Inhibitory Effect of Tetrandrine on Lens Proteins-Induced Ocular Inflammation in Rabbits

Xiao, Jianzhong; Wang, Yoliang; Shuyang, Wu; Jing-ge, LI; Zhang, Shuping

doi:10.1089/jop.1992.8.309

Cited by 11 publications

(7 citation statements)

References 3 publications

(6 reference statements)

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“…The lens cells in the anterior chamber also worsen the development of the anterior segment and can delay eye development in general. Moreover, the crystallins in the anterior chamber might induce ocular inflammation and glaucoma ( 50 , 51 ). During this embryonic stage (E15.5) and the early postnatal period (P10) before eye opening, genes representing inflammation markers such as IL-1β and TNF-α are significantly up-regulated suggesting that congenital ocular inflammation occurs.…”

Section: Discussionmentioning

confidence: 99%

Peroxidasin is essential for eye development in the mouse

Yan

Sabrautzki²,

Horsch³

et al. 2014

Human Molecular Genetics

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Mutations in Peroxidasin (PXDN) cause severe inherited eye disorders in humans, such as congenital cataract, corneal opacity and developmental glaucoma. The role of peroxidasin during eye development is poorly understood. Here, we describe the first Pxdn mouse mutant which was induced by ENU (N-ethyl-N-nitrosourea) and led to a recessive phenotype. Sequence analysis of cDNA revealed a T3816A mutation resulting in a premature stop codon (Cys1272X) in the peroxidase domain. This mutation causes severe anterior segment dysgenesis and microphthalmia resembling the manifestations in patients with PXDN mutations. The proliferation and differentiation of the lens is disrupted in association with aberrant expression of transcription factor genes (Pax6 and Foxe3) in mutant eyes. Additionally, Pxdn is involved in the consolidation of the basement membrane and lens epithelium adhesion in the ocular lens. Lens material including γ-crystallin is extruded into the anterior and posterior chamber due to local loss of structural integrity of the lens capsule as a secondary damage to the anterior segment development leading to congenital ocular inflammation. Moreover, Pxdn mutants exhibited an early-onset glaucoma and progressive retinal dysgenesis. Transcriptome profiling revealed that peroxidasin affects the transcription of developmental and eye disease-related genes at early eye development. These findings suggest that peroxidasin is necessary for cell proliferation and differentiation and for basement membrane consolidation during eye development. Our studies provide pathogenic mechanisms of PXDN mutation-induced congenital eye diseases.

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Section: Discussionmentioning

confidence: 99%

Peroxidasin is essential for eye development in the mouse

Yan

Sabrautzki²,

Horsch³

et al. 2014

Human Molecular Genetics

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“…Thus, inhibition of IL-1 release and IL-1 receptor should be able to result in an effective and potent suppression of inflammation without producing the serious side effects produced by steroids, NSAIAs, and PAF antagonists (9). It was reported that prostaglandin and leukotriene generation were inhibited by Tet (4,14) which suppressed the release of two major metabolites of arachidonic acid, namely the leukotriene B4 (LTB4) and the thromboxane B2 (TXB2). This was catalyzed by calmodulin-dependent phospholipase A2 (PLA2) from the membrane phospholipids (15).…”

Section: Discussionmentioning

confidence: 99%

“…In previous publications (4,5), we have reported that Tet is able to inhibit uveitis induced by lens-proteins and bovine serum albumin without producing ocular hypertension and withdrawal rebound which are frequently induced by steroids in rabbits.…”

mentioning

confidence: 89%

Tetrandrine Inhibits Breakdown of Blood-Aqueous Barrier Induced by Endotoxin and Interleukin-1α in Rats

Xiao¹,

Chiou²

1996

Journal of Ocular Pharmacology and Therapeutics

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Tetrandrine was shown to significantly inhibit uveitis induced by endotoxin and interleukin-1 alpha (IL-1 alpha) in rats. The dose-response curve of IL-1 alpha-induced uveitis was inhibited in a non-competitive manner. The maximum inflammation induced by IL-1 alpha was suppressed to 58.4%, 38.3% and 18.3% of the control peak by 5 mg/kg, 10 mg/kg and 20 mg/kg t.i.d. of tetrandrine, respectively. The maximum inflammation induced by endotoxin was suppressed to 56.5% and 38.0% by 5 mg/kg and 10 mg/kg t.i.d. of tetrandrine, respectively. The mechanism of tetrandrine's anti-inflammation could involve numerous pathways of inflammation processes and multiple inflammatory mediators. The results of this study indicate that tetrandrine appears to be a broad spectrum, non-steroidal, novel ocular anti-inflammatory agent.

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Section: Effects Of Natural Products On Ocular Inflammationmentioning

confidence: 99%

“…As an anti-inflammatory agent, tetrandrine was shown to block the ocular inflammation induced by lens proteins, bovine serum albumin, endotoxin, and IL-1 (30,31). It was reported that tetrandrine inhibited the generation of leukotriene B4 and thromboxane B2, a prostaglandin, in the arachidonate cascade (31,32). Tetrandrine was also able to suppress microvascular leakage and other inflammatory processes induced by PAF and other allergic mediators (33) and to inhibit the capacity of human mononuclear leukocyte's and monocyte's production of TNFa and lymphocyte's release of TNF/3 (34,35).…”

Section: Effects Of Natural Products On Ocular Inflammationmentioning

confidence: 99%

Review Effects of Chinese Herbal Products on Mammalian Retinal Functions

Liu

Chiou²

1996

Journal of Ocular Pharmacology and Therapeutics

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Ocular ischemia and inflammation are two major factors which induce retinal degeneration. Treatment of these diseases has been difficult, though numerous agents have been tried. Natural products could be a good field to venture into because various medicinal plants have been used for centuries to treat circulation stasis, inflammation, visual disturbances, and eyesight failure. Tetramethyl-pyrazine, coumarin, methyl tyramine, rescinnamine, apocynin, and hesperetin are some natural products isolated from Chinese herbs for improving ocular blood flow, particularly in the choroid and retina. For ocular inflammation, at least a dozen natural products are reviewed in this article. Among those, matrine, tetrandrine and osthole draw particular attention, because they are effective mainly as interleukin-1 blockers, but not as arachidonate blockers. As a result, these agents are potent anti-inflammatory agents and are even more potent than the prototype corticosteroid, prednisolone. It is hoped that all aforementioned agents can be used to treat retinopathies resulting from ocular ischemia and/or ocular inflammation. Scoparone, corylifolinin, epigallocatechin-3-0-gallate, esculetin, and lespedezaflavanone A are some natural products which can improve retinal functions measured with electroretinogram's b-wave recovery. Further research should be carried out to relate natural products which can improve ocular blood flow and inflammation to retinal function and vice versa.

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Inhibitory Effect of Tetrandrine on Lens Proteins-Induced Ocular Inflammation in Rabbits

Cited by 11 publications

References 3 publications

Peroxidasin is essential for eye development in the mouse

Peroxidasin is essential for eye development in the mouse

Tetrandrine Inhibits Breakdown of Blood-Aqueous Barrier Induced by Endotoxin and Interleukin-1α in Rats

Review Effects of Chinese Herbal Products on Mammalian Retinal Functions

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