Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts

Lü, Yuan; Wang, W.-J.; Leng, Jinhua; Cheng, Lijian; Feng, Lei; Yao, Hang‐Ping

doi:10.1007/s00011-007-7128-9

Cited by 21 publications

(9 citation statements)

References 29 publications

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“…Triptolide with 100 ng/ml concentration could inhibit inflammatory cytokine production of FLS and inhibit invasive capacities of FLS. Lu et al (2008) demonstrated that triptolide inhibits the expression of IL-18 and its receptor in PMA-stimulated FLSs in a dose-dependent manner by suppressing NF-κB activity. However, Lu et al (2008) only analyzed one inflammatory cytokine produced by FLS.…”

Section: Potential Effects Of Triptolide On Inflammatory Diseasesmentioning

confidence: 97%

“…Lu et al (2008) demonstrated that triptolide inhibits the expression of IL-18 and its receptor in PMA-stimulated FLSs in a dose-dependent manner by suppressing NF-κB activity. However, Lu et al (2008) only analyzed one inflammatory cytokine produced by FLS. Lin et al (2001) demonstrated that 28–140 nM triptolide suppresses the production of proMMP1 and 3 in IL-1α-induced FLSs.…”

Section: Potential Effects Of Triptolide On Inflammatory Diseasesmentioning

confidence: 97%

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Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review

Yuan

et al. 2019

Front. Pharmacol.

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Bioactive compounds from medicinal plants with anti-inflammatory and immunosuppressive effects have been emerging as important sources of drugs for the treatment of inflammatory disorders. Triptolide, a diterpene triepoxide, is a pharmacologically active compound isolated from Tripterygium wilfordii Hook F (TwHF) that is used as a remedy for inflammatory and autoimmune diseases. As the most promising bioactive compound obtained from TwHF, triptolide has attracted considerable interest recently, especially for its potent anti-inflammatory and immunosuppressive activities. Over the past few years, an increasing number of studies have been published emphasizing the value of triptolide in the treatment of diverse inflammatory disorders. Here, we systematically review the mechanism of action and the therapeutic properties of triptolide in various inflammatory diseases according to different systematic organs, including lupus nephritis, inflammatory bowel disease, asthma, and rheumatoid arthritis with pubmed and Embase. Based on this review, potential research strategies might contribute to the clinical application of triptolide in the future.

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Section: Potential Effects Of Triptolide On Inflammatory Diseasesmentioning

confidence: 97%

Section: Potential Effects Of Triptolide On Inflammatory Diseasesmentioning

confidence: 97%

Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review

Yuan

et al. 2019

Front. Pharmacol.

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“…Conversely, the expression of tissue inhibitors of metalloproteinases (TIMPs) 1 and 2 induced by IL-1α was augmented by TP in the synovial cells [ 44 ]. In phorbol 12-myristate 13-acetate (PMA)-stimulated RA, the expression of IL-18 and IL-18 receptor (IL-18R) at protein and gene levels FLSs were also reduced by TP [ 45 ].…”

Section: Effect and Mechanisms Of Triptolide (Tp) In Rheumatoid Armentioning

confidence: 99%

The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation

Fan

Guo

Shen

et al. 2018

IJMS

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Triptolide (TP), a major extract of the herb Tripterygium wilfordii Hook F (TWHF), has been shown to exert potent pharmacological effects, especially an immunosuppressive effect in the treatment of rheumatoid arthritis (RA). However, its multiorgan toxicity prevents it from being widely used in clinical practice. Recently, several attempts are being performed to reduce TP toxicity. In this review, recent progress in the use of TP for RA, including its pharmacological effects and toxicity, is summarized. Meanwhile, strategies relying on chemical structural modifications, innovative delivery systems, and drug combinations to alleviate the disadvantages of TP are also reviewed. Furthermore, we also discuss the challenges and perspectives in their clinical translation.

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“…In recent years, triptolide has been shown to exert excellent anti-inflammatory effects as an RA treatment (Peng et al, 2014; Fan et al, 2016). Among these studies, RA-FLS were identified as one of the main targets of triptolide for RA therapy (Lin et al, 2001, 2008; Kusunoki et al, 2004; Shao et al, 2004; Yao et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Atomic Force Microscopy Study of the Anti-inflammatory Effects of Triptolide on Rheumatoid Arthritis Fibroblast-like Synoviocytes

Sun

et al. 2017

Microsc Microanal

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High-resolution atomic force microscopy (AFM) was used for the in situ evaluation of the anti-inflammatory effects of triptolide on rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) to understand the anti-RA effects of triptolide, based on the morphological and biophysical changes observed in RA-FLS. RA-FLS have been reported to play a primary role in inflammatory bone destruction during the development of RA and thus are regarded as an important target for RA treatment. Triptolide pretreatment significantly inhibited tumor necrosis factor-α-induced expression of the interleukin (IL)-1β, IL-6, and IL-8 genes in MH7A cells. Using AFM, we showed that triptolide-induced morphological damage in MH7A cells by inducing significant ultrastructure changes in the membrane, which were closely related to triptolide-induced apoptosis in MH7A cells. Using force measurements determined with AFM, triptolide was shown to increase the stiffness of MH7A cells. These findings not only revealed the strong anti-inflammatory effects of triptolide on RA-FLS, highlighting triptolide as a potential anti-RA agent, but also revealed the possible use of AFM for studying anti-inflammatory responses in RA-FLS, which we expect to be developed into a potential tool for anti-RA drug studies in RA-FLS.

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Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts

Abstract: TP effectively inhibited the expression of IL-18 and its receptor in PMA-stimulated RASF. These results suggest a mechanism of TP in RA therapy.

Cited by 21 publications

References 29 publications

Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review

Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases—A Review

The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation

Atomic Force Microscopy Study of the Anti-inflammatory Effects of Triptolide on Rheumatoid Arthritis Fibroblast-like Synoviocytes

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