Inhibitors and antagonists of bacterial quorum sensing

Ni, Nanting; Li, Minyong; Wang, Junfeng; Wang, Binghe

doi:10.1002/med.20145

Cited by 189 publications

(142 citation statements)

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“…In recent past, many sources were explored for QSI, and few with the potential to inhibit various pathogens were reported from plants, synthetic chemicals and microbes [3][4][5][6][7]. Because of the increasing rate of rediscovery of known drugs from terrestrial sources, marine microorganisms have gained much attention, since many remain unexplored [8].…”

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confidence: 99%

Anti-pathogenic Potential of Coral Associated Bacteria Isolated from Gulf of Mannar Against Pseudomonas aeruginosa

2012

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Infections of Pseudomonas aeruginosa are of great concern because of its increasing resistance towards conventional antibiotics. Quorum sensing system of P. aeruginosa acts as a global regulator of almost all the virulence factors and majorly its biofilm formation. In the present study, quenching of QS system of P. aeruginosa has been explained with bioactives from bacteria associated with the coral Acropora digitifera. Isolated bioactives inhibited the expression of various virulence traits of P. aeruginosa like biofilm formation, and the production of extracellular enzymes like protease and elastase. This study also emphasises the potential of coral associated bacteria in producing bioactive agents with anti-pathogenic properties.Keywords Quorum sensing Á Pseudomonas aeruginosa Á Coral associated bacteria Á Biofilm Á Anti-QS Á Quorum sensing inhibitor Density dependent cell to cell communication between bacterial population known as quorum sensing (QS) is of great interest, since virulence and resistance being its major outcome in bacteria. It has been reported that QS controls the regulation of virulence and biofilm formation that are 1000-fold more resistant to antibiotics [1].Pseudomonas aeruginosa, an opportunistic pathogen causes infections in cystic fibrosis (CF), burns, wounds and pneumonia patients [1]. QS plays a major role in controlling the virulence of P. aeruginosa by regulating various virulence traits viz. LasA protease, LasB elastase, superoxide dismutase, alkaline protease, hydrogen cyanide, pyocyanin, pyoverdin, rhamnolipid and biofilm formation [1].QS being the major factor concerning enhanced virulence and broad spectrum resistance in P. aeruginosa, its inhibition will be of importance to treat infections caused by pathogenic drug resistant P. aeruginosa. Compounds with the ability to interfere the QS system of bacteria are called as QS inhibitors (QSI) or anti-pathogenic agents [2].In recent past, many sources were explored for QSI, and few with the potential to inhibit various pathogens were reported from plants, synthetic chemicals and microbes [3][4][5][6][7]. Because of the increasing rate of rediscovery of known drugs from terrestrial sources, marine microorganisms have gained much attention, since many remain unexplored [8]. In this study, coral associated bacteria (CAB) were screened for antibiofilm and anti-QS properties, since they play a defensive role in coral reefs in controlling the pathogens of the host [9].Out of 41 CAB screened, nine have shown anti-QS activity against the bioreporter strain Chromobacterium violaceum ATCC 12472 (Fig. 1a) [10]. CAB23 and 41 which showed around 90 % anti-QS activity against C. violaceum were studied further. Biofilm inhibitory concentration (BIC)-lowest concentration required to inhibit the biofilm formation-of the extracts was assessed against P. aeruginosa PAO1 with varying concentrations (5-2,500 lg mL -1 ) and found to be 1.75 mg mL -1 . Further, the activity of CAB extracts on the growth of P. aeruginosa PAO1 was studied and fou...

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Anti-pathogenic Potential of Coral Associated Bacteria Isolated from Gulf of Mannar Against Pseudomonas aeruginosa

2012

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“…[86][87][88][89] Lee et al have reported that biofilm formation was inhibited by 7-hydroxyindole and 5-hydroxyindole in E. coli. 90 It has also been reported that 4-hydroxyindole, 5-hydroxyindole, 6-hydroxyindole, and isatin inhibited not only membrane vesicle production but also Pseudomonas quinolone signal (PQS) synthesis.…”

Section: Metagenomic Screening For Quorum-sensing Inhibitorsmentioning

confidence: 99%

Metagenomic approaches to understanding phylogenetic diversity in quorum sensing

Kimura

2014

Virulence

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“…The no volatile compounds with QSI properties, like some flavonoids, malyngamide (Kwan et al, 2010), S-ribosyl-Lhomocysteine analogs (Shen et al, 2006) and macromolecules (Amara et al, 2011), are not revised. For a general revision Chan et al, 2004;Dobrestov et al, 2009;Konaklieva & Plotkin, 2006;McDougald et al, 2007;Ni et al, 2009, Rasmussen et al, 2006 and the issue number 1 of 111 th volume of The Chemical Reviews are suggested.…”

Section: Quorum Sensing Inhibitors Analysismentioning

confidence: 99%