Is the Complement System Dysregulated in Preeclampsia Comorbid with HIV Infection?
Sumeshree Govender,
Mikyle David,
Thajasvarie Naicker
Abstract:South Africa is the epicentre of the global HIV pandemic, with 13.9% of its population infected. Preeclampsia (PE), a hypertensive disorder of pregnancy, is often comorbid with HIV infection, leading to multi-organ dysfunction and convulsions. The exact pathophysiology of preeclampsia is triggered by an altered maternal immune response or defective development of maternal tolerance to the semi-allogenic foetus via the complement system. The complement system plays a vital role in the innate immune system, gene… Show more
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