Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin

Zaharudin, Nazikussabah; Stærk, Dan; Dragsted, Lars Ove

doi:10.1016/j.foodchem.2018.07.142

Cited by 76 publications

(52 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fucoxanthin from extracts of edible brown seaweed Undaria pinnatifidae inhibits α-glucosidase activity through mixed type of inhibition ( Zaharudin et al, 2019 ).…”

Section: Dietary Sources and Their Bioactive α-Glucosidase Inhibitorsmentioning

confidence: 99%

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Hossain

Das

Ghosh

et al. 2020

Food and Chemical Toxicology

226

121

View full text Add to dashboard Cite

Recently the use of bioactive α-glucosidase inhibitors for the treatment of diabetes have been proven to be the most efficient remedy for controlling postprandial hyperglycemia and its detrimental physiological complications, especially in type 2 diabetes. The carbohydrate hydrolysing enzyme, α-glucosidase, is generally competitively inhibited by the α-glucosidase inhibitors and results in the delayed glucose absorption in small intestine, ultimately controlling the postprandial hyperglycemia. Here we have reviewed the most recent updates in the bioactive α-glucosidase inhibitors category. This review provides an overview of the α-glucosidase inhibitory potentials and efficiency of controlling postprandial hyperglycemia of various bioactive compounds such as flavonoids, phenolic compound, polysaccharide, betulinic acid, tannins, anthocyanins, steroids, polyol, polyphenols, galangin, procyanidins, hydroxyl-α-sanshool, hydroxyl-β-sanshool, erythritol, ganomycin, caffeoylquinic acid, resin glycosides, saponins, avicularin, oleanolic acids, urasolic acid, ethanolic extracts etc., from various dietary and non-dietary naturally occurring sources.

show abstract

“…Fucoxanthin from extracts of edible brown seaweed Undaria pinnatifidae inhibits α-glucosidase activity through mixed type of inhibition ( Zaharudin et al, 2019 ).…”

Section: Dietary Sources and Their Bioactive α-Glucosidase Inhibitorsmentioning

confidence: 99%

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Hossain

Das

Ghosh

et al. 2020

Food and Chemical Toxicology

226

121

View full text Add to dashboard Cite

show abstract

“…Its activity is associated directly with levels of blood sugar . Various studies regard the inhibition of α ‐glucosidase and the screening of its inhibitors as new breakthroughs in the treatment of diabetes . Effective α ‐glucosidase inhibitors can block the enzyme in the small intestine to decompose the dietary complex carbohydrates and lower the levels of postprandial blood glucose.…”

Section: Introductionmentioning

confidence: 99%

“…3 Various studies regard the inhibition of -glucosidase and the screening of its inhibitors as new breakthroughs in the treatment of diabetes. 4 Effective -glucosidase inhibitors can block the enzyme in the small intestine to decompose the dietary complex carbohydrates and lower the levels of postprandial blood glucose. -Glucosidase inhibitors (AGIs) such as voglibose, acarbose, and miglitol are usually applied in clinical treatment of type-2 diabetes by retarding carbohydrates hydrolysis and reducing blood glucose levels.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of corosolic acid on α‐glucosidase: kinetics, interaction mechanism, and molecular simulation

Pan

et al. 2019

J Sci Food Agric

View full text Add to dashboard Cite

BACKGROUND The suppression of α‐glucosidase activity to retard glucose absorption is an important therapy for type‐2 diabetes. Corosolic acid (CRA) is a potential antidiabetic component in many plant‐based foods and herbs. In this study, the interplay mechanism between α‐glucosidase and corosolic acid was investigated by several methods, including three‐dimensional fluorescence spectra, circular dichroism spectra, and molecular simulation. RESULTS Corosolic acid significantly inhibited α‐glucosidase reversibly in an uncompetitive manner and its IC50 value was 1.35 × 10−5 mol L−1. A combination of CRA with myricetin exerted a weak synergy against α‐glucosidase. The intrinsic fluorescence of α‐glucosidase was quenched via a static quenching course and the binding constant was 3.47 × 103 L mol−1 at 298 K. The binding of CRA to α‐glucosidase was mainly driven by hydrophobic forces and resulted in a partial extension of the protein polypeptide chain with a loss of α‐helix content. The molecular simulation illustrated that CRA bound to the entrance part of the active center of α‐glucosidase and interacted with the amino acid residues Ser157, Arg442, Phe303, Arg315, Tyr158, and Gln353, which could hinder the release of substrate and catalytic reaction product, eventually suppressing the catalytic activity of α‐glucosidase. CONCLUSIONS These results may suggest new insights into corosolic acid from food sources as a potential α‐glucosidase inhibitor that could better control diabetes. © 2019 Society of Chemical Industry

show abstract

“…However, the AG quercetin-equivalent (QE) value of MU13 was almost 5-fold lower than the AG QE value of the benchmark. This postulate that the inhibitory activity might not derive from the flavonoid but complex non-starch polysaccharides from food hydrocolloid (Zaharudin et al 2019). The two initial samples displayed their AG inhibition for more than 80% inhibition.…”

Section: Discussionmentioning

confidence: 92%

Antioxidant and Anti-Diabetic Status of Popular Malay Health Tonic Consumed for Wellness: Help or Hype?

Zayapor¹,

Abdullah²,

Mustapha³

2020

JSM

View full text Add to dashboard Cite

Contemporary Malay health tonics labeled as botanical drinks are advertised in the Malaysian market as effective therapeutic supplements toward improving consumer health. The therapeutic claims associated with high antioxidants are based on the herbal ingredients used, yet unproven by scientific evidence. Moreover, they are mostly sweetened with sugar, which may arise the potential of diabetic risk. Thus, a dire clarification on the potential antioxidant status and diabetic risk of these products is essential to nullify over claims. Eight commercial botanical drinks that serve as health tonics were selected based on their advertisement popularity and traditional medicine sellers' interview feedbacks. The selected tonics were mutually compared with a green tea (DGT01) as the benchmark for their total phenolic content (TPC); antioxidant activities [the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging inhibition capacities, IC 50 ; Ferric ion reducing antioxidant power (FRAP); and Oxygen radical absorbance capacity (ORAC)], anti-diabetic property through the α-glucosidase inhibition (AGI) and as well as the sugar content. The results were mapped for variations using Principal Component Analysis (PCA). Three out of 8 health tonics (NS12, SK53, and MU13) has approximately 3 to 4-fold, 1.1-fold and 2.5-fold higher in TPC, ORAC, and FRAP reducing capacities, respectively. Only NS12 and SK53 showed strong AGI (>80% inhibition). Three tonics, NS12, SK53, and HS06 exhibited precaution levels of sugar with more than 180 mg of total sugars per serving. From the PCA, DGT01 was dissociated from any tonic. NS12 and SK23 were closely related in terms of antioxidant and AGI activities. Although they showed promising therapeutic benefits due to high antioxidant activities and low diabetic risk, the tonics' efficacies and safety are still dubious shall be verified by reliable clinical trials. The selection of a health tonic shall not only be based on multi antioxidant-rich ingredients but low in sugar for a healthier choice.

show abstract

Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin

Cited by 76 publications

References 28 publications

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Inhibitory effect of corosolic acid on α‐glucosidase: kinetics, interaction mechanism, and molecular simulation

Antioxidant and Anti-Diabetic Status of Popular Malay Health Tonic Consumed for Wellness: Help or Hype?

Contact Info

Product

Resources

About