Inhibitory effect of panaxytriol on thelipopolysaccharide-induced microglial activation

Walnut-Derived Peptides Alleviate Learning and Memory Impairments in a Mice Model via Inhibition of Microglia Phagocytose Synapses

“…35 Hiramatsu et al showed that panaxytriol suppressed both microglia activation by injecting LPS intracerebrally into mice with LPS-induced brain inflammation. 36 Wang et al showed that Salidroside exerts neuroprotection by inhibiting microglia activation to repair spinal cord injury. 37 In this study, in line with previously mentioned findings, LPS induces synaptic loss through microglial hyperactivation, while TW-7 potentially mitigates memory deficits caused by synaptic loss in mice by restraining the activation of microglia.…”