Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades

Abstract

The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-κB-TNF-α/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging. There is an urgent requirement for a treatment that not only controls these pathways to prevent skin aging but also avoids the adverse effects often encountered when applying bioactive compounds in concentrated doses. In this study, we investigated the efficacy of genetically modified normal edible rice (NR) that produces the antiaging compound resveratrol (R) as a treatment for skin aging. This resveratrol-enriched rice (RR) overcomes the drawbacks of R and enhances its antiaging potential by controlling the abovementioned three major pathways of skin aging. RR does not exhibit the toxicity of R alone and promisingly downregulates the pathways underlying UVB-ROS-induced skin aging. These findings advocate the use of RR as a nutraceutical for antiaging purposes.

Effect of resveratrol and pterostilbene on aging and longevity

“…In aged female mice, resveratrol administration attenuated inflammation in visceral adipose tissue and in the brain and decreased peripheral inflammation and stroke‐induced brain injury . Resveratrol‐enriched rice has been shown to retard inflamm‐aging in dermal fibroblasts through controlling matrix metalloproteinase‐1 (MMP‐1)‐mediated ultraviolet B (UVB)‐induced skin aging, apoptosis‐induced skin aging, and inflammation in dermal . In clinical studies, there is less certain evidence to suggest protective effect of resveratrol on inflamm‐aging.…”

Effects of age on the green autofluorescence of the skin and fingernails of healthy persons

“…Therefore, two factors may determine the AF intensity: The first is the levels of oxidative stress in the blood, and the second is the keratin 1 levels in the epidermis. It has been reported that chronic UV radiationa key cause of skin aging (12)on the skin can induce a decrease in the keratin 1 level of the skin (14). In contrast, it is established that there is an age-dependent increase in oxidative stress in human body (15).…”

Antiaging Cosmeceuticals in Korea and Open Innovation in the Era of the 4th Industrial Revolution: From Research to Business

“…Histologically, wrinkled skin is characterized by the accumulation of altered elastic fibers and degradation or degeneration of collagen bundles in the dermis [7,8]. Ultraviolet-B (UVB) induced reactive oxygen species (ROS) production activates mitogen-activated protein kinase (MAPK) signaling and the transcription factors activator protein-1 (AP-1) and nuclear factor-κB (NF-κB), which further induce inflammaging and apoptosis in cells and cause skin aging [9]. As the skin ages, it becomes drier, and the number of fine wrinkles, which become gradually deeper as time goes by, increases.…”