Inhibitory effect of aluminium on calcium absorption in small intestine of rats with different thyroid hormone status

Orihuela, Daniel

doi:10.1016/j.jinorgbio.2009.07.017

Cited by 11 publications

(5 citation statements)

References 29 publications

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“…Orihuela [14] mentioned that this finding suggest that Al may change the pituitary endocrine regulation of thyroid gland. Orihuela [43] stated that short term oral Al, reduced thyroxin serum levels in rats. However, in his further study which was done to evaluate the effects of Al on thyroid function in adult wistar rats found that fT4and TSH remain unchanged.…”

Section: Discussionmentioning

confidence: 99%

Implication of aluminum in exerting some health disorders among exposed workers

Beshir

Shaheen²,

Eltahlawy

2021

Egypt. J. Chem.

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The present study aimed to evaluate implication of aluminum in exerting male reproductive and thyroid hormonal disorders and lipid profile changes among aluminum workers. Cross-sectional study was carried on 56 male aluminum workers in aluminum welding factory. Aluminum dust level was measured and questionnaire was conducted for all participants. Urinary aluminum level, serum total cholesterol, triglycerides, high density lipoprotein, high sensitive c-reactive protein, apolipoprotein-E, total antioxidant capacity, malondialdehyde, luteinizing hormone, follicle stimulating hormone, testosterone,17-beta-estradiol, free triiodothyronine, free thyroxin and thyroid stimulating hormone were measured in both groups. Aluminum dust mean concentration was 1.6 ± 0.3 mg/m 3 in the present study. Urinary aluminum, serum triglycerides, very low density lipoprotein cholesterol, high sensitive C-reactive protein and malondialdehyde levels were significantly higher while total antioxidant capacity was significantly lower among the exposed workers compared to controls. Serum follicle stimulating hormone and free triiodothyronine were significantly higher while free thyroxin was significantly lower in the exposed group compared to controls. No effect of smoking on all measured parameters was reported except for luteinizing hormone. Negative correlation was found between duration of exposure and 17-beta-estradiol. Urinary aluminum level was negatively correlated with total antioxidant capacity on one side and positively correlated with malondialdehyde on other side. Induction of oxidative stress and inflammation might be the possible mode of action by which aluminum exert male reproductive hormonal disorders and lipid profile changes. Aluminum may disrupt thyroid hormones. Pro inflammatory effect of aluminum was verified by the inflammatory markers.

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Section: Discussionmentioning

confidence: 99%

Implication of aluminum in exerting some health disorders among exposed workers

Beshir

Shaheen²,

Eltahlawy

2021

Egypt. J. Chem.

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“…Further, hyperthyroidism associated with release of growth hormone, glucagon, and catecholamine, which also contributes to the impaired glucose tolerance [68][69]. Another mechanism explaining the relationship between hyperthyroidism and hyperglycemia is increase in intestinal glucose absorption mediated by the excess TH [70][71]. Lipid Metabolism TH affect lipoprotein metabolism.…”

Section: *Correspondencementioning

confidence: 99%

Association of Diabetes Mellitus and Thyroid Disorders: A Metabolic Prospective

Mishra¹,

Relatado-Sotto²,

Panta³

et al. 2017

APJHS

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The prevalence of diabetes has nearly doubled since 1980, mounting from 4.7% to 8.5% in overall adult population. Thyroid disorder is another common endocrine disorder with prevalence of hypothyroidism as much as 4.6% and hyperthyroidism as much as 1.3% in population according to the National Health and Nutrition Examination Survey. These two most common endocrinopathies often co-exist and mutually influence each other. They have complex links of abnormal biochemical pathways, unregulated genetic expression of many genes and hormonal malfunctions. Thyroid hormones affects the regulation of carbohydrate metabolism, lipid metabolism and pancreatic function, and on the other hand, diabetes affects thyroid function tests to variable extents. In this review article we emphasized the epidemiology of diabetes and thyroid disorders, classification of thyroidism, and finally the impact of thyroidism to the various aspects of glucose and lipid metabolism in diabetics.

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“…In addition, Al would decrease the intestinal glutathione (GSH) level affecting CB function and/or synthesis, which would lead to a reduced transcellular Ca absorption. Apparently, the inhibitory effect of Al varies according to thyroid hormone status ( 136 ) . In late pregnancy and mainly during the middle lactation of rats, Al has also been shown to reduce transcellular Ca absorption in the duodenum by interfering with the mechanisms of Ca transport partially mediated by a high serum level of oestrogen and prolactin ( 137 ) .…”

Section: Nutritional Factors Affecting Intestinal Calcium Absorptionmentioning

confidence: 99%

Dietary and pharmacological compounds altering intestinal calcium absorption in humans and animals

et al. 2015

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The intestine is the only gate for the entry of Ca to the body in humans and mammals. The entrance of Ca occurs via paracellular and intracellular pathways. All steps of the latter pathway are regulated by calcitriol and by other hormones. Dietary and pharmacological compounds also modulate the intestinal Ca absorption process. Among them, dietary Ca and P are known to alter the lipid and protein composition of the brush-border and basolateral membranes and, consequently, Ca transport. Ca intakes are below the requirements recommended by health professionals in most countries, triggering important health problems. Chronic low Ca intake has been related to illness conditions such as osteoporosis, hypertension, renal lithiasis and incidences of human cancer. Carbohydrates, mainly lactose, and prebiotics have been described as positive modulators of intestinal Ca absorption. Apparently, high meat proteins increase intestinal Ca absorption while the effect of dietary lipids remains unclear. Pharmacological compounds such as menadione, dl-butionine-S,R-sulfoximine and ursodeoxycholic acid also modify intestinal Ca absorption as a consequence of altering the redox state of the epithelial cells. The paracellular pathway of intestinal Ca absorption is poorly known and is under present study in some laboratories. Another field that needs to be explored more intensively is the influence of the gene × diet interaction on intestinal Ca absorption. Health professionals should be aware of this knowledge in order to develop nutritional or medical strategies to stimulate the efficiency of intestinal Ca absorption and to prevent diseases.

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Inhibitory effect of aluminium on calcium absorption in small intestine of rats with different thyroid hormone status

Cited by 11 publications

References 29 publications

Implication of aluminum in exerting some health disorders among exposed workers

Implication of aluminum in exerting some health disorders among exposed workers

Association of Diabetes Mellitus and Thyroid Disorders: A Metabolic Prospective

Dietary and pharmacological compounds altering intestinal calcium absorption in humans and animals

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