Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout

Kong, Ling-Dong; Cai, Yu; Huang, W.; Chen, Cheng; Tan, Ren Xiang

doi:10.1016/s0378-8741(00)00305-6

Cited by 221 publications

(141 citation statements)

References 12 publications

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“…Dried chrysanthemum flowers are used as a traditional remedy for gout in China [9]. Several constituents of the flowers exhibit antiinflammatory activity, including triterpene alcohol [10,11], octulosonic acid derivatives [12], and flavonoids [13].…”

Section: Backgroundsmentioning

confidence: 99%

Luteolin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia

Hirano¹,

Takeda²,

Hitoe³

et al. 2017

Integr Mol Med

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Background: Luteolin is a flavonoid found in various edible plants that exhibits diverse health benefits, including anti-inflammatory and anti-gout effects. However, there has been little clinical investigation of luteolin from the viewpoint of gout prevention. We conducted a clinical trial of supplementation with chrysanthemum flower extract rich in luteolin (LCE) to assess the effect on serum uric acid levels in Japanese men.

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Section: Backgroundsmentioning

confidence: 99%

Luteolin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia

Hirano¹,

Takeda²,

Hitoe³

et al. 2017

Integr Mol Med

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“…Moreover, AChE inhibitors are most active in the treatment of a variety of diseases, including Alzheimer's disease, Parkinson's disease, ataxia and senile dementia. XO catalyses the oxidation of xanthine and hypoxanthine into uric acid, which may lead to a disease known as gout (Kong et al, 2000). Some drugs and plant-derived extracts which serve as XO inhibitors may block uric acid biosynthesis, lower the plasma uric acid concentration and are used to treat gout (Nguyen et al, 2004).…”

Section: Enzyme Inhibition Activitymentioning

confidence: 99%

Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

Mongalo

McGaw

Finnie

et al. 2015

Journal of Ethnopharmacology

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Ethnopharmacologicalrelevance: Securidaca longipedunculata Fresen (Polygalaceae) is a multi-purpose plant with a long history of use in African traditional medicine to treat various sexually transmitted infections, hernias, coughs, fever, ascariasis, constipation, headaches, rheumatism, stomach ache, malaria, tuberculosis, pain, epilepsy, pneumonia, skin infections, and it is also used as an aphrodisiac for men. The current paper provides an overview of the present phytochemistry, toxicology, ethnomedicinal uses and pharmacological properties of S. longipedunculata. Materials and methods:The information reported in this paper was collected from a literature search using various computerised databases including ScienceDirect, Moreover, the pharmacokinetic properties of extracts and compounds of the species need to be explored as there is insufficient data available on these aspects.

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“…To find such inhibitor, botanical sources were relentlessly investigated to fish out any clinically applicable XO inhibitors (Kong et al, 2000;Sweeney et al, 2001;Zhu et al, 2004;Zhao et al, 2006;Wang et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities ofHyoscyamus reticulatus

Mohammad¹,

Almasri²,

Tawaha³

et al. 2010

Pharmaceutical Biology

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Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout

Cited by 221 publications

References 12 publications

Luteolin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia

Luteolin-rich chrysanthemum flower extract suppresses baseline serum uric acid in Japanese subjects with mild hyperuricemia

Securidaca longipedunculata Fresen (Polygalaceae): A review of its ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology

Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities ofHyoscyamus reticulatus

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