Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis

CXCL9, IL2RB, and SPP1, potential diagnostic biomarkers in the co-morbidity pattern of atherosclerosis and non-alcoholic steatohepatitis

“…The HUVECs and L02 cells were cultured in RPMI-1640 cell culture medium supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin, respectively, and incubated at 37 °C in humidified 5% CO2. The cells were used from passages 3–8 34 .…”

The additive effect of herbal medicines on lifestyle modification in the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis

“…Regarding the efficacy of the herbal medicines used in the RCTs included in this study, it has been extensively studied for anti-oxidant, anti-inflammatory, hypoglycemic, and lipid-lowering effects of Astragali Radix, Atractylodis Rhizoma Alba, Salviae Miltiorrhizae Radix, Bupleuri Radix, Artemisiae Capillaris Herba, Polygoni Cuspidati Radix, Cassiae Semen, Crataegi Fructus, Poria Sclerotium, Cinnamomi Ramulus, Glycyrrhiza Rhizoma in the treatment of NAFLD (Dai et al, 2021). In addition, several studies demonstrated Coptidis Rhizoma (Li et al, 2024), Polygoni orientalis (Chen et al, 2021), Magnoliae offcinalis (Kuo et al, 2020), and Tegillarca granosa L. (Jiang et al, 2024) improve glucose and lipid metabolism by modulating PI3K-AKT and AMPK signaling pathway, and Coicis Semen (Chiang et al, 2020), Cyperi Rhizoma (Wang et al, 2022), Verbena officinalis L. (Kubica et al, 2020), Trigonella Foenumgraecum L. semen (Yadav and Baquer, 2014), Portulaca oleracea L. (Rahimi et al, 2019), and Rhus Coriaria L. fructus (Alsamri et al, 2021) exhibit anti-oxidant, anti-inflammatory effects by enhancing superoxide dismutase and glutathione activity and inhibiting the production of inflammatory mediators such as nitric oxide, tumor necrosis factor-α, interleukin-1β, interleukin-6, and prostaglandin E2. Since the ingredients and their chemical structure of herbal medicines above have been identified (Abu-Reida et al, 2014;Zhou et al, 2015;Pang et al, 2016;Dong et al, 2017;Yang et al, 2017;Wang et al, 2018;Luo et al, 2019;Wang et al, 2019;Kubica et al, 2020;Liu et al, 2020;Zhu et al, 2020;Chen et al, 2021;Hsueh et al, 2021;Xue et al, 2021;Zhang et al, 2021;Chang et al, 2022;Lu et al, 2022;Singh et al, 2022), it is expected that therapeutics will be developed through analog development based on the previous...…”