Inhibitory effect of imperatorin on insulin-like growth factor-1-induced sebum production in human sebocytes cultured in vitro

Im, Myung; Roh, Seok-Seon; Choi, Byoung Wook; Kim, Sue Jeong; Sohn, Kyung-Ah; Lee, Young; Seo, Young‐Joon; Lee, Jeung‐Hoon; Kim, Chang Deok

doi:10.1016/j.lfs.2015.11.027

Cited by 23 publications

(18 citation statements)

References 22 publications

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“…Consistently with the evidence above, inhibition of IIS in primary human sebocytes results in reduced lipogenesis and downregulation of PPARγ and SREBP‐1 . Furthermore, IGF1 stimulates proliferation in rat preputial sebocytes, which aligns with the known stimulatory role of the PI3K/AKT/mTOR pathway in proliferation .…”

Section: Factors Controlling Sebaceous Gland Homeostasissupporting

confidence: 81%

“…184 Primary human sebocytes also contain IGF1R protein. 185 Serum levels of IGF1 correlate with sebum production, and are increased in those with acne. 186,187 Furthermore, polymorphisms within the promoter region of IGF1 are associated with a fourfold increase in the likelihood of developing acne, which may be related to alterations in IGF1 expression.…”

Section: Erbb Family Receptor Signallingmentioning

confidence: 98%

“…SZ95 sebocytes express both IR and IGF1R, while human SGs have been demonstrated to be immunoreactive for IGF1R in the peripheral layer in vivo . Primary human sebocytes also contain IGF1R protein . Serum levels of IGF1 correlate with sebum production, and are increased in those with acne .…”

Section: Factors Controlling Sebaceous Gland Homeostasismentioning

confidence: 99%

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Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

et al. 2019

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Summary Background Sebaceous glands (SGs) are appendages of mammalian skin that produce a mixture of lipids known as sebum. Acne vulgaris is an exceptionally common skin condition, characterized by elevated sebum production, altered sebum composition, and the formation of infundibular cysts, called comedones. Comedo‐associated SGs are atrophic, suggesting that comedo formation involves abnormal differentiation of progenitor cells that generate the SG and infundibulum: the ‘comedo switch’. Understanding the biological processes that govern SG homeostasis promises to highlight potential aetiological mechanisms underlying acne and other SG‐associated skin disorders. Results In this review, we discuss the clinical data, genetic mouse models and in vitro research that have highlighted major hormones, paracrine factors, transcription factors and signalling pathways that control SG homeostasis. These include, but are not limited to androgens, progestogens and oestrogens; retinoids; receptor tyrosine kinases such as ErbB family receptors, fibroblast growth factor receptor 2 and insulin/insulin‐like growth factor 1 receptors; peroxisome proliferator‐activated receptor γ; aryl hydrocarbon receptor; and the Wnt signalling pathway. Where possible, the cellular and molecular mechanisms by which these regulatory factors control SG biology are indicated, along with considerations as to how they might contribute to acne pathogenesis. Conclusions Future research should seek to establish the relative importance, and causative relationships, of altered sebum production, sebum composition, inflammation and abnormal differentiation of sebaceous progenitors to the process of comedo formation in acne. Such an understanding will allow for therapeutic targeting of regulatory factors that control SG homeostasis, with the aim of treating acne.

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Section: Factors Controlling Sebaceous Gland Homeostasissupporting

confidence: 81%

Section: Erbb Family Receptor Signallingmentioning

confidence: 98%

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Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

et al. 2019

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“…SGs in vivo demonstrate immuno‐reactivity for IGF‐1R (Hodak et al ., ; Rudman et al ., ), and treatment of SZ95 and SEB‐1 immortalised sebocytes with IGF‐1 results in increased lipogenesis (Smith et al ., ; Makrantonaki et al ., ; Im et al ., ) and increased expression of inflammatory mediators (Im et al ., ). Similar observations of IGF‐1 mediated stimulation of lipid production have been made using primary human sebocytes, which also express IGF‐1R (Hwang et al ., ).…”

