Inhibitory Activity of Allergic Contact Dermatitis and Atopic Dermatitis-Like Skin in BALB/c Mouse through Oral Administration of Fermented Barks of Alnus sibirica

Abstract

Phytochemical isolation of fermented Alnus sibirica (FAS) which was produced by using Lactobacillus plantarum subsp. argentoratensis, exhibited multiple and different composition compared with the original plant. Anti-allergic contact dermatitis (anti-ACD)/anti-atopic dermatitis (anti-AD) activities (visual observation and regulation of Th1/Th2 cytokines and IgE in blood) of FAS and the barks of Alnus sibirica extract (AS) and the two diarylheptanoids, hirsutenone (1) and muricarpon B (2), which are major components of FAS, were measured in vitro and in vivo. FAS, AS and the two compounds showed potent anti-oxidative, anti-inflammatory, anti-ACD and anti-AD activity. In particular, FAS showed more potent biological activity than AS. Thus, fermentation might be a prominent way to enhance the biological activity compared with the original plant. In addition, compounds (1) and (2) might be developed as functional materials or herbal medicines for ACD and AD.

Inhibitory Effects on NO Production and DPPH Radicals and NBT Superoxide Activities of Diarylheptanoid Isolated from Enzymatically Hydrolyzed Ehthanolic Extract of Alnus sibirica

“…From our previous study, 17 compounds from fermented AS (FAS) were isolated and evaluated for their antioxidant, anti-inflammatory, and anti-atopic dermatitis activities, in vitro and in vivo, including the quantitative analysis of its components [23,24,25]. The present paper describes the evaluation of antioxidant and anti-inflammatory effects on the enzymatic hydrolysis (EAS).…”

Alnus Sibirica Extracts Suppress the Expression of Inflammatory Cytokines Induced by Lipopolysaccharides, Tumor Necrosis Factor-α, and Interferon-γ in Human Dermal Fibroblasts

“…It has been reported that they have antioxidant, anti-inflammatory [58], anti-atopic dermatitis [63], and cytotoxic [64] properties. Lee et al [65] reported that the oral administration of fermented AS extracts (FAS) reduced the expression of IgE, IL-4, and IFN-γ in splenocytes from BALB/c mice with atopic-like dermatitis. However, they reported only the mitigating effects on systemic inflammation and did not describe the effects of AS extracts on the various cytokines associated with skin inflammation.…”

Pediococcus pentosaceus-Fermented Cordyceps militaris Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis

“…Allergic contact dermatitis (ACD), a chronic inflammatory skin disease, is a type IV delayed-hypersensitivity response induced by sensitization to allergens that causes redness, edema, and dryness of the skin [ 1 , 2 ]. Furthermore, the prevalence of ACD in children and adults worldwide is 15–20% and 1–3%, respectively [ 3 , 4 , 5 ]. The prevalence rate of ACD is higher in young children under 10 years than it is adults [ 3 , 6 ].…”

“…Furthermore, the prevalence of ACD in children and adults worldwide is 15–20% and 1–3%, respectively [ 3 , 4 , 5 ]. The prevalence rate of ACD is higher in young children under 10 years than it is adults [ 3 , 6 ]. Systemic corticosteroid or steroids combined with methotrexate, and azathioprine have been used for ACD [ 7 ].…”

“…However, long-term use of these drugs can cause unwanted side effects such as diabetes, hypertension, myelosuppression, infections, and ulcer [ 7 ]. Therefore, there is a need to develop novel agents, preferably from natural products, to treat ACD [ 3 ].…”