Inhibitory Effect of DA-9201, an Extract of Oryza sativa L., on Airway Inflammation and Bronchial Hyperresponsiveness in Mouse Asthma Model

Lee, Seungho; Sohn, Yong Sung; Kang, Kyung Koo; Kwon, Jong Won; Yoo, Moohi

doi:10.1248/bpb.29.1148

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…Also noteworthy is the fact that baseline IL-5 levels were rather high, a consistent finding in our experience with this model. Although this did not prevent HDM from inducing an increase, it is worth analyzing further the causes of such lung IL-5 expression in nonsensitive mice, a finding also observed by others [30, 31]. It appears likely that the anti-eosinophilic potential of PGE 2 we observed in vivo will be mediated, at least in part, by IL-5 [32].…”

Section: Discussionsupporting

confidence: 63%

Subcutaneous Prostaglandin E2 Restrains Airway Mast Cell Activity in vivo and Reduces Lung Eosinophilia and Th2 Cytokine Overproduction in House Dust Mite-Sensitive Mice

Herrerias¹,

Torres²,

Serra³

et al. 2009

Int Arch Allergy Immunol

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Background: Prostaglandin (PG) E₂ is thought to exert protective effects in the lungs. Accordingly, aerosolized PGE₂ prevents the experimentally induced airway response to allergen challenge in asthmatics. In vitro evidence indicating that functional PGE₂ receptors (EP) are expressed on human mast cells and that PGE₂ can alter cytokine production suggests that these phenomena may be involved in its beneficial effect in asthma. However, in vivo evidence is scarce. Methods: We assessed the effects of exogenous PGE₂ and of the EP1/EP3 agonist sulprostone on the murine airway response to house dust mite (HDM) allergens, a model that accurately reproduces the spontaneous exposure of allergic asthma patients to aeroallergens. We also analyzed the in vivo impact of PGE₂ on production in the murine airway of mast cell protease (mMCP)-1, a specific marker of lung mast cell activity, and on local production of cytokines. Results: Exogenous PGE₂, but not sulprostone, reduced eosinophilic infiltration in HDM-sensitized mice by half and led to a strong reduction in airway Th₂ cytokine expression. These anti- inflammatory effects were accompanied in vivo by a substantial reduction in HDM-induced upregulation of airway mMCP-1. Neither PGE₂ nor sulprostone had any effect on airway hyperresponsiveness to methacholine. Conclusions: Our results indicate that the anti-inflammatory effect of PGE₂ can be reproduced in vivo in HDM-sensitized mice and suggest that this protective effect is dependent in vivo on inhibition of the allergen-triggered proinflammatory activity of bronchial mast cells. Finally, the effect of PGE₂ is linked to reduced upregulation of airway Th₂ cytokines.

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Section: Discussionsupporting

confidence: 63%

Subcutaneous Prostaglandin E2 Restrains Airway Mast Cell Activity in vivo and Reduces Lung Eosinophilia and Th2 Cytokine Overproduction in House Dust Mite-Sensitive Mice

Herrerias¹,

Torres²,

Serra³

et al. 2009

Int Arch Allergy Immunol

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“…Rice has been used in folk medicine and the cosmetics industry in Korea, China, and Japan for many years [ 25 ]. It has been used for the treatment of various allergic disorders, such as dermatitis and bronchitis, as well as skin aging and other conditions [ 26 – 28 ]. Because of the demonstrated biological efficacy of R and normal rice (NR) in various skin disorders, we hypothesized that resveratrol-enriched rice (RR) may exhibit synergistic or additive effects.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades

Subedi

Lee

Wahedi

et al. 2017

Oxidative Medicine and Cellular Longevity

133

116

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The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-κB-TNF-α/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging. There is an urgent requirement for a treatment that not only controls these pathways to prevent skin aging but also avoids the adverse effects often encountered when applying bioactive compounds in concentrated doses. In this study, we investigated the efficacy of genetically modified normal edible rice (NR) that produces the antiaging compound resveratrol (R) as a treatment for skin aging. This resveratrol-enriched rice (RR) overcomes the drawbacks of R and enhances its antiaging potential by controlling the abovementioned three major pathways of skin aging. RR does not exhibit the toxicity of R alone and promisingly downregulates the pathways underlying UVB-ROS-induced skin aging. These findings advocate the use of RR as a nutraceutical for antiaging purposes.

