Inhibitory effect of procaterol on exercise dynamic lung hyperinflation during the 6-min walk test in stable patients with chronic obstructive pulmonary disease

Satake, Masahiro; Takahashi, Hitomi; Sugawara, Keiyu; Kawagoshi, Atsuoshi; Tamaki, Akira; Homma, Mitsunobu; Morita, Ryou; Sato, Kazuhiro; Sano, Mitsuru; Shioya, Takanobu

doi:10.1055/s-0031-1296162

Cited by 7 publications

(6 citation statements)

References 14 publications

(18 reference statements)

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“…Hence, the present study result showing a relationship between the decrease in IC and dyspnea during the 6MWT is an original finding, and it confirms that IC gradually decreases even during the 6MWT. 24 …”

Section: Discussionmentioning

confidence: 99%

Dynamic hyperinflation and dyspnea during the 6-minute walk test in stable chronic obstructive pulmonary disease patients

Satake¹,

Shioya²,

Uemura³

et al. 2015

COPD

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The purpose of this study was to investigate the relationship between dynamic hyperinflation and dyspnea and to clarify the characteristics of dyspnea during the 6-minute walk test (6MWT) in chronic obstructive pulmonary disease patients. Twenty-three subjects with stable moderate chronic obstructive pulmonary disease (age 73.8±5.8 years, all male) took part in this study. During the 6MWT, ventilatory and gas exchange parameters were measured using a portable respiratory gas analysis system. Dyspnea and oxygen saturation were recorded at the end of every 2 minute period during the test. There was a significant decrease in inspiratory capacity during the 6MWT. This suggested that dynamic hyperinflation had occurred. Dyspnea showed a significant linear increase, and there was a significant negative correlation with inspiratory capacity. It was suggested that one of the reasons that dyspnea developed during the 6MWT was the dynamic hyperinflation. Even though the tidal volume increased little after 2 minutes, dyspnea increased linearly to the end of the 6MWT. These results suggest that the mechanisms generating dyspnea during the 6MWT were the sense of respiratory effort at an early stage and then the mismatch between central motor command output and respiratory system movement.

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Section: Discussionmentioning

confidence: 99%

Dynamic hyperinflation and dyspnea during the 6-minute walk test in stable chronic obstructive pulmonary disease patients

Satake¹,

Shioya²,

Uemura³

et al. 2015

COPD

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“…These range from 20 to 42 m with short-acting β 2 -agonists [60,246], from 6 to 39 m with short-acting anticholinergics [60,247], from 21 to 54 m with long-acting β 2 -agonists [239,248,249] and ∼10 m with long-acting anticholinergics [250].…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement

et al. 2016

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This document reviews 1) the measurement properties of commonly used exercise tests in patients with chronic respiratory diseases and 2) published studies on their utilty and/or evaluation obtained from MEDLINE and Cochrane Library searches between 1990 and March 2015.Exercise tests are reliable and consistently responsive to rehabilitative and pharmacological interventions. Thresholds for clinically important changes in performance are available for several tests. In pulmonary arterial hypertension, the 6-min walk test (6MWT), peak oxygen uptake and ventilation/carbon dioxide output indices appear to be the variables most responsive to vasodilators. While bronchodilators do not always show clinically relevant effects in chronic obstructive pulmonary disease, high-intensity constant work-rate (endurance) tests (CWRET) are considerably more responsive than incremental exercise tests and 6MWTs. High-intensity CWRETs need to be standardised to reduce interindividual variability. Additional physiological information and responsiveness can be obtained from isotime measurements, particularly of inspiratory capacity and dyspnoea. Less evidence is available for the endurance shuttle walk test. Although the incremental shuttle walk test and 6MWT are reliable and less expensive than cardiopulmonary exercise testing, two repetitions are needed at baseline. All exercise tests are safe when recommended precautions are followed, with evidence suggesting that no test is safer than others. @ERSpublications A review of exercise testing to evaluate interventions aimed to improve exercise tolerance in respiratory patients

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“…The overall conclusion is that the 6MWT has a low responsiveness in this setting since most of the studies reported improvement in 6MWD that are well below the MID value for this intervention, ranging from 20 to 42 m with short-acting β 2 -agonist [6, 70, 71], from 6 to 39 metres with short-acting anticholinergics [6, 23], from 21 to 54 metres with long-acting β 2 -agonist [72–74] and around 10 m with long-acting anticholinergics [75]. The lack of responsiveness of the 6MWT could be due to the presence of a ceiling effect with this test.…”

Section: Self-paced Exercise Testsmentioning

confidence: 99%

Responsiveness of Various Exercise-Testing Protocols to Therapeutic Interventions in COPD

et al. 2013

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Exercise intolerance is a key element in the pathophysiology and course of Chronic Obstructive Pulmonary Disease (COPD). As such, evaluating exercise tolerance has become an important part of the management of COPD. A wide variety of exercise-testing protocols is currently available, each protocol having its own strengths and weaknesses relative to their discriminative, methodological, and evaluative characteristics. This paper aims to review the responsiveness of several exercise-testing protocols used to evaluate the efficacy of pharmacological and nonpharmacological interventions to improve exercise tolerance in COPD. This will be done taking into account the minimally important difference, an important concept in the interpretation of the findings about responsiveness of exercise testing protocols. Among the currently available exercise-testing protocols (incremental, constant work rate, or self-paced), constant work rate exercise tests (cycle endurance test and endurance shuttle walking test) emerge as the most responsive ones for detecting and quantifying changes in exercise capacity after an intervention in COPD.

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Inhibitory effect of procaterol on exercise dynamic lung hyperinflation during the 6-min walk test in stable patients with chronic obstructive pulmonary disease

Cited by 7 publications

References 14 publications

Dynamic hyperinflation and dyspnea during the 6-minute walk test in stable chronic obstructive pulmonary disease patients

Dynamic hyperinflation and dyspnea during the 6-minute walk test in stable chronic obstructive pulmonary disease patients

Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement

Responsiveness of Various Exercise-Testing Protocols to Therapeutic Interventions in COPD

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