Inhibitory Effect of Grapefruit Juice on the Genotoxic Damage Induced by Ifosfamide in Mouse

Álvarez-González, Isela; Madrigal-Bujaidar, Eduardo; Sánchez-García, Vanesa Y.

doi:10.1007/s11130-010-0193-1

Cited by 26 publications

(11 citation statements)

References 28 publications

(41 reference statements)

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“…Miyata et al [27], stated that rats allowed free access to grapefruit juice for 5 days prior to AFB1 administration resulted in clearly reduced DNA damage in liver. Alvarez-Gonzá lez et al (16), reported that the consumption of grapefruit juice has been associated with various activities potentially beneficial for human health, including protection against the DNA damage produced by various compounds. They found that grapefruit juice inhibited the rate of micronucleated polychromatic erythrocytes and sister chromatid exchanges induced by the antineoplastic alkylating agent ifosfamide.…”

Section: Discussionmentioning

confidence: 99%

“…Naringin, abioflovnoid predominant in grape fruit and other citrus fruits, has been found to scavenge free radicals and reduce radiation induced damage such as reduction of aberrant cells and chromosomal aberrations [15]. Consumption of grapefruit juice was found to be beneficial for human health, including protection against the DNA damage [16]. The present work aims to study the possible protective effect of grapefruit juice on rytmonorm-induced cytogenetic and testicular alterations in albino rats.…”

Section: Introductionmentioning

confidence: 97%

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Rytmonorm-Induced Cytogenetic and Testicular Damage in Albino Rats: The Protective Effect of Grapefruit Juice

Sakr¹,

Zoail²,

El-Shafey³

2013

AJBR

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The present work studied the cytogenetic and testicular damage induced by the antiarrhythmic drug rytmonorm (RT) and the protective role of grapefruit juice in albino rats. Treating rats with RT (13.5mg/Kg bodyweight) for five weeks caused a significant increase in the percentage of chromosomal aberrations either structural or numerical and decrease the mitotic index. Using comet assays, RT caused DNA fragmentation in the lymphocytes. Testis of RT treated rats showed many histopathological and morphometric alterations. In addition, the number of sperm head abnormalities was increased. Treating animals with RT and grapefruit juice (27ml/Kg bodyweight) led to an improvement in chromosomal aberrations, mitotic index, DNA damage, and testicular alterations caused by RT. In conclusion, the results of this study indicated that grapefruit juice showed a protective effect on cytotoxicty and testicular alterations induced by RT in albino rats and this is may be due to its potent antioxidant effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Rytmonorm-Induced Cytogenetic and Testicular Damage in Albino Rats: The Protective Effect of Grapefruit Juice

Sakr¹,

Zoail²,

El-Shafey³

2013

AJBR

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“…The comet assay revealed that piquiá pulp treatments decreased the DNA damage induced by DXR, and the greatest reductions were found in the liver and heart. The antigenotoxic potentials of fruits were also evaluated in other studies [23,24]. Although the exact mechanism of the inhibition of DXR-induced genotoxicity by piquiá pulp has not been thoroughly elucidated, the antioxidant compounds may explain the protective effects of piquiá pulp verified in this study.…”

Section: Discussionmentioning

confidence: 79%

Antigenotoxic Effects of Piquiá (Caryocar villosum) in Multiple Rat Organs

Almeida

Darin

Hernandes

et al. 2012

Plant Foods Hum Nutr

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This study investigated the in vivo genotoxicity of piquiá pulp (Caryocar villosum) and its potential antigenotoxicity on doxorubicin (DXR)-induced DNA damage by comet assay and micronucleus test. In addition, the phytochemicals present in piquiá pulp were determined. Piquiá fruit pulp (75, 150 or 300 mg/kg b.w.) was administered by gavage to Wistar rats for 14 days, and the animals received an injection of saline or DXR (15 mg/kg b.w., i.p.) 24 h before they were euthanized. The phytochemical analysis revealed the presence of carotenoids; phenolic compounds, including flavonoids; tannins and α-tocopherol in piquiá pulp. No statistically significant differences were observed in the evaluated parameters, demonstrating the absence of cytotoxic and genotoxic effects of piquiá pulp at all tested doses. In liver, kidney, cardiac and bone marrow cells, piquiá significantly reduced the DNA damage induced by DXR. Our results showed that the lowest piquiá dose caused the largest decrease in DNA damage and the highest dose caused the smallest decrease, demonstrating an inverse dose-response of piquiá pulp. Furthermore, we observed a difference in the potential antigenotoxic effects in several tissues. In conclusion, our results demonstrated that piquiá pulp was not genotoxic and inhibited the genotoxicity induced by DXR, but some of the protective effects that were observed depended on the doses and experimental conditions. Therefore, further investigations are needed to clarify how piquiá pulp positively affects human health.

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“…Grapefruit juice is commonly consumed in many countries for its nutritive value, as well as antigenotoxic and antioxidant effects [39]. [40] indicated that two bioactive compounds were isolated from grapefruit juice and grapefruit peel oil.…”

Section: Discussionmentioning

confidence: 99%

Effect of Grapefruit Juice on Aluminum-Induced Hepatotoxicity in Albino Rats: Histological, Ultrastructural and Histochemical Assessment

Al-Amoudi¹

2017

ABB

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The present work studied the effect of grapefruit juice (Citrus) on the hepatotoxicity of AlCl 3 . Four groups of adult male albino rats were used. Group I contained 10 rats and remained as a control group; Group II: 10 rats were included and orally administered with grapefruit juice at a dose level of 27 ml/kg of body weight per day for 6 weeks; Group III: 10 rats were included and AlCl 3 was administered orally at a dose level of 100 mg/kg of body weight per day for 6 weeks; Group IV: animals of this group (10 rats) were given a combination of AlCl 3 and grapefruit juice per day for 6 weeks. At the end of the sixth week, the liver was processed for histological and ultrastructure studies. In addition, ALT and AST were determined in blood sera. The results showed that AlCl 3 induced several histological alterations in the liver, including congestion of blood vessels, leucocytic infiltration, cytoplasmic vacuolation of hepatocytes and fatty infiltrations. Ultrastructural changes include the degeneration of mitochondria, RER swelling and pyknosis of the nuclei with an increase in fat droplets and lysosomes. The biochemical results showed an increase in ALT and AST activities in the AlCl 3 group. However, the group of rats treated with AlCl 3 and grapefruit juice improved the histological and ultrastructural changes, while the levels of ALT and AST were reduced. It was concluded in the results that grapefruit juice has a protective effect against hepatotoxicity of AlCl 3 that can be attributed to the antioxidant properties of its components.

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Inhibitory Effect of Grapefruit Juice on the Genotoxic Damage Induced by Ifosfamide in Mouse

Cited by 26 publications

References 28 publications

Rytmonorm-Induced Cytogenetic and Testicular Damage in Albino Rats: The Protective Effect of Grapefruit Juice

Rytmonorm-Induced Cytogenetic and Testicular Damage in Albino Rats: The Protective Effect of Grapefruit Juice

Antigenotoxic Effects of Piquiá (Caryocar villosum) in Multiple Rat Organs

Effect of Grapefruit Juice on Aluminum-Induced Hepatotoxicity in Albino Rats: Histological, Ultrastructural and Histochemical Assessment

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