Inhibitors of Dopamine- -Hydroxylase in Human Plasma

Harralson, J. D.; Brown, Fountaine C.

doi:10.3181/00379727-149-38870

Cited by 6 publications

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“…It is not sufficient, however, to measure enzyme activity only with one substrate or substrate concentration (2). More• over, inhibitors which can mask the actual activity of cer• tain enzymes, are present in tissues and serum (10,15,17).…”

Section: Discussionmentioning

confidence: 99%

“…Measurement of enzyme activity in blood drawn from patients often was carried out with only one substrate at only one concentration and without properly matched control groups. Better methods are required in order to obtain reliable information in enzyme kinetics (2,10,15,17). In partiCular, it is of interest to determine bot Km and V of enzymes in patients and matched controls (2).…”

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confidence: 99%

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Serum DBH and Platelet MAO in Patients with Depressive Disorders

Honecker¹,

Fähndrich²,

Coper³

et al. 1981

Pharmacopsychiatry

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Km and V of serum dopamine-beta-hydroxylase and platelet monoamine-oxidase (MAO) were determined in the depressive and manic state as well as after recovery in patients with affective psychoses and in the depressive state of patients with neurotic depression. DBH and MAO values were measured also in age- and sex-matched controls. The Km and V values of each enzyme failed to differ between patients and healthy controls or between patients during and after an episode of illness. The ratio of V of serum DBH (tyramine as substrate) tended to be lower in patients independent of their psychopathological state than in controls. The findings fail to support the notion that characteristics of the peripheral enzymes measured provides a reliable indicator of a biological disposition to depression, but are consistent with the notion that the balance of monoamine may play a role in certain psychopathological states.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Serum DBH and Platelet MAO in Patients with Depressive Disorders

Honecker¹,

Fähndrich²,

Coper³

et al. 1981

Pharmacopsychiatry

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The inhibitory effect of serum from diethyldithiocarbamate treated rats on bovine adrenal dopamine‐β‐hydroxylase activity

Jarvis

Magós

Jacobs

1981

J of Applied Toxicology

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The activity of serum dopamine-beta-hydroxylase does not depend solely on the presence of exogenous inhibitors: its activity also depends on the rate of release into plasma and is influenced by sympathetic activity or pathological conditions. This fluctuation may disguise the effect of an exogenous inhibitor on the enzyme. It has been shown in the present work that boiling of serum obtained from sodium diethyldithiocarbamate treated rats did not eliminate the dopamine-beta-hydroxylase inhibitory effect on a bovine adrenal dopamine-beta-hydroxylase preparation. Thus it is possible to measure the dopamine-beta-hydroxylase inhibitory effect of an exogenous inhibitor of this type without interference from the enzyme present in serum. Serum taken from rats treated with sodium diethyldithiocarbamate depressed in a time and dose dependent way the activity of bovine adrenal dopamine-beta-hydroxylase preparation.

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Serial studies of serum dopamine‐B‐hydroxylase and urinary vanillylmandelic and homovanillic acids in neuroblastoma

Brewster¹,

Berry²

1979

Med. Pediatr. Oncol.

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Recent reports have suggested that elevations of serum dopamine-B-hydroxylase (DBH) activity may correlate with diagnosis in neuroblastoma patients excreting vanillylmandelic acid (VMA). We have serially studied serum DBH and urinary homovanillic acid (HVA) and VMA excretion during the disease course of five patients with neuroblastoma. DBH activities did not indicate clinical course, therapies, or prognosis. Dilution studies revealed an age-related alteration in DBH effectors and they suggest that these may be different in neuroblastoma.

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Inhibitors of Dopamine- -Hydroxylase in Human Plasma

Cited by 6 publications

References 0 publications

Serum DBH and Platelet MAO in Patients with Depressive Disorders

Serum DBH and Platelet MAO in Patients with Depressive Disorders

The inhibitory effect of serum from diethyldithiocarbamate treated rats on bovine adrenal dopamine‐β‐hydroxylase activity

Serial studies of serum dopamine‐B‐hydroxylase and urinary vanillylmandelic and homovanillic acids in neuroblastoma

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