Inhibitory Effect of Piquerol A on the Growth of Epimastigotes ofTrypanosoma cruzi

Abstract

ments, both in vitro and in vivo, in order to analyse more precisely their mode of action and to try to establish structure-activity relationships.

Trypanocidal Constituents in Plants. 1. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in Guaco, Roots of Aristolochia taliscana.

“…1-4) by a Diaion HP-20 column, activity was observed in less polar fraction 3 eluted with MeOH and fraction 4 eluted with AcOEt. Fractions 3 and 4 were combined and subjected to various kinds of chromatographies to afford four neolignans, eupomatenoid-7 (1), licarin A (2), eupomatenoid-1 (5) and licarin B (6), and two lignans, austrobailignan-7 (3) and fragransin E 1 (4). Although these neolignans were already isolated from Guaco by Enriquez et al, 7) this is the first isolation of lignans 3 and 4 from Guaco.…”

“…In order to seek new chemotherapeutic agents from natural resources, we started a survey of trypanocidal constituents in Mexican plants. Investigation on a trypanocidal constituent in Piqueria trinervia, one of Mexican plants, was already performed by Castro et al 4) As a preliminary screening test, we examined crude extracts of Mexican medicinal plants for trypanocidal activity against epimastigotes of T. cruzi in vitro as previously reported in the case of plants in Guatemala. 5) Among them the MeOH extract of roots of Aristolochia taliscana (Aristolochiaceae) showed trypanocidal activity.…”

Natural products as potential antiparasitic drugs

“…Espintanol (11) has already been discussed above and piquerol A (38) was active about 100 µg/mL [82]. Espintanol, isolated from the bark of Oxandra espinata (Annonaceae) and synthesised [83], is active against Leishmania promastigotes and Trypanosoma epimastigotes.…”

In Vitro and In Vivo Cytotoxicities and Antileishmanial Activities of Thymol and Hemisynthetic Derivatives

“…Because derivatives of p-cymene have leishmanicidal activity (2,8,11) and are considered important basic structures for development of novel antiparasitic drugs (9), in this study the thymol structure was chemically modified and its derivated were evaluated for cytotoxic and antileishmanial activities.…”