Tetrandrine Inhibits Breakdown of Blood-Aqueous Barrier Induced by Endotoxin and Interleukin-1α in Rats

Abstract

Tetrandrine was shown to significantly inhibit uveitis induced by endotoxin and interleukin-1 alpha (IL-1 alpha) in rats. The dose-response curve of IL-1 alpha-induced uveitis was inhibited in a non-competitive manner. The maximum inflammation induced by IL-1 alpha was suppressed to 58.4%, 38.3% and 18.3% of the control peak by 5 mg/kg, 10 mg/kg and 20 mg/kg t.i.d. of tetrandrine, respectively. The maximum inflammation induced by endotoxin was suppressed to 56.5% and 38.0% by 5 mg/kg and 10 mg/kg t.i.d. of tetrandrine, respectively. The mechanism of tetrandrine's anti-inflammation could involve numerous pathways of inflammation processes and multiple inflammatory mediators. The results of this study indicate that tetrandrine appears to be a broad spectrum, non-steroidal, novel ocular anti-inflammatory agent.

Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-κB activation

“…TET exerted a profound inhibitory effect on T cell activation in vivo, as reported in various systems by several groups. TET has been found to reduce the severity of adjuvant-induced arthritis in rats, and to inhibit interleukin-1␤ or endotoxin-induced uveitis [31,32]. Our observations of the beneficial effects of TET on CIH were consistent with previous studies.…”

Suppression of Interleukin-1α-Induced Uveitis and Inhibition of Fibroblast-like Cell Proliferation by Synthetic Interleukin-1 Blockers

“…Numerous agents, including natural products and synthetic compounds, have been found to block IL-la-induced uveitis (23)(24)(25)(26)(27)(28)(29)(30)(31). These agents include tetrandrine (23), chalcone derivatives (24,25), osthole (26), and synthetic organic CK-compounds (27)(28)(29)(30)(31).…”

“…These agents include tetrandrine (23), chalcone derivatives (24,25), osthole (26), and synthetic organic CK-compounds (27)(28)(29)(30)(31). Among the natural products, tetrandrine is the only one with acceptable safety, or least toxicity (23). Most of them are too toxic to be useful clinically.…”

Correlation of antioxidative properties and vaso-relaxation effects of major active constituents of traditional Chinese medicines

“…Salidroside (from Rhokiola rosea) has been used to treat cancer, scalds, anoxia and reduced blood glucose (Qu, 2005). Tetrandrine (from Stephania tetrandra) has been used to treat cardiac arrhythmia, angina and inflammation (Liu et al, 1995;Wang & Lemos, 1995;Xiao & Chiou, 1996).…”