BIOACTIVE METABOLITES OF ENTOMOPATHOGENIC FUNGI Beauveria bassiana

Patočka, Jiří

doi:10.31482/mmsl.2016.015

Cited by 32 publications

(22 citation statements)

References 55 publications

(34 reference statements)

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“…At the same time, biocontrol fungi such as Beauveria and Trichoderma spp. are producers of enormous amounts of useful metabolites [69,70]. Therefore, an approach of simultaneous production of spores and useful metabolites shown in this study can be applied for many biocontrol microorganisms in the future.…”

Section: Discussionmentioning

confidence: 94%

Isolation and Bioactivity of Secondary Metabolites from Solid Culture of the Fungus, Alternaria sonchi

et al. 2020

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The fungus, Alternaria sonchi is considered to be a potential agent for the biocontrol of perennial sowthistle (Sonchus arvensis). A new chlorinated xanthone, methyl 8-hydroxy-3-methyl-4-chloro-9-oxo-9H-xanthene-1-carboxylate (1) and a new benzophenone derivative, 5-chloromoniliphenone (2), were isolated together with eleven structurally related compounds (3–13) from the solid culture of the fungus, which is used for the production of bioherbicidal inoculum of A. sonchi. Their structures were determined by spectroscopic (mostly by NMR and MS) methods. Alternethanoxins A and B, which were reported in A. sonchi earlier, were re-identified as moniliphenone and pinselin, respectively. The isolated compounds were tested for phytotoxic, antimicrobial, insecticidal, cytotoxic and esterase-inhibition activities. They did not demonstrate high phytotoxicity (lesions up to 2.5 mm in diameter/length at a concentration of 2 mg/mL) when tested on leaf disks/segments of perennial sowthistle (Sonchus arvensis) and couch grass (Elytrigia repens). They did not possess acute toxicity to Paramecium caudatum, and showed moderate to low cytotoxicity (IC50 > 25 µg/mL) for U937 and K562 tumor cell lines. However, chloromonilicin and methyl 3,8-dihydroxy-6-methyl-4-chloro-9-oxo-9H-xanthene-1-carboxylate (4) were shown to have antimicrobial properties with MIC 0.5–5 µg/disc. Compound 4 and chloromonilinic acid B were found to have contact insecticidal activity to wheat aphid (Schizaphis graminum) at 1 mg/mL. Compounds 2 and methyl 3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate displayed selective carboxylesterase inhibition activity at concentration of 100 µg/mL. Therefore, the waste solid substrate for production of A. sonchi spores can be re-utilized for the isolation of a number of valuable natural products.

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Section: Discussionmentioning

confidence: 94%

Isolation and Bioactivity of Secondary Metabolites from Solid Culture of the Fungus, Alternaria sonchi

et al. 2020

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“…3 B and C), with the portion amide of the tyrosine (Molnár et al, 2010). These pigments are produced by B. bassiana and B. tenella (Patocka, 2016).…”

Section: Tenellin and Bassianin: Pigments Derived From 2-pyridonementioning

confidence: 99%

“…In addition, it produces the non-peptide red pigment oosporein which are biologically active metabolite that have not been reported to enter the food chain or accumulate in the environment. Also, it presents low toxicity in humans (Amin et al, 2010;Chávez-Ibañez et al, 2014;Patocka, 2016;Vega et al, 2008). These metabolites are not essential for B. bassiana growth and development.…”

Section: General Overview On the Pathogenesis Of Beauveria Bassianamentioning

confidence: 99%

“…Beauveria bassiana can secrete small molecules derived from secondary metabolism once an infection begins in different organisms to generate a toxic response (Valencia et al, 2011). Once germinal tube penetrated the cuticle of the insect the blastospores releases some toxins that contribute to the death of the insect by modulating both the cellular and humoral immune response and decreasing the insect's nutrient and microbial load (Patocka, 2016;Ortiz-Urquiza & Keyhani, 2016;Mc Namara et al, 2019) such as the case of oosporein who is not directly related to the pathogenicity mechanism of B. bassiana but has antimicrobial activity against insect microbiota (Fan et al, 2017).…”

Section: Response Mechanisms Of B Bassiana For the Synthesis Of Metamentioning

confidence: 99%

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Beauveria bassiana secondary metabolites: a review inside their production systems, biosynthesis, and bioactivities

Ávila‐Hernández¹,

Carrillo-Inungaray²,

Quiroz³

et al. 2020

Mexjbiotechnol

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The application of entomopathogenic fungi as biological control agent is an activity that has been carried out for a long time because they can regulate insect pests through specific formulations of spores and blastospores as infective units, as well as their endophytic ability in some plants offers protection against plant pathogens. Due to its wide distribution and antagonistic ability, Beauveria bassiana is widely used all around the world. Among its main mechanisms of infection is the REVIEW ARTICLE

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“…Beauvericin (BEA) (Figure 1 ) is a cyclic hexadepsipeptide that is synthesized by various toxigenic fungi, including several Fusarium species (Wang and Xu, 2012 ; Tao et al, 2015 ; Patocka, 2016 ). BEA can be produced by different Fusarium species in different regions.…”

Section: Introductionmentioning

confidence: 99%

A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin

Patočka

Nepovimová

et al. 2018

Front. Pharmacol.

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Beauvericin (BEA) is an emerging Fusarium mycotoxin that contaminates food and feeds globally. BEA biosynthesis is rapidly catalyzed by BEA synthetase through a nonribosomal, thiol-templated mechanism. This mycotoxin has cytotoxicity and is capable of increasing oxidative stress to induce cell apoptosis. Recently, large evidence further shows that this mycotoxin has a variety of biological activities and is being considered a potential candidate for medicinal and pesticide research. It is noteworthy that BEA is a potential anticancer agent since it can increase the intracellular Ca2+ levels and induce the cancer cell death through oxidative stress and apoptosis. BEA has exhibited effective antibacterial activities against both pathogenic Gram-positive and Gram-negative bacteria. Importantly, BEA exhibits an effective capacity to inhibit the human immunodeficiency virus type-1 integrase. Moreover, BEA can simultaneously target drug resistance and morphogenesis which provides a promising strategy to combat life-threatening fungal infections. Thus, in this review, the synthesis and the biological activities of BEA, as well as, the underlying mechanisms, are fully analyzed. The risk assessment of BEA in food and feed are also discussed. We hope this review will help to further understand the biological activities of BEA and cast some new light on drug discovery.

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BIOACTIVE METABOLITES OF ENTOMOPATHOGENIC FUNGI Beauveria bassiana

Cited by 32 publications

References 55 publications

Isolation and Bioactivity of Secondary Metabolites from Solid Culture of the Fungus, Alternaria sonchi

Isolation and Bioactivity of Secondary Metabolites from Solid Culture of the Fungus, Alternaria sonchi

Beauveria bassiana secondary metabolites: a review inside their production systems, biosynthesis, and bioactivities

A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin

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