Inhibitor of complement activation attenuates placental ischemia‐induced hypertension in rat

Lillegard, Kathryn E; Johnson, A. C.; Lojovich, Sarah J.; Bauer, Ashley J.; Marsh, Henry C.; Gilbert, Jeffrey S.; Regal, Jean F.

doi:10.1096/fasebj.26.1_supplement.1097.4

Cited by 2 publications

(1 citation statement)

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“…Notably, the aberrant placentation process may be reversed by inhibiting the complement pathway using inhibitors at the maternal–foetal interface. The study by Lillegard et al [ 65 ] reported the relationship between complement activation and pregnancy hypertension, where complement inhibition slowed the evolution of high blood pressure following placental ischaemia in a rat model [ 65 ]. Furthermore, complications may arise if the complement system fails to remove ischaemic placental components [ 57 ].…”

Section: The Complement System In Preeclampsiamentioning

confidence: 99%

Is the Complement System Dysregulated in Preeclampsia Comorbid with HIV Infection?

Govender,

David,

Naicker

2024

IJMS

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South Africa is the epicentre of the global HIV pandemic, with 13.9% of its population infected. Preeclampsia (PE), a hypertensive disorder of pregnancy, is often comorbid with HIV infection, leading to multi-organ dysfunction and convulsions. The exact pathophysiology of preeclampsia is triggered by an altered maternal immune response or defective development of maternal tolerance to the semi-allogenic foetus via the complement system. The complement system plays a vital role in the innate immune system, generating inflammation, mediating the clearance of microbes and injured tissue materials, and a mediator of adaptive immunity. Moreover, the complement system has a dual effect, of protecting the host against HIV infection and enhancing HIV infectivity. An upregulation of regulatory proteins has been implicated as an adaptive phenomenon in response to elevated complement-mediated cell lysis in HIV infection, further aggravated by preeclamptic complement activation. In light of the high prevalence of HIV infection and preeclampsia in South Africa, this chapter discusses the association of complement proteins and their role in the synergy of HIV infection and preeclampsia in South Africa. It aims to identify women at elevated risk, leading to early diagnosis and better management with targeted drug therapy, thereby improving the understanding of immunological dysregulation.

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Section: The Complement System In Preeclampsiamentioning

confidence: 99%