Inhibitory Effect of Purple Corn ‘Seakso 1’ Husk and Cob Extracts on Lipid Accumulation in Oleic Acid- Induced Non-Alcoholic Fatty Liver Disease HepG2 Model

This study was investigated to evaluate the in vitro anti-diabetic activity and lipid accumulation inhibitory effect of the domestic walnut (Junglans regia, Gimcheon 1ho cultivar) in high glucose- and oleic acid-induced hepatic HepG2 cells. Eighty percent of ethanolic extract from Gimcheon 1ho (GC) showed higher inhibitory effects against α-amylase and α-glucosidase activities when compared to other ethanolic extracts. GC significantly inhibited the formation of advanced glycation end products (AGEs). The GC increased cell viability against H2O2- and high glucose-induced cell death determined by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. GC reduced the formation of reactive oxygen species (ROS) in H2O2- and high glucose-induced HepG2 cells determined by 2’,7’-dichlorofluorescein diacetate (DCF-DA) assay. GC inhibited lipid accumulation in the oleic acid-induced HepG2 cells. The GC increased AMP-activated protein kinase (AMPK) phosphorylation and decreased the expression of lipid metabolism related proteins such as sterol regulatory element-binding proteins 1 (SREBP-1), fatty acid synthase (FAS), sterol regulatory element-binding protein 2 (SREBP-2) and 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMGCR). The results suggest GC is a potentially functional food material which can improve nonalcoholic fatty liver disease by inhibiting lipid accumulation.

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Major Characteristics of Anthocyanin-Rich Purple Corn Hybrid Variety: ‘Saekso 1’

Park

Ryu³

et al. 2021

Korean J. Breed. Sci.

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A new anthocyanin-rich hybrid variety, 'Saekso 1', is developed which is characterized by yellow grains, and purple husks and cobs. This variety was produced by crossing two inbred lines, 'HA1' (as the seed parent) and 'HA2' (as the pollen parent). It was made in 2008/2009 and evaluated in Hongcheon for two years. After evaluation, the selected variety was named 'Saekso 1' and was approved for a variety registration in 2014. The anthocyanin content of 'Saekso 1' in husk was 10.39±0.09 g/100 g, which was much higher than that of Kangilok (0 mg/100 g). Since regional tests were conducted only in Gangwon province, this variety is recommended only in that region for commercial cultivation. 'Saekso 1' is a health food resource for bioactive materials (Registration No. 4967).

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Inhibitory Effect of Purple Corn ‘Seakso 1’ Husk and Cob Extracts on Lipid Accumulation in Oleic Acid- Induced Non-Alcoholic Fatty Liver Disease HepG2 Model

Cited by 3 publications

References 12 publications

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Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis

Improving effect of domestic walnut (Juglans regia) extract on high glucose- and oleic acid-induced non-alcoholic fatty liver disease in HepG2 cells

Major Characteristics of Anthocyanin-Rich Purple Corn Hybrid Variety: ‘Saekso 1’

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