of natural compounds?

Antibacterial properties of anthraquinones extracted from rhubarb against Aeromonas hydrophila

Two new antioxidant anthraquinones namely Obtusifolate A and B from Rumex obtusifolius

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