Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes

Juergens, Uwe R.; Engelen, Tanja; Racké, Kurt; Stöber, Meinolf; Gillissen, Adrian; Vetter, Hans

doi:10.1016/j.pupt.2004.06.002

Cited by 195 publications

(138 citation statements)

References 18 publications

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“…Thus, drugs that inhibit these cytokines production may play an important role in the control of inflammation. 31,32) Studies have indicated that lactoferrin and b-amyloid peptides inhibited cytokines (TNF-a, IL-4, IL-6 and IL-8) production in LPS-stimulated THP-1 cells. 7,8) In this study, TET showed inhibitory effect on TNF-a, IL-4 and IL-8 expression in the same cells induced by LPS.…”

Section: Discussionmentioning

confidence: 99%

Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX-2 Expression in Human Monocytic Cells

2007

Biological & Pharmaceutical Bulletin

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Section: Discussionmentioning

confidence: 99%

Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX-2 Expression in Human Monocytic Cells

2007

Biological & Pharmaceutical Bulletin

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“…Cytokine production in monocytes of TNF-α, IL-1β, IL-6, IL-8 was also significantly (P< 0.001) inhibited by 99, 84, 76, and 65%, respectively. In the presence of 1,8-cineol (0.15 μg/ml=10−6 M), the production of TNF-α and IL-1β by monocytes and lymphocytes was significantly inhibited by 77, 61 and 16, 36%, respectively [116]. The effect of Eucalyptus essential oils (EO) was studied on the phagocytic ability of human monocyte derived macrophages (MDMs) in vitro and of rat peripheral blood monocytes/granulocytes in vivo in absence or in presence of immuno-suppression induced by the chemotherapeutic agent 5-fluorouracil (5-FU).…”

Section: Antiinflammatory and Analgesic Effectmentioning

confidence: 99%

The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Eucalyptus species grown in Iraq were included Eucalyptus bicolor (Syn: Eucalyptus largiflorens), Eucalyptus griffithsii, Eucalyptus camaldulensis (Syn: Eucalyptus rostrata) Eucalyptus incrassate, Eucalyptus torquata and Eucalyptus microtheca (Syn: Eucalyptus coolabahs). Eucalypts contained volatile oils which occurred in many parts of the plant, depending on the species, but in the leaves that oils were most plentiful. The main constituent of the volatile oil derived from fresh leaves of Eucalyptus species was 1,8-cineole. The reported content of 1,8-cineole varies for 54-95%. The most common constituents co-occurring with 1,8-cineole were limonene, α-terpineol, monoterpenes, sesquiterpenes, globulol and α , β and ϒ-eudesmol, and aromatic constituents. The pharmacological studies revealed that Eucalypts possessed gastrointestinal, antiinflammatory, analgesic, antidiabetic, antioxidant, anticancer, antimicrobial, antiparasitic, insecticidal, repellent, oral and dental, dermatological, nasal and many other effects. The current review highlights the chemical constituents and pharmacological and therapeutic activities of Eucalyptus species grown in Iraq.

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“…It has strong healing potential. It has anti-inflammatory (Santos & Rao 2000;Juergens et al 2003;Juergens et al 2004;Santos et al 2004), antibacterial, (Lahlou et al 2002). Ramla and Varalangi from Kalimpong (West Bengal), Sawney from Nagaland and Burma had high cineole content where as the cultivars from Sikkim recorded low 1,8-cineole and high α-and β-pinenes.…”

Section: Gc-ms Profile Of Large Cardamom Oil Is Shown Inmentioning

confidence: 99%

Volatile oil composition of four popular varieties of large cardamom (Amomum subulatum Roxb.)

Vijayan

Leela

Dhanalakshmi

et al. 2017

J Spices Aromatic Crops

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In the present study volatile oil profile of the four popular varities of large cardamom (Amomum subulatum Roxb.) namely Sawney, Varlangey, Ramla and Ramsey were studied in detail. The capsules contained 58.1-68.1% seeds and 1.2-2.8% essential oil. By GC-MS analysis 23 constituents of the oil were identified with 1, 8-cineole as the chief component. Major constituents of the oil were α-pinene (1.7-6.5%), β -pinene (4.0-11.1%), 1, 8-cineole (63.2-73.4%) and α-terpineol (5.6-7.6%). The oil contained high level of 1, 8-cineole when compared to small cardamom (Elettaria cardamom Maton). α -Terpinyl acetate, the chief component of small cardamom oil was not detected in large cardamom.

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Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes

Cited by 195 publications

References 18 publications

Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX-2 Expression in Human Monocytic Cells

Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX-2 Expression in Human Monocytic Cells

The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq

Volatile oil composition of four popular varieties of large cardamom (Amomum subulatum Roxb.)

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