Inhibitor of Differentiation-3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders

Doke, Mayur; Avecilla, Vincent; Felty, Quentin

doi:10.1155/2018/6821601

Cited by 16 publications

(16 citation statements)

References 146 publications

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“…As one of Inhibitor of DNA binding family, ID3 have been known to regulate cell growth, self‐renewal, senescence, angiogenesis, and neurogenesis (Doke, Avecilla, & Felty, ). The ID3 is biologically relevant to neurological and behavior research because of its involvement in the stress response, neural plasticity, and neural circuitry (Avecilla, Doke, & Felty, ).…”

Section: Discussionmentioning

confidence: 99%

Identification of key genes and upstream regulators in ischemic stroke

Zhang

Chen

et al. 2019

Brain and Behavior

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Introduction Ischemic stroke (IS) causes severe neurological impairments and physical disabilities and has a high economic burden. Our study aims to identify the key genes and upstream regulators in IS by integrated microarray analysis. Methods An integrated analysis of microarray studies of IS was performed to identify the differentially expressed genes (DEGs) in IS compared to normal control. Based on these DEGs, we performed the functional annotation and transcriptional regulatory network constructions. Quantitative real‐time polymerase chain reaction (qRT‐PCR) was performed to verify the expression of DEGs. Results From two Gene Expression Omnibus datasets obtained, we obtained 1526 DEGs (534 up‐regulated and 992 down‐regulated genes) between IS and normal control. The results of functional annotation showed that Oxidative phosphorylation and Alzheimer's disease were significantly enriched pathways in IS. Top four transcription factors (TFs) with the most downstream genes including PAX4, POU2F1, ELK1, and NKX2‐5. The expression of six genes (ID3, ICAM2, DCTPP1, ANTXR2, DUSP1, and RGS2) was detected by qRT‐PCR. Except for DUSP1 and RGS2, the other four genes in qRT‐PCR played the same pattern with that in our integrated analysis. Conclusions The dysregulation of these six genes may involve with the process of ischemic stroke (IS). Four TFs (PAX4, POU2F1, ELK1 and NKX2‐5) were concluded to play a role in IS. Our finding provided clues for exploring mechanism and developing novel diagnostic and therapeutic strategies for IS.

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Section: Discussionmentioning

confidence: 99%

Identification of key genes and upstream regulators in ischemic stroke

Zhang

Chen

et al. 2019

Brain and Behavior

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“…Further roles of endocrine disruption have been found in relation to metabolic disorders, including alteration of cholesterol metabolism, weight gain, obesity [56][57][58] and type 1 and 2 diabetes [22,59].…”

Section: Endocrine Disruptors and Human Healthmentioning

confidence: 99%

Endocrine Disruption by Mixtures in Topical Consumer Products

Ripamonti¹,

Allifranchini²,

Todeschi³

et al. 2018

Cosmetics

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Endocrine disruption has been gathering increasing attention in the past 25 years as a possible new threat for health and safety. Exposure to endocrine disruptor has been progressively linked with a growing number of increasing disease in the human population. The mechanics through which endocrine disruptors act are not yet completely clear, however a number of pathways have been identified. A key concern is the cumulative and synergic effects that endocrine disruptors could have when mixed in consumer products. We reviewed the available literature to identify known or potential endocrine disruptors, as well as endocrine active substances that could contribute to cumulative effects, in topical consumer products. The number of endocrine actives used daily in consumer products is staggering and even though most if not all are used in concentrations that are considered to be safe, we believe that the possibility of combined effects in mixtures and non-monotonic dose/response is enough to require further precautions. A combined in vitro approach based on existing, validated OECD test methods is suggested to screen consumer products and mixtures for potential interaction with estrogen and androgen hormone receptors, in order to identify products that could have cumulative effects or support their safety concerning direct endocrine disruption capabilities.

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“…The members of the ID family share an extensive amino acid sequence homology within their HLH (helix-loop-helix) domain (69–78%) [ 17 , 18 ]. It has been reported that ID protein acts as a transcription regulator, which regulate the transcription in a dominant-negative manner by dimerizing with basic HLH transcription factors like HEB, E47, and E12 [ 19 , 20 , 21 ]. ID proteins are pleiotropic proteins involved in the modulation of biological processes, such as cell proliferation and differentiation, cell cycle control, senescence, apoptosis or angiogenesis, and metastasis [ 22 , 23 ].…”

Section: Inhibitor Of Differentiationmentioning

confidence: 99%

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

et al. 2018

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The devastating growth in the worldwide frequency of neurocognitive disorders and its allied difficulties, such as decline in memory, spatial competency, and ability to focus, poses a significant psychological public health problem. Inhibitor of differentiation (ID) proteins are members of a family of helix-loop-helix (HLH) transcription factors. ID proteins have been demonstrated to be involved in neurodevelopmental and depressive diseases and, thus, may influence neurocognitive deficiencies due to environmental exposure. Previously, it has been demonstrated that environmental factors, such as estrogenic endocrine disruptors (EEDs), have played an essential role in the influence of various neurocognitive disorders such as Alzheimer’s, dementia, and Parkinson’s disease. Based on this increasing number of reports, we consider the impact of these environmental pollutants on ID proteins. Better understanding of how these ID proteins by which EED exposure can affect neurocognitive disorders in populations will prospectively deliver valuable information in the impediment and regulation of these diseases linked with environmental factor exposure.

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Inhibitor of Differentiation-3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders

Cited by 16 publications

References 146 publications

Identification of key genes and upstream regulators in ischemic stroke

Identification of key genes and upstream regulators in ischemic stroke

Endocrine Disruption by Mixtures in Topical Consumer Products

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

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