Inhibitory effect of bassianolide, a cyclodepsipeptide, on drug-induced contractions of isolated smooth muscle preparations.

Nakajyo, Shinjiro; Shimizu, Kazumasa; Kometani, Atsuko; Kato, K.; Kamizaki, Junji; Isogai, Akira; Urakawa, Norimoto

doi:10.1254/jjp.32.55

Cited by 11 publications

(6 citation statements)

References 22 publications

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“…Nakajyo et al (3) have reported that BASS inhibits the isotonic contractions induced by cholinergic drugs, histamine, 5-hydroxytryptamine and pro staglandin E2; but it slightly inhibits the contraction induced by barium (Ba) or high concentration of potassium (high K) in the ileal longitudinal muscle preparation of guinea-pig. Moreover, BASS inhibited the contractions induced by adrenergic and cholinergic drugs and histamine, though it hardly influenced the contraction by Ba or high K in guinea-pig vas deferens (3). On the other hand, Nakajyo et al (4) have shown that BASS inhibited the contraction by high K, Ba or tetraethylammonium as well as adrenergic drugs in guinea-pig aorta.…”

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confidence: 99%

On the inhibitory mechanism of bassianolide, a cyclodepsipeptide, in acetylcholine-induced contraction in guinea-pig taenia coli.

et al. 1983

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confidence: 99%

On the inhibitory mechanism of bassianolide, a cyclodepsipeptide, in acetylcholine-induced contraction in guinea-pig taenia coli.

et al. 1983

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“…Carbachol was more potent than acetylcholine in inducing contraction in guinea pig taenia caeci (present experiment) and rat airway smooth muscles (8). In contrast, acetylcholine was stronger than carbachol in inducing contraction in guinea pig ileum (9) and bovine coronary artery (10). The difference may be…”

Section: Different Effects Of Acetylcholine and Carbacholmentioning

confidence: 56%

Carbachol but Not Acetylcholine Inhibits Contraction by the Protein Kinase C-Dependent and -Independent Pathways in the Smooth Muscle of Guinea Pig Taenia Caeci

Mitsui-Saito

Karaki

1996

Japanese Journal of Pharmacology

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ABSTRACT-In the intestinal smooth muscle of guinea pig taenia caeci, acetylcholine and carbachol induced a transient contraction followed by a sustained contraction. The magnitudes of the transient and sustained contractions were similar when muscle was stimulated with acetylcholine (0.1 uM -1 mM) or a lower concentration (0.1 rM) of carbachol. However, higher concentrations of carbachol (1-100 pM) induced significantly smaller sustained contraction than the transient contraction. In the 45 mM KCl-stimulated strips, addition of 100 pM carbachol induced a transient increase followed by a sustained decrease in the contractile tension. In contrast, acetylcholine (0.1 pM -1 mM) showed only weak inhibitory effects on the high K+-induced contraction either in the absence or presence of a cholinesterase inhibitor, 0.5 pM diisopropylfluorophosphate.The same concentration of diisopropylfluorophosphate shifted the concentration-response curve for acetylcholine to lower concentrations. In the muscles pretreated with 3 pM phorbol 12-myristate 13-acetate for 24 hr to desensitize protein kinase C, sustained contractions induced by higher concentrations of carbachol (1-100 pM) were significantly greater than those in the strips without the treatment with phorbol ester. However, the transient contraction and the contraction induced by a lower concentration (0.1 I-pM) of carbachol were not changed by the treatment with phorbol ester. Pretreatment with phorbol ester attenuated the inhibitory effect of carbachol on the high K+-induced contraction. These results suggest that the inhibitory effects of carbachol is composed of two phases: protein kinase Cindependent transient inhibition and protein kinase C-dependent sustained inhibition.Keywords: Smooth muscle (intestinal), Acetylcholine, Carbachol, Phorbol ester, Protein kinase C It has been shown that acetylcholine and carbachol induce contraction by increasing the Ca2+ influx in intestinal smooth muscle (1). Higher concentrations of acetylcholine and carbachol also stimulate phosphoinositide turnover (2-4), and one of the hydrolysis products, inositol 1,4,5-trisphosphate, releases Ca2+ to induce transient contraction (5).We have previously reported that high concentrations of carbachol inhibit the sustained contraction induced by carbachol itself by a decrease of cytosolic Ca2+ in the intestinal smooth muscle of guinea pig taenia caeci. We have also reported that high concentrations of carbachol inhibit high K+ induced contraction (6). Phorbol ester, 12-deoxyphorbol 13-isobutyrate, also inhibited high K+-induced contraction, and this effect was abolished when the protein kinase C was desensitized (7). These results suggest that the inhibitory effect of a high concentration of carbachol on high K+-induced contraction may be Male guinea pigs, weighing 250-300 g, were killed by a blow on the neck and bled. A section of taenia (5 -10 mm in length) was dissected from the caecum. For the desensitization of protein kinase C, the muscle strips were incubated in Dulbecco's modified Eagle ...

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“…In a longitudinal muscle preparation from guinea pig ileum, bassianalodie almost irreversibly inhibited an isotonic contraction induced by acetylcholine and made the dose-response curve shift in parallel to the right (pA = 7.6). It also inhibited the contractions induced by carbachol, pilocarpine, histamine, 5-hydroxytriptamine, and prostaglandin E2, but did not inhibit the contraction induced by barium or a high concentration (40-60 mM) of potassium (Nakajyo et al, 1982). Bassianolide as a highly significant virulence factor of Bb (Xu et al, 2009) and an interesting candidate for future structural modification (Jirakkakul et al, 2008).…”

Section: Bassianolidementioning

confidence: 91%

BIOACTIVE METABOLITES OF ENTOMOPATHOGENIC FUNGI Beauveria bassiana

Patočka¹

2016

Mil. Med. Sci. Lett.

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SummaryBeauveria bassiana is a fungus which causes disease in insects. Currently it is used as an insecticide to control pest populations. Fungi are known to produce a vast array of secondary metabolites that are important for biotechnological applications. Furthemore, B. bassiana is an interesting source of biologically active molecules. There are alkaloids with the structure of 2-pyridone, dibenzoquinone pigments and different cyclodepsipeptides. Cyclodepsipeptides from B. bassiana are interesting for their neuroprotective properties. Interest of psychopharmacology is focused on the group of beauveriolides. Plant B. bassiana becomes a candidate for the prevention and treatment of neurodegenerative diseases.

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Inhibitory effect of bassianolide, a cyclodepsipeptide, on drug-induced contractions of isolated smooth muscle preparations.

Abstract: Bassianol1de

Cited by 11 publications

References 22 publications

On the inhibitory mechanism of bassianolide, a cyclodepsipeptide, in acetylcholine-induced contraction in guinea-pig taenia coli.

On the inhibitory mechanism of bassianolide, a cyclodepsipeptide, in acetylcholine-induced contraction in guinea-pig taenia coli.

Carbachol but Not Acetylcholine Inhibits Contraction by the Protein Kinase C-Dependent and -Independent Pathways in the Smooth Muscle of Guinea Pig Taenia Caeci

BIOACTIVE METABOLITES OF ENTOMOPATHOGENIC FUNGI Beauveria bassiana

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