Inhibitory Effects of Brazilian Propolis on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis

Yasukawa,

doi:10.6000/1927-5951.2012.02.01.10

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…In fact, there was a complete removal or absence of dermal edema in 9 out of 10 carrageenan-injected mice in both pre-treated groups relative to those of the distilled water-treated counterpart. The same observation was reported by Yasukawa et al [59], Bolfa et al [60], and Jastrzebska-Stojko et al [61] using Brazilian, Romanian, and Polish propolis, respectively. However, the extent of dermal edema formation especially in the distilled water-treated control group, which yielded an output that was only indicative of a mild grade, was rather unexpected.…”

Section: Discussionsupporting

confidence: 85%

Attenuation of carrageenan-induced hind paw edema and plasma TNF-α level by Philippine stingless bee (<i>Tetragonula biroi</i> Friese) propolis

et al. 2021

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Despite decades-long existence of the Philippine stingless bee industry, the biological activity of propolis from this native bee species (Tetragonula biroi Friese) remains poorly understood and sparingly investigated. Herein, we examined the potential anti-inflammatory efficacy of Philippine stingless bee propolis using the lambda (λ)-carrageenan-induced mice model of hind paw edema. Thirty (30), sixweek-old, male ICR mice were randomly assigned into three treatment groups (n=10/group) as follows: distilled water group, diclofenac sodium group (10 mg/kg), and propolis group (100mg/kg). All treatment were administered an hour prior to the injection of the phlogistic agent. As observed at 3 hours post-injection, λ-carrageenan remarkably evoked the classical signs of hind paw edema exemplified grossly by swelling and hyperemia. The ameliorative effect of propolis became apparent at the onset of 6 hours post-injection with a statistically significant finding evident at the 24hour period. This gross attenuation histologically correlated to a considerable and specific reduction of the dermal edema, which mirrored those of the diclofenac sodium group. Furthermore, both propolis and diclofenac sodium significantly attenuated the λ-carrageenan-induced increase in the protein expression levels of the pro-inflammatory cytokine TNF-α depicting more than twofold decrement relative to the distilled water group. Altogether, these suggest that Philippine stingless bee propolis also exhibited a promising in vivo anti-inflammatory property, which can be partly mediated through the inhibition of TNF-α.

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Section: Discussionsupporting

confidence: 85%

Attenuation of carrageenan-induced hind paw edema and plasma TNF-α level by Philippine stingless bee (<i>Tetragonula biroi</i> Friese) propolis

et al. 2021

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“…As can be seen in Table 1 By comparison with methanol extracts of supplemental foods on tumour promotion, Canadian goldenrod flower was similar in activity to poria [5], safflower [6], galangal [7], Brazilian propolis [8], gymnema [9], and seabuckthorn [10].…”

Section: Resultsmentioning

confidence: 88%

Inhibitory Effects of the Flower of Canadian Goldenrod (Solidago altissima L.) on Tumour Promotion Induced by 12-O-tetradecanoylphorbol-13-actete

Yasukawa

2015

J. Nutr. Ther.

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Cancer prevention is an important issue in various healthcare fields; thus, we continue searching for potential useful compounds. This study focuses on the utilization of Canadian goldenrod, which is commonly seen growing on vacant land. Methanol extracts of the flower of Canadian goldenrod inhibited inflammation by 12-Otetradecanoylphorbol-13-acetate (TPA) and inhibited promotion in the mouse skin two-stage carcinogenesis model. Five inhibitory compounds were isolated from the active fraction, and these compounds were identified as flavonoids; kaempferol (1), quercetin (2), kaempferol-3-O-rutinoside (3), querectin-3-O-rutinoside (4), and isorhamnetin-3-Orutinoside (5). These compounds inhibited the inflammation induced by TPA, and the inhibitory effects were similar to indomethacin.

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“…Eight triterpenes were identified and main compounds of this fraction were tirucallene derivatives masticadienoic acid (7‐tirucallene derivative, 23%) and isomasticadienoic acid (8‐tirucallene derivative, 19%) followed by oleanonic acid (12‐oleanene derivative, 10%) and moronic acid (18‐oleanene derivative, 2.4%), which have all M + 468 and were identified in the acidic fraction according to their main fragments. Moronic acid and its derivatives have been object of several studies on their pharmacological application showing in silico , in vitro and in vivo antidiabetic activity (Cerón‐Romero et al, ; Ramirez‐Espinosa et al, ; Ramírez‐Espinosa et al, ), antitmural potential (Rios, Salinas, & Villarreal, ; Yasukawa, Yu, Tsutsumi, Kurokawa, & Park, ) and antiviral effects (Ito et al, ; Kurokawa et al, ; Qian et al, ). Multitarget activities of masticadienonic acid were found against chronic and acute inflammation (Dzubak et al, ).…”

Section: Resultsmentioning

confidence: 99%

GC–MS analysis of terpenes from Sicilian Pistacia vera L. oleoresin. A source of biologically active compounds

Napoli

Gentile

Ruberto

2018

Biomedical Chromatography

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The genus Pistacia includes different species diffused worldwide able to produce oleoresins used in several folk medicines. Oleoresins are phytocomplexes exudate from the trunk of plants and possess several biological properties thanks to the simultaneous presence of essential oils, di-and triterpenes and phenols. Pistacia vera L. oleoresin chemical composition is not well known owing a lack of studies compared with other Pistacia species. The aim of this work was to report the terpenes profile of this phytocomplex collected in Sicily (Italy) by means of GC-FID and GC-MS analysis of its essential oil and less volatile fractions. Results show that this profile is peculiar and different from the other Pistacia species mainly in terms of relative percentages of its components. α-Pinene is the main compound of the essential oil, while dammarane and tirucallene derivatives are the main triterpenes identified in the less volatile fractions. This work represents the first complete terpenoidic chemical profile of the oleoresin of P. vera L. and should be considered as a first step for a deeper evaluation of biological properties and future application of this phytocomplex.

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Inhibitory Effects of Brazilian Propolis on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis

Cited by 11 publications

References 23 publications

Attenuation of carrageenan-induced hind paw edema and plasma TNF-α level by Philippine stingless bee (<i>Tetragonula biroi</i> Friese) propolis

Attenuation of carrageenan-induced hind paw edema and plasma TNF-α level by Philippine stingless bee (<i>Tetragonula biroi</i> Friese) propolis

Inhibitory Effects of the Flower of Canadian Goldenrod (Solidago altissima L.) on Tumour Promotion Induced by 12-O-tetradecanoylphorbol-13-actete

GC–MS analysis of terpenes from Sicilian Pistacia vera L. oleoresin. A source of biologically active compounds

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