Inhibitory effect of Ligustrum vulgare leaf extract on the development of neuropathic pain in a streptozotocin-induced rat model of diabetes

Czerwińska, Monika E.; Gąsińska, Emilia; Leśniak, Anna; Krawczyk, Piotr; Kiss, Anna K.; Naruszewicz, Marek; Bujalska‐Zadrożny, Magdalena

doi:10.1016/j.phymed.2018.06.006

Cited by 22 publications

(14 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have reported the therapeutic potential of oleuropein in preventing cognitive decline [34], cancer, pulmonary inflammation [41], and ischemia-reperfusion injury. Moreover, there have been studies showing the usefulness of oleuropein in diabetic, inflammatory, and nociceptive pain [5,7]. However, this is the first experimental study suggesting the analgesic actions of oleuropein in nerve injury-induced pain.…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats

Chen

Zhang

et al. 2021

Korean J Pain

View full text Add to dashboard Cite

Background: The present investigation explored the therapeutic actions of oleuropein along with the possible signaling pathway involved in attenuating neuropathic pain in chronic constriction injury (CCI) and vincristine-induced neuropathic pain in male rats. Methods: Four loose ligatures were placed around the sciatic nerve to induce CCI, and vincristine (50 μg/kg) was injected for 10 days to develop neuropathic pain. The development of cold allodynia, mechanical allodynia, and mechanical hyperalgesia was assessed using different pain-related behavioral tests. The levels of H 2 S, cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), orexin, and nuclear factor erythroid-2-related factor 2 (Nrf2) were measured in the sciatic nerve. Results: Treatment with oleuropein for 14 days led to significant amelioration of behavioral manifestations of neuropathic pain in two pain models. Moreover, oleuropein restored both CCI and vincristine-induced decreases in H 2 S, CSE, CBS, orexin, and Nrf2 levels. Co-administration of suvorexant, an orexin receptor antagonist, significantly counteracted the pain-attenuating actions of oleuropein and Nrf2 levels without modulating H 2 S, CSE and CBS. Conclusions: Oleuropein has therapeutic potential to attenuate the pain manifestations in CCI and vincristine-induced neuropathic pain, possibly by restoring the CSE, CBS, and H 2 S, which may subsequently increase the expression of orexin and Nrf2 to ameliorate behavioral manifestations of pain.

show abstract

Section: Discussionmentioning

confidence: 89%

“…[2][3][4]. Apart from these, the inhibitory actions of oleuropein containing leaf extract of Ligustrum vulgare, in diabetic neuropathic pain, have been documented [5]. Moreover, Olea europaea-derived oleuropein is shown to exhibit antiinflammatory and anti-nociceptive actions [6] and prevent anti-nociceptive tolerance against morphine [7].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats

Chen

Zhang

et al. 2021

Korean J Pain

View full text Add to dashboard Cite

show abstract

“…Oxidative stress has been proven to play a key role in the pathogenesis of diabetes and related complications [ 13 ], and there is evidence that antioxidants, mainly low-molecular-weight natural and synthetic substances, may be useful for the treatment of various pathologies associated with diabetes mellitus [ 14 , 15 ]. Meanwhile, there are many reasons to believe that antioxidant enzymes can be more effective in neutralising reactive oxygen species (ROS) than low-molecular-weight antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Peroxiredoxin 6 Attenuates Alloxan-Induced Type 1 Diabetes Mellitus in Mice and Cytokine-Induced Cytotoxicity in RIN-m5F Beta Cells

Новоселова

Глушкова

Лунин

et al. 2020

Journal of Diabetes Research

View full text Add to dashboard Cite

Type 1 diabetes is associated with the destruction of pancreatic beta cells, which is mediated via an autoimmune mechanism and consequent inflammatory processes. In this article, we describe a beneficial effect of peroxiredoxin 6 (PRDX6) in a type 1 diabetes mouse model. The main idea of this study was based on the well-known data that oxidative stress plays an important role in pathogenesis of diabetes and its associated complications. We hypothesised that PRDX6, which is well known for its various biological functions, including antioxidant activity, may provide an antidiabetic effect. It was shown that PRDX6 prevented hyperglycemia, lowered the mortality rate, restored the plasma cytokine profile, reversed the splenic cell apoptosis, and reduced the β cell destruction in Langerhans islets in mice with a severe form of alloxan-induced diabetes. In addition, PRDX6 protected rat insulinoma RIN-m5F β cells, cultured with TNF-α and IL-1β, against the cytokine-induced cytotoxicity and reduced the apoptotic cell death and production of ROS. Signal transduction studies showed that PRDX6 prevented the activation of NF-κB and c-Jun N-terminal kinase signaling cascades in RIN-m5F β cells cultured with cytokines. In conclusion, there is a prospect for therapeutic application of PRDX6 to delay or even prevent β cell apoptosis in type 1 diabetes.

show abstract

“…В химическом плане наиболее детально изучены листья L. vulgare, которые используются в традиционной медицине. В их составе очень разнообразно представлены секоиридоиды: кемпферол 3-О-глюкозид 7-О-рамнозид; кемпферол 3, 7-О-дирхамнозид; кемпферол-3-О-глюкозид; кверцетин-3-О-глюкозид-7-О-рамнозид; кверцетин-3,7-О-дирхамнозид; лигусталозид А, лигусталозид В, лигстрозид [24]; олеацин (23,48 ± 0,87 мг / г); олеокантал (8,44 ± 0,08 мг / г); олеуропеин (1,50 ± 0,01 мг / г) [15]; лигустрогемиацетали А и В; (2''R) -и (2''S) -10-гидрокси-2 ''метоксиолеуропеины [26]. Также разнообразны флавоноиды.…”

unclassified

“…Фенилпропаноиды представлены эхинакозидом (6,46 ± 0,07 мг / г), вербаскозидом (4,03 ± 0,04 мг / г) и пкумароилглюкаратом [15]. Из фенолов и их производных присутствуют тирозол [22] и гидрокситирозол [19].…”

unclassified

The composition and toxicological characteristics of some chemical compounds Ligustrum vulgare L

Potapova¹,

Дурнова²,

Kuznecova³

et al. 2019

SDTE

View full text Add to dashboard Cite

В статье приводится краткий обзор литературы по химическому составу и характеристике ядовитых компонентов бирючины обыкновенной (Ligustrum vulgare L.). В листьях данного растения обнаружены секоиридоиды, флавоноиды, фенилпропаноиды, фенолы, алкалоиды, урсоловая и олеаноловая кислоты, альдегиды. В коре выявлены дубильные и бета-D-глюкозид сирингин. В плодах найдены секоиридоиды и антоцианы. Такие вещества как эскулетин, олеуропеин, тирозол, сирингин проявляют токсичность по отношению к различным биологическим объектам. Гликозид лигустрин и алкалоид цинхонин являются ядовитыми для человека. Ключевые слова: бирючина обыкновенная, Ligustrum vulgare L., химические соединения, токсичность, отравление.

show abstract

Inhibitory effect of Ligustrum vulgare leaf extract on the development of neuropathic pain in a streptozotocin-induced rat model of diabetes

Cited by 22 publications

References 31 publications

Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats

Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats

Peroxiredoxin 6 Attenuates Alloxan-Induced Type 1 Diabetes Mellitus in Mice and Cytokine-Induced Cytotoxicity in RIN-m5F Beta Cells

The composition and toxicological characteristics of some chemical compounds Ligustrum vulgare L

Contact Info

Product

Resources

About