Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease

Ahmed, Touqeer; Gilani, Anwarul Hassan

doi:10.1016/j.pbb.2008.09.010

Cited by 261 publications

(146 citation statements)

References 49 publications

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“…In vitro experiments also confirmed that curcumin inhibits AChE activity and has an IC 50 value of 67 µmol/L [54]. The strongest AChE inhibition was found using bisdemethoxycurcumin; a single dose of 30 µmol/L of bismethoxy curcumin, dimethoxy curcumin, or curcumin inhibits 85, 55, or 31% of AChE activity respectively [55].…”

Section: Discussionmentioning

confidence: 72%

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain

et al. 2018

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Nicotine is a stimulatory component in tobacco that activates the central nervous system reward pathway and causes nicotine dependence. We found that the anti-inflammatory agent, curcuminoid, prevents nicotine dependence and relapse, as assessed by the conditioned placed preference test. Curcuminoid (1, 3.2, and 10 mg·kg^–1, oral) dose-dependently inhibited nicotine dependence and enhanced nicotine extinction when administrated 30 min prior to nicotine administration (0.5 mg·kg^–1, i.p.) for 7 days. In addition, curcuminoid significantly suppressed the priming effects of nicotine and inhibited acetylcholinesterase (AChE) activity. Taken together, curcuminoid ameliorates nicotine dependence and relapse, in part via the inhibition of the AChE activity in the brain.

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Section: Discussionmentioning

confidence: 72%

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain

et al. 2018

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“…43 It was also observed that CRM played a role in the inhibition of AChE production. 44 As revealed in Figure 5C, the AChE activity of the Aβ + WGA-CRM-CL/LIP group was almost equivalent to that of the control group. This showed that after the insult with Aβ, WGA-CRM-CL/LIP could be efficacious in suppressing the synthesis of AChE and reduce the decomposition of acetylcholine for better neurotransmission.…”

mentioning

confidence: 70%

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

Kuo¹,

Lin²,

Li³

et al. 2017

IJN

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Curcumin (CRM) and nerve growth factor (NGF) were entrapped in liposomes (LIP) with surface wheat germ agglutinin (WGA) to downregulate the phosphorylation of kinases in Alzheimer’s disease (AD) therapy. Cardiolipin (CL)-conjugated LIP carrying CRM (CRM-CL/LIP) and also carrying NGF (NGF-CL/LIP) were used with AD models of SK-N-MC cells and Wistar rats after an insult with β-amyloid peptide (Aβ). We found that CRM-CL/LIP inhibited the expression of phosphorylated p38 (p-p38), phosphorylated c-Jun N-terminal kinase (p-JNK), and p-tau protein at serine 202 and prevented neurodegeneration of SK-N-MC cells. In addition, NGF-CL/LIP could enhance the quantities of p-neurotrophic tyrosine kinase receptor type 1 and p-extracellular signal-regulated kinase 5 for neuronal rescue. Moreover, WGA-grafted CRM-CL/LIP and WGA-grafted NGF-CL/LIP significantly improved the permeation of CRM and NGF across the blood–brain barrier, reduced Aβ plaque deposition and the malondialdehyde level, and increased the percentage of normal neurons and cholinergic activity in the hippocampus of AD rats. Based on the marker expressions and in vivo evidence, current LIP carriers can be promising drug delivery systems to protect nervous tissue against Aβ-induced apoptosis in the brain during the clinical management of AD.

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“…Flavonoids also have known antioxidant abilities, effectively protecting neurons against neurotoxins, suppressing neuroinflammation, and enhancing neuronal function (Vafeiadou et al, 2007;Ward et al, 2002), stimulating neuronal regeneration and revascularization (Harvsteen, 2002;Singh et al, 2008). Flavonoids have also been reported to act as an AChE inhibitor (Ahmed & Gilani, 2009).…”

Section: Research Articlementioning

confidence: 99%

Combretum mucronatumandCapparis thonningiiprevent scopolamine-induced memory deficit in mice

Ishola

Adeyemi

Agbaje

et al. 2012

Pharmaceutical Biology

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Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease

Cited by 261 publications

References 49 publications

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

Combretum mucronatumandCapparis thonningiiprevent scopolamine-induced memory deficit in mice

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Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease

Cited by 261 publications

References 49 publications

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain

Inhibition of Nicotine Dependence by Curcuminoid Is Associated with Reduced Acetylcholinesterase Activity in the Mouse Brain

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer&rsquo;s disease treatment

Combretum mucronatumandCapparis thonningiiprevent scopolamine-induced memory deficit in mice

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Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment