Inhibitory Effect of Taurine on Biofilm Formation During Alkane Degradation in Acinetobacter oleivorans DR1

Eom, Hyo Jung; Park, Woojun

doi:10.1007/s00248-017-1010-2

Cited by 15 publications

(7 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These pro-inflammatory metabolisms stimulated B. sp LM24 to metabolise the antiperoxidases hydroxyanigorufone (hydroxyanisone), D-erythroascorbic acid, and 1′-a-D-xylopyranoside. They were significantly up-regulated, which was consistent with other studies wherein bacteria usually produced several antioxidant substances to alleviate oxidative damage in cells [ 37 , 38 , 39 , 40 ].…”

Section: Resultssupporting

confidence: 91%

Metabolic Mechanism of Bacillus sp. LM24 under Abamectin Stress

Zhu

Xie

et al. 2023

IJERPH

View full text Add to dashboard Cite

Abamectin (ABM) has been recently widely used in aquaculture. However, few studies have examined its metabolic mechanism and ecotoxicity in microorganisms. This study investigated the molecular metabolic mechanism and ecotoxicity of Bacillus sp. LM24 (B. sp LM24) under ABM stress using intracellular metabolomics. The differential metabolites most affected by the bacteria were lipids and lipid metabolites. The main significant metabolic pathways of B. sp LM24 in response to ABM stress were glycerolipid; glycine, serine, and threonine; and glycerophospholipid, and sphingolipid. The bacteria improved cell membrane fluidity and maintained cellular activity by enhancing the interconversion pathway of certain phospholipids and sn-3-phosphoglycerol. It obtained more extracellular oxygen and nutrients to adjust the lipid metabolism pathway, mitigate the impact of sugar metabolism, produce acetyl coenzyme A to enter the tricarboxylic acid (TCA) cycle, maintain sufficient anabolic energy, and use some amino acid precursors produced during the TCA cycle to express ABM efflux protein and degradative enzymes. It produced antioxidants, including hydroxyanigorufone, D-erythroascorbic acid 1′-a-D-xylopyranoside, and 3-methylcyclopentadecanone, to alleviate ABM-induced cellular and oxidative damage. However, prolonged stress can cause metabolic disturbances in the metabolic pathways of glycine, serine, threonine, and sphingolipid; reduce acetylcholine production; and increase quinolinic acid synthesis.

show abstract

Section: Resultssupporting

confidence: 91%

Metabolic Mechanism of Bacillus sp. LM24 under Abamectin Stress

Zhu

Xie

et al. 2023

IJERPH

View full text Add to dashboard Cite

show abstract

“…Moreover, the important functional role of the tauRXYPI cluster, implicated in taurine metabolism in A. calcoaceticus, has been analyzed under nitrogen limitation conditions (143). The inhibitory effect of taurine on the formation of biofilm during alkane degradation was recently studied and shows that taurine probably affects the alkaneinduced cell surface (144).…”

Section: Energy Metabolismmentioning

confidence: 99%

Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments

et al. 2018

View full text Add to dashboard Cite

SUMMARYPathogens that infect the gastrointestinal and respiratory tracts are subjected to intense pressure due to the environmental conditions of the surroundings. This pressure has led to the development of mechanisms of bacterial tolerance or persistence which enable microorganisms to survive in these locations. In this review, we analyze the general stress response (RpoS mediated), reactive oxygen species (ROS) tolerance, energy metabolism, drug efflux pumps, SOS response, quorum sensing (QS) bacterial communication, (p)ppGpp signaling, and toxin-antitoxin (TA) systems of pathogens, such as , spp., spp., spp., , spp., spp., spp., and , all of which inhabit the gastrointestinal tract. The following respiratory tract pathogens are also considered:, ,, , and Knowledge of the molecular mechanisms regulating the bacterial tolerance and persistence phenotypes is essential in the fight against multiresistant pathogens, as it will enable the identification of new targets for developing innovative anti-infective treatments.

show abstract

“…To adhere to lipophilic Hex, the bacterial cell surface becomes hydrophobic, creating a hydrophobic environment between the cell and the substrate (23,24). This may make it difficult for polar substrates such as ions and water to enter the cells (25).…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Bacterial Alkanesulfonate Monooxygenase under Oxidative Stress

Park

Shin

Park

2020

Appl Environ Microbiol

Self Cite

View full text Add to dashboard Cite

Bacterial alkane metabolism is associated with a number of cellular stresses, including membrane stress and oxidative stress, and the limited uptake of charged ions such as sulfate. In the present study, the genes ssuD and tauD in Acinetobacter oleivorans DR1 cells, which encode an alkanesulfonate monooxygenase and a taurine dioxygenase, respectively, were found to be responsible for hexadecanesulfonate (C16SO3H) and taurine metabolism, and Cbl was experimentally identified as a potential regulator of ssuD and tauD expression. The expression of ssuD and tauD occurred under sulfate-limited conditions generated during n-hexadecane degradation. Interestingly, expression analysis and knockout experiments suggested that both genes are required to protect cells against oxidative stress, including that generated by n-hexadecane degradation and H2O2 exposure. Measurable levels of intracellular hexadecanesulfonate were also produced during n-hexadecane degradation. Phylogenetic analysis suggested that ssuD and tauD are mainly present in soil-dwelling aerobes within the Betaproteobacteria and Gammaproteobacteria classes, which suggests that they function as controllers of the sulfur cycle and play a protective role against oxidative stress in sulfur-limited conditions. IMPORTANCE ssuD and tauD, which play a role in the degradation of organosulfonate, were expressed during n-hexadecane metabolism and oxidative stress conditions in A. oleivorans DR1. Our study confirmed that hexadecanesulfonate was accidentally generated during bacterial n-hexadecane degradation in sulfate-limited conditions. Removal of this by-product by SsuD and TauD must be necessary for bacterial survival under oxidative stress generated during n-hexadecane degradation.

show abstract

Inhibitory Effect of Taurine on Biofilm Formation During Alkane Degradation in Acinetobacter oleivorans DR1

Cited by 15 publications

References 61 publications

Metabolic Mechanism of Bacillus sp. LM24 under Abamectin Stress

Metabolic Mechanism of Bacillus sp. LM24 under Abamectin Stress

Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments

Protective Role of Bacterial Alkanesulfonate Monooxygenase under Oxidative Stress

Contact Info

Product

Resources

About