Inhibitory B cell co-receptors and autoimmune diseases

Tsubata, Takeshi

doi:10.1080/25785826.2019.1660038

Cited by 19 publications

(14 citation statements)

References 73 publications

(117 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The binding of sialic acid ligands to immune inhibitory siglecs results in immune evasion [40][41][42]. For example, blocking siglec-2 (CD22), an inhibitory B cell receptor specifically recognizing α2,6 sialic acids, increased tumor sensitivity towards immunotherapy [43][44][45]. Similarly, inhibiting siglec-7 and siglec-9 could protect tumor cells from NK cell responses [46].…”

Section: Sialic Acids Facilitate Immune Escapementioning

confidence: 99%

Biological Functions and Analytical Strategies of Sialic Acids in Tumor

Zhou

Yang

Guan

2020

Cells

119

View full text Add to dashboard Cite

Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell–cell communication, bacterial and viral infections. In particular, hypersialylation in tumors, as well as their roles in tumor growth and metastasis, have been widely described. Recent studies have indicated that the aberrant sialylation is a vital way for tumor cells to escape immune surveillance and keep malignance. In this article, we outline the present state of knowledge on the metabolic pathway of human sialic acids, the function of hypersialylation in tumors, as well as the recent labeling and analytical techniques for sialic acids. It is expected to offer a brief introduction of sialic acid metabolism and provide advanced analytical strategies in sialic acid studies.

show abstract

Section: Sialic Acids Facilitate Immune Escapementioning

confidence: 99%

Biological Functions and Analytical Strategies of Sialic Acids in Tumor

Zhou

Yang

Guan

2020

Cells

119

View full text Add to dashboard Cite

show abstract

“…It is expressed on human leucocytes, including B cells, eosinophils, monocytes, dendritic cells, T cells and NK cells [10][11][12][13][14]. Studies have shown that Siglec-10 plays an important role in regulating the immune balance of in ammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Long-term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage

S¹,

Peng²,

Chen³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background The presence of aneurysmal subarachnoid hemorrhage (aSAH) is usually accompanied by excessive inflammatory response leading to the destruction of central nervous system, while the sialic acid-binding Ig-like lectin 10 (Siglec-10) is a factor recognized as having the ability to modify the inflammatory microenvironment, indicating a potential protective effect in aSAH. Methods We collected the cerebrospinal fluid (CSF) of control group and aSAH patients at different time points, measured the Siglec-10 concentration by the enzyme-linked immunosorbent assay (ELISA), and evaluated the changes of Glasgow Outcome Scale (GOS) and Glasgow Coma Scale (GCS) in the disease progression. Results Our data showed that the Siglec-10 level in CSF could respond to aSAH and quickly rose to a peak, then fell back to a stable range slightly higher than the normal range. Severely impaired patients were likely to maintain high levels of Siglec-10 for longer periods. Generally, having high-level and long-term Siglec-10 indicated a better prognosis. Conclusions These results suggested that Siglec-10 could possibly reduce the degree of inflammatory response related to the damage-associated molecular patterns (DAMPs) by regulating the balance between pro-inflammatory and anti-inflammatory, thereby improving the patient's prognosis. These findings might provide new treatment perspectives for aSAH and other inflammation-related diseases.

show abstract

“…Currently, many autoimmune diseases could be regulated by various immune cells. For instance, CD22 and CD72 inhibited the proliferation of regulatory B cells, which can regulate MS and type 1 diabetes mellitus (T1D) ( Tsubata, 2019 ). Understanding the role of various immune cells in different autoimmune diseases can help enrich treatment options.…”

Section: Overview Of Autoimmune Diseasesmentioning

confidence: 99%

The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases

et al. 2021

View full text Add to dashboard Cite

Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a cluster of diseases accompanied with tissue damage caused by autoimmune reactions, including rheumatoid arthritis (RA), psoriasis, etc. This review summarized the links between IL-38 and autoimmune diseases, as well as the latest knowledge about the function and regulatory mechanism of IL-38 in autoimmune diseases. Especially, this review focused on the differentiation of immune cells and explore future prospects, such as the application of IL-38 in new technologies. Understanding the function of IL-38 is helpful to shed light on the progress of autoimmune diseases.

show abstract

Inhibitory B cell co-receptors and autoimmune diseases

Cited by 19 publications

References 73 publications

Biological Functions and Analytical Strategies of Sialic Acids in Tumor

Biological Functions and Analytical Strategies of Sialic Acids in Tumor

WITHDRAWN: Long-term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage

The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases

Contact Info

Product

Resources

About