Inhibitory Effects of 1,2,3,4,6-Penta-
 O
 -Galloyl-β-
 <scp>d</scp>
 -Glucopyranose on Biofilm Formation by
 Staphylococcus aureus

Lin, Mei-Hui; Chang, Fang Rong; Hua, Mu Yi; Wu, Yang; Liu, Shih Tung

doi:10.1128/aac.00843-10

Cited by 76 publications

(77 citation statements)

References 40 publications

(36 reference statements)

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“…Pentagalloyl glucose (one of the major components of commercial tannic acid) and ellagic acid (another plant-derived polyphenolic compound) have also been shown to inhibit biofilm formation in S. aureus (46,47). To the best of our knowledge, no genetic mechanism for the antibiofilm properties of tannic acid or related polyphenols in S. aureus has been proposed.…”

Section: Discussionmentioning

confidence: 97%

Tannic Acid Inhibits Staphylococcus aureus Surface Colonization in an IsaA-Dependent Manner

et al. 2013

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Staphylococcus aureus is a human commensal and pathogen that is capable of forming biofilms on a variety of host tissues and implanted medical devices. Biofilm-associated infections resist antimicrobial chemotherapy and attack from the host immune system, making these infections particularly difficult to treat. In order to gain insight into environmental conditions that influence S. aureus biofilm development, we screened a library of small molecules for the ability to inhibit S. aureus biofilm formation. This led to the finding that the polyphenolic compound tannic acid inhibits S. aureus biofilm formation in multiple biofilm models without inhibiting bacterial growth. We present evidence that tannic acid inhibits S. aureus biofilm formation via a mechanism dependent upon the putative transglycosylase IsaA. Tannic acid did not inhibit biofilm formation of an isaA mutant. Overexpression of wild-type IsaA inhibited biofilm formation, whereas overexpression of a catalytically dead IsaA had no effect. Tannin-containing drinks like tea have been found to reduce methicillin-resistant S. aureus nasal colonization. We found that black tea inhibited S. aureus biofilm development and that an isaA mutant resisted this inhibition. Antibiofilm activity was eliminated from tea when milk was added to precipitate the tannic acid. Finally, we developed a rodent model for S. aureus throat colonization and found that tea consumption reduced S. aureus throat colonization via an isaA-dependent mechanism. These findings provide insight into a molecular mechanism by which commonly consumed polyphenolic compounds, such as tannins, influence S. aureus surface colonization.

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Section: Discussionmentioning

confidence: 97%

Tannic Acid Inhibits Staphylococcus aureus Surface Colonization in an IsaA-Dependent Manner

et al. 2013

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“…6 S. aureus within biofilms has a better capability of withstanding nutrient deprivation, oxygen radicals, and antibiotics than their planktonic counterpart. 25 Due to the difficulty of eliminating the biofilm on the surface, biofilm infection attracts much attention in the medical world.…”

Section: Discussionmentioning

confidence: 99%

“…1 The ability of formation of biofilm by S. aureus is closely associated with its capacity to produce an extracellular mucous substance, polysaccharide intercellular adhesion (PIA). 6 The main component of PIA is glycosaminoglycans. 7 PIA provides the biofilm with a stable structure, helps the bacteria to adhere to material surfaces, and protects the bacteria embedded in it from being killed by the immune system or antibiotics.…”

Section: Introductionmentioning

confidence: 99%

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Reduced Staphylococcus aureus biofilm formation in the presence of chitosan-coated iron oxide nanoparticles

Shi

Jia

Guo³

et al. 2016

IJN

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Abstract:Staphylococcus aureus can adhere to most foreign materials and form biofilm on the surface of medical devices. Biofilm infections are difficult to resolve. The goal of this in vitro study was to explore the use of chitosan-coated nanoparticles to prevent biofilm formation. For this purpose, S. aureus was seeded in 96-well plates to incubate with chitosan-coated iron oxide nanoparticles in order to study the efficiency of biofilm formation inhibition. The biofilm bacteria count was determined using the spread plate method; biomass formation was measured using the crystal violet staining method. Confocal laser scanning microscopy and scanning electron microscopy were used to study the biofilm formation. The results showed decreased viable bacteria numbers and biomass formation when incubated with chitosan-coated iron oxide nanoparticles at all test concentrations. Confocal laser scanning microscopy showed increased dead bacteria and thinner biofilm when incubated with nanoparticles at a concentration of 500 µg/mL. Scanning electron microscopy revealed that chitosan-coated iron oxide nanoparticles inhibited biofilm formation in polystyrene plates. Future studies should be performed to study these nanoparticles for anti-infective use.

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“…It has been demonstrated that administration of herbal medicine in Thailand turned out to inhibit biofilm formation by S. epidermidis. 38 Also been observed that herbs have antibacterial activity and antibiofilm that can be an alternative to combat pathogenic microorganisms, particularly S. epidermidis. 39 In addition of antibacterial activity and antibiofilm, has been studied about medicinal plants againts on S. epidermidis biofilms.…”

Section: Discussionmentioning

confidence: 99%

Efficcacy of Lantana camara Linn. leaf extracts ointment on dermal wound healing were infected with Staphylococcus epidermidis

Parwanto

2017

Int J Basic Clin Pharmacol

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Background: Dermal infections by Staphylococcus epidermidis can cause problems for patients. Antibiotic resistance have been reported to treat the bacteria, therefore need to develop new drugs, among others sourced from herbs. For this purpose, study is needed to find an efficacy of Lantana camara Linn. leaf extract ointment on dermal wound healing were infected with S. epidermidis.Methods: Wistar rats divided into 4 groups randomly. Group I=dermal wounded, infected with S. epidermidis, untreated. Group II=dermal wounded, infected with S. epidermidis, treated with L. camara Linn. leaf extract ointment 5%. Group III=dermal wounded, infected with S. epidermidis, treated with L. camara Linn. leaf extract ointment 10%. Group IV=dermal wounded, infected with S. epidermidis, treated with sodium fusidate 2%. Bacterial colonies number observed on 6 days, while the quality of wound healing, measurement of DNA and protein levels on 6, 14 and 18 days. Mean ± SD between groups were analyzed by ANOVA.Results: Wound healing in group II qualitatively better than group I, III and IV. Bacterial colonies number in group II was lower than groups I, III and IV (p<0.05), whereas DNA and protein levels was higher in group II compare to groups I, III and IV (p<0.05). On 6, 14 and 18 days observations there are trend similarly ie DNA levels decreased, conversely protein levels increased.Conclusions: L. camara Linn. leaf extract ointment 5% more effective than 10% on dermal wound healing.

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Inhibitory Effects of 1,2,3,4,6-Penta- O -Galloyl-β- d -Glucopyranose on Biofilm Formation by Staphylococcus aureus

Cited by 76 publications

References 40 publications

Tannic Acid Inhibits Staphylococcus aureus Surface Colonization in an IsaA-Dependent Manner

Tannic Acid Inhibits Staphylococcus aureus Surface Colonization in an IsaA-Dependent Manner

Reduced <em>Staphylococcus aureus</em> biofilm formation in the presence of chitosan-coated iron oxide nanoparticles

Efficcacy of Lantana camara Linn. leaf extracts ointment on dermal wound healing were infected with Staphylococcus epidermidis

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