Inhibitory effect of benzethonium and zinc chloride mouthrinses on human dental plaque and gingivitis

Compton, F H; Beagrie, G. S.

doi:10.1111/j.1600-051x.1975.tb01724.x

Cited by 41 publications

(16 citation statements)

References 29 publications

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“…beagles did not affect its efficacy with respect to plaque reduction. The results reported in this paper confirm those of Compton and Beagrie (1975) who showed that 0.075 percent BTC was effective in reducing dental plaque and gingivitis in humans.…”

Section: Resultssupporting

confidence: 90%

Long term anti‐plaque gingivitis and calculus effects of benzethonium chloride in beagle dogs

Gaffar

Marcussen

Solls‐Gaffar

et al. 1980

J of Periodontal Research

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Beagle dogs were treated with 0.1 % aqueous solution of benzethonium chloride or with water for 27 weeks and for an additional three weeks to ascertain whether or not the plaque inhibiting effect of BTC was altered because of initial long‐term treatment. The results of this study show 0.1 % BTC significantly reduced plaque and gingivitis in beagles for 27 weeks, This plaque inhibitory effect of BTC was maintained in the subsequent three weeks, suggesting that its initial 27 weeks usage did not result in a change of “oral flora” that affected its efficacy.

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Section: Resultssupporting

confidence: 90%

Long term anti‐plaque gingivitis and calculus effects of benzethonium chloride in beagle dogs

Gaffar

Marcussen

Solls‐Gaffar

et al. 1980

J of Periodontal Research

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“…min. The strips were then soaked in freshly In contrast, Compton and Beagrie (1975) collected, wax-stimulated, human whole found no effect when a mouthwash contain-saliva (WSS) for 20 min and then placed on ing 0.22% zinc chloride solution (16.4 mM hooks of nichrome wire inserted into the zinc) was used for 10 days. However, since it underside of rubber bungs.…”

mentioning

confidence: 99%

Inhibition of plaque growth by zinc salts

Harrap

Saxton

Best

1983

J of Periodontal Research

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Certain metal salts inhibit the growth of dental plaque. The effect of zinc salts was investigated because of contradictory reports in the literature. Using cultures of human plaque, artificial dental plaques were grown in vitro on aluminium strips. The effect of various zinc salts was examined by treating the strips intermittently with solutions of the salts during the period of growth. The action of mouthwashes containing zinc salts in vivo on plaque growth was determined in human volunteers.All the water-soluble zinc salts that were tested gave a similar concentration-dependent inhibition of plaque growth in vitro. The effectiveness of the treatment was reduced by increasing the time allowed for growth after the final application of zinc.Solutions of zinc (17-19 mM) as the citrate or phenolsulphonate salt, gave about 30% reduction in the extension of plaque along the gingival margin in vivo over 16 hours. Subjects with high rates of plaque growth with the placebo mouthwash were most affected by zinc salts. Increasing the zinc concentration to 30 mM did not further increase the activity. Previous reports of low activity of zinc against plaque growth in vivo are explained by too low a concentration of zinc or too low a frequency of application. The results confirm that zinc salts, including zinc citrate, inhibit the growth of plaque in vivo and in vitro. Fishman et al. (1973) used a mixture of Address:

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“…In addition, elementary students are provided instant hand sanitizers containing QACs to decrease the spread of illness and reduce rates of absenteeism [12]. QACs are being increasingly incorporated into contemporary products that are utilized orally, such as mouth wash, applied to the skin or eyes or administered as a nasal spray [13–20]. …”

Section: Introductionmentioning

confidence: 99%

Exposure to common quaternary ammonium disinfectants decreases fertility in mice

Melin

Potineni

Hunt

et al. 2014

Reproductive Toxicology

101

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Quaternary ammonium compounds (QACs) are antimicrobial disinfectants commonly used in commercial and household settings. Extensive use of QACs results in ubiquitous human exposure, yet reproductive toxicity has not been evaluated. Decreased reproductive performance in laboratory mice coincided with the introduction of a disinfectant containing both alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC). QACs were detected in caging material over a period of several months following cessation of disinfectant use. Breeding pairs exposed for six months to a QAC disinfectant exhibited decreases in fertility and fecundity: increased time to first litter, longer pregnancy intervals, fewer pups per litter and fewer pregnancies. Significant morbidity in near term dams was also observed. In summary, exposure to a common QAC disinfectant mixture significantly impaired reproductive health in mice. This study illustrates the importance of assessing mixture toxicity of commonly used products whose components have only been evaluated individually.

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Inhibitory effect of benzethonium and zinc chloride mouthrinses on human dental plaque and gingivitis

Cited by 41 publications

References 29 publications

Long term anti‐plaque gingivitis and calculus effects of benzethonium chloride in beagle dogs

Long term anti‐plaque gingivitis and calculus effects of benzethonium chloride in beagle dogs

Inhibition of plaque growth by zinc salts

Exposure to common quaternary ammonium disinfectants decreases fertility in mice

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