Section: Growth Hormone and Insulin‐like Growth Factormentioning

confidence: 97%

Neuroendocrinology and neurobiology of sebaceous glands

et al. 2020

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The nervous system communicates with peripheral tissues through nerve fibres and the systemic release of hypothalamic and pituitary neurohormones. Communication between the nervous system and the largest human organ, skin, has traditionally received little attention. In particular, the neuro-regulation of sebaceous glands (SGs), a major skin appendage, is rarely considered. Yet, it is clear that the SG is under stringent pituitary control, and forms a fascinating, clinically relevant peripheral target organ in which to study the neuroendocrine and neural regulation of epithelia. Sebum, the major secretory product of the SG, is composed of a complex mixture of lipids resulting from the holocrine secretion of specialised epithelial cells (sebocytes). It is indicative of a role of the neuroendocrine system in SG function that excess circulating levels of growth hormone, thyroxine or prolactin result in increased sebum production (seborrhoea). Conversely, growth hormone deficiency, hypothyroidism, and adrenal insufficiency result in reduced sebum production and dry skin. Furthermore, the androgen sensitivity of SGs appears to be under neuroendocrine control, as hypophysectomy (removal of the pituitary) renders SGs largely insensitive to stimulation by testosterone, which is crucial for maintaining SG homeostasis. However, several neurohormones, such as adrenocorticotropic hormone and α-melanocyte-stimulating hormone, can stimulate sebum production independently of either the testes or the adrenal glands, further underscoring the importance of neuroendocrine control in SG biology. Moreover, sebocytes synthesise several neurohormones and express their receptors, suggestive of the presence of neuro-autocrine mechanisms of sebocyte modulation. Aside from the neuroendocrine system, it is conceivable that secretion of neuropeptides and neurotransmitters from cutaneous nerve endings may also act on sebocytes or their progenitors, given that the skin is richly innervated. However, to date, the neural controls of SG development and function remain poorly investigated and incompletely understood. Botulinum toxin-mediated or facial paresis-associated reduction of human sebum secretion suggests that cutaneous nerve-derived substances modulate lipid and inflammatory cytokine synthesis by sebocytes, possibly implicating the nervous system in acne pathogenesis. Additionally, evidence suggests that cutaneous denervation in mice alters the expression of key regulators of SG homeostasis. In this review, we examine the current evidence regarding neuroendocrine and neurobiological regulation of human SG function in physiology and pathology. We further call attention to this line of research as an instructive model for probing and therapeutically manipulating the mechanistic links between the nervous system and mammalian skin.

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“…15 Apesar da IGF-1 e da hormona de crescimento promoverem a inflamação e a comedogénese, são os fatores de transcrição da célula da glândula sebácea, os responsáveis pela regulação fina desse estímulo, sendo estes influenciados por fatores da dieta do indivíduo. 16,17 ( Fig. 2) O FoxO1 nuclear é um fator de transcrição metabóli-co que, além de atuar como um co-supressor do recetor de androgénio, inibe também o receptor Xa hepático a (LXRa), a proteína 1c de ligação ao elemento de resposta aos esteróides (SREBP-1c) e o receptor γ ativador da proliferação peroxisomal (PPARγ), importantes fatores de transcrição na lipogénese sebácea .…”

Section: Métodosunclassified

Influência do Índice de Massa Corporal e da Dieta na Fisiopatologia da Acne Vulgaris

Silva

Velho

2018

SPDV

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RESUMO -Acne vulgar é uma patologia multifatorial que afeta principalmente adolescentes e jovens adultos e que se pode manifestar como lesões inflamatórias ou não inflamatórias. Esta doença acarreta morbilidade significativa, tanto física como psicológica. Está cientificamente comprovada a importância de diversos fatores, tanto genéticos como ambientais, na sua patogénese, tendo sido descritas nomeadamente associações com a dieta ocidental, índice de massa corporal excessivo e a resistência à insulina. Neste artigo é efetuada revisão da atual literatura relativa à acne vulgar, com enfoque na fisiopatologia e influência destes fatores na sua desregulação. O melhor conhecimento da fisiopatologia da acne e a avaliação crítica do papel da dieta, bem como da obesidade e da desregulação do sistema endócrino, podem contribuir para uma abordagem mais científica dos fatores exógenos que contribuem no início e agravamento desta interessante e frequente patologia. PALAVRAS-CHAVE -Acne Vulgaris/etiologia; Acne Vulgaris/fisiopatologia; Dieta; Índice de Massa Corporal; Obesidade. Influence of Body Mass Index and Diet on the Pathophysiology of Acne Vulgaris ABSTRACT -Acne vulgaris is a multifactorial disease that mainly affects adolescents and young adults and can present either with inflammatory or non-inflammatory lesions. This disease is responsible for significant morbidity, both physical and psychological. The importance of both genetic and environmental factors in its pathogenesis has been scientifically proven, and associations with the western diet, excessive body mass index and insulin resistance have been described. In this article we review the current literature on acne vulgaris, focusing on the pathophysiology and influence of these factors on its disregulation. A better knowledge of the physiopathology of acne and a critical evaluation of the influence of diet, body mass index and disruption of the endocrine system will allow a more scientific intervention on exogenous factors that contribute to the initiation and worsening of this interesting and frequent pathology. KEYWORDS - INTRODUÇÃOA acne vulgar é uma das patologias dermatológicas mais comuns na população geral, afetando 85% dos jovens adultos entre os 12 e os 25 anos.1 O género masculino é o mais afetado, particularmente nas formas mais severas da doença.2 A acne persiste em 64% dos indivíduos com 20-30 anos e 43% dos indivíduos com 30-40 anos.3 Afeta a unidade pilossebácea através de processos de hiperqueratose infundibular, hipersecreção sebácea, colonização microbiana (Propionibacterium acnes e Malassezia furfur) e mecanismos imunológicos. Manifesta-se com lesões inflamatórias (pápulas, pústulas ou nódulos) ou não inflamatórias (comedões abertos ou fechados) com localização mais comum na face, tronco e dorso, podendo ser classificada como ligeira, moderada e severa.4-6 A maior parte dos indivíduos desenvolve formas leves da doença, sendo que um pequeno número de

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Inhibitory effect of imperatorin on insulin-like growth factor-1-induced sebum production in human sebocytes cultured in vitro

Cited by 23 publications

References 22 publications

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

Neuroendocrinology and neurobiology of sebaceous glands

Influência do Índice de Massa Corporal e da Dieta na Fisiopatologia da Acne Vulgaris

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