Inhibition of USP21 leads to ovarian carcinoma cell death by suppressing MAPK signaling
Xin Sun,
Jia Yu,
Xiaorong Cui
et al.
Abstract:Ovarian cancer is the most aggressive and lethal of all gynecologic malignancies. Although the overexpression (OE) of ubiquitin‐specific peptidase 21 (USP21) has been observed in multiple cancers, its expression profile and biological function in ovarian cancer remain unknown. The expression levels of USP21 in ovarian cancer cells and tissues as well as adjacent normal tissues were assessed by qRT‐PCR or Western blot assay. The biological function of USP21 in ovarian cancer cells was assessed by cell growth as… Show more
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