Inhibitory actions of bisabolol on α7-nicotinic acetylcholine receptors

Nurulain, Syed M.; Prytkova, Tatiana; Sultan, Ahmed; Ievglevskyi, Oleksandr; Lorke, Dietrich; Yang, Kechun; Petroianu, Georg; Howarth, Frank Christopher; Kabbani, Nadine; Öz, Murat

doi:10.1016/j.neuroscience.2015.08.019

Cited by 17 publications

(14 citation statements)

References 40 publications

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“…It is used in making tea and in the cosmetics industry. It has anti‐inflammatory effects in the skin, as well as anti‐nociceptive and neuroprotective benefit . It was a pro‐apoptotic agent for primary human acute leukemia cells and glioma cells in both humans and rats, breast cancer, highly malignant human pancreatic carcinoma cell lines, and anti‐mutagenic/antioxidant .…”

Section: Terpenes (Terpenoids)mentioning

confidence: 99%

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

2018

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There is accumulating evidence for various therapeutic benefits of cannabis/cannabinoids, especially in the treatment of pain, which may also apply to the treatment of migraine and headache. There is also supporting evidence that cannabis may assist in opioid detoxification and weaning, thus making it a potential weapon in battling the opioid epidemic. Cannabis science is a rapidly evolving medical sector and industry with increasingly regulated production standards. Further research is anticipated to optimize breeding of strain-specific synergistic ratios of cannabinoids, terpenes, and other phytochemicals for predictable user effects, characteristics, and improved symptom and disease-targeted therapies.

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Section: Terpenes (Terpenoids)mentioning

confidence: 99%

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

2018

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“…Savalev et al (2003) observed synergistic interactions among the components (1.8-cineole, camphor, α-pinene, β-pinene, borneol, caryophyllene oxide, linalool and bornyl acetate) which come from the species Salvia lavandulaefolia. Among those components mentioned above was found the essential oil of B. ungulata in the presence of α-pinene, β-pinene and caryophyllene oxide; certainly there was synergism of compounds present in the oil of the species studied by high inhibition of the enzyme, highlighting the chemical components β-caryophyllene and α-bisabolol, which has a close relationship with neurodegenerative diseases and reported by Nurulain et al (2015), Ferreira (2014), Alcantara et al (2010) and Santos et al (2015).…”

Section: Resultsmentioning

confidence: 62%

“…According to Nurulain et al (2015), the compound binds directly to the receptor a7-nAChRs, leading to inhibition of acetylcholine.…”

Section: Resultsmentioning

confidence: 99%

Chemical profile, antimicrobial activity, toxicity on Artemia salina and anti-acetylcholinesterase enzyme essential oil from Bauhinia ungulata L. (Fabaceae) leaves

Medeiros¹,

Filho²,

Costa³

et al. 2016

J. Med. Plants Res.

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Bauhinia ungulata L. species, belongs to the genus Bauhinia, popularly known as pata de vaca, is among the species of medicinal employ in Brazil, used to treat diabetes. The aim of this study was to characterize the chemical composition, antimicrobial activity, toxicity on Artemia salina and acetylcholinesterase enzyme inhibition by essential oil from B. ungulata L. The chromatographic analysis revealed 18 components, the majority were the β-caryophyllene (15.9%), caryophyllene oxide (9.2%), α-humulene (8.1%), epi-γ-eudesmol (7.5%), α-bisabolol (4.7%), copaene (3.5%), nerolidol (3.3%), α-bisabolol oxide B (2.5%), spathulenol (2.1%). The essential oil showed high toxicity compared to the tests with Artemia salina and inhibited 95.96%±0.62 of the acetylcholinesterase enzyme. The microorganisms show antimicrobial inhibition with Candida albicans (85%), Bacillus cereus (65.5%) and Staphylococcus aureus (66.4%), Salmonella typhimurium (68.7%) and Citrobacter freundii (46.1%). The oil showed great potential when tested in bioassays.

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“…By the use of imaging, electrophysiological and biochemical methods, Nurulain and collaborators [ 116 ] showed that (−)-α-bisabolol reversibily and dose-dependently suppressed α7-nicotinic acetylcholine receptors (α7-nChRs) mediated currents in oocytes of Xenopus laevis . These receptors are found in the peripheral and central nervous system and are characterized by rapid desensitization and high permeability to calcium [ 117 ].…”

Section: Resultsmentioning

confidence: 99%

Analgesic-Like Activity of Essential Oil Constituents: An Update

Sá

Lima

Nóbrega

et al. 2017

IJMS

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The constituents of essential oils are widely found in foods and aromatic plants giving characteristic odor and flavor. However, pharmacological studies evidence its therapeutic potential for the treatment of several diseases and promising use as compounds with analgesic-like action. Considering that pain affects a significant part of the world population and the need for the development of new analgesics, this review reports on the current studies of essential oils’ chemical constituents with analgesic-like activity, including a description of their mechanisms of action and chemical aspects.

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Inhibitory actions of bisabolol on α7-nicotinic acetylcholine receptors

Cited by 17 publications

References 40 publications

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

Chemical profile, antimicrobial activity, toxicity on Artemia salina and anti-acetylcholinesterase enzyme essential oil from Bauhinia ungulata L. (Fabaceae) leaves

Analgesic-Like Activity of Essential Oil Constituents: An Update

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