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“…The pigment from black rice contains two major anthocyanins: cyanidin-3-glucoside and peonidin-3-glucoside (Hu et al, 2003;Abdel-Aal et al, 2006). Anthocyanins are naturally occurring phenolic compounds that provide the color of many fruits (especially berries) and vegetables and they have several valuable effects (Murota et al, 2002;Kerckhoffs et al, 2002;Lee et al, 2006;Wu et al, 2006). Anthocyanins can decrease the risk of coronary heart diseases, inflammatory process, and atherosclerosis through their antioxidant, anti-platelet and anti-inflammatory activities (Hu et al, 2003;Xia et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of a black rice extract (Oryza sativa L. indica) on cholesterol levels and plasma lipid parameters in Wistar Kyoto rats

Zawistowski

Kopeć

Kitts

2009

Journal of Functional Foods

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RatsOryzanol Cholesterol A B S T R A C TThis study was designed to evaluate the efficacy of an anthocyanin pigmented rice (e.g.black rice) to mitigate the onset of hypercholesterolemia in rats-fed atherogenic diets.Male Wistar (n = 10/group) rats were fed with atherogenic diets containing 0.5% cholesterol in the presence and in the absence of bile salt (e.g. 0.05% cholic acid) along with a standardized black rice extract (BRE) (e.g. 3%, w/w). All animals were individually housed in stainless steel cages and fed with the experimental diets during a 12-h period for 10 weeks. Body weights of rats were measured every week of the experiment. After 10 weeks fed on experimental diets, rats were sacrificed and plasma total cholesterol, HDL and LDL cholesterol and triacylglycerols were measured immediately. The total cholesterol (TC) content in the liver, heart and aorta, and the concentration of triacylglycerol (TAG) were measured after lipid extraction using Folch method. Rats fed with 0.5% cholesterol containing diets which also included bile salt exhibited a considerably more severe hypercholesterolemia than counterparts fed diets containing only 0.5% cholesterol. The inclusion of the BRE in diets significantly (p < 0.05) decreased the level of TC, LDL-TC and TAG in plasma of rats-fed control diets that either contained or were absent in bile salt (p < 0.05). There were no differences in HDL-level. Liver crude lipids and total cholesterol levels were also significantly (p < 0.05) decreased in experimental groups relative to the control group in both experiments. Thus, supplementation of atherogenic experimental diets with BRE effectively decreased lipid levels in hypercholesterolemic rats. In lieu of the mixture of bioactive components present in BRE, it is possible that more than one mechanism underlying this reduction in lipids is involved.

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Inhibitory Effect of DA-9201, an Extract of Oryza sativa L., on Airway Inflammation and Bronchial Hyperresponsiveness in Mouse Asthma Model

Cited by 7 publications

References 14 publications

Subcutaneous Prostaglandin E<sub>2</sub> Restrains Airway Mast Cell Activity in vivo and Reduces Lung Eosinophilia and Th<sub>2</sub> Cytokine Overproduction in House Dust Mite-Sensitive Mice

Subcutaneous Prostaglandin E<sub>2</sub> Restrains Airway Mast Cell Activity in vivo and Reduces Lung Eosinophilia and Th<sub>2</sub> Cytokine Overproduction in House Dust Mite-Sensitive Mice

Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades

Effects of a black rice extract (Oryza sativa L. indica) on cholesterol levels and plasma lipid parameters in Wistar Kyoto rats

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