The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer

Shi, Zhen-Yuan; Li, Chang-Yun; Chen, Ru-Yi; Shi, Jin-Jin; Liu, Yan-Jun; Lu, Jian-Fei; Yang, Guan-Jun; Chen, Jiong

doi:10.1016/j.bioorg.2024.107400

Cited by 2 publications

(1 citation statement)

References 98 publications

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“…DUBs are associated with physiological and pathological processes that modulate various cellular processes. The repertoire of human DUBs encompasses approximately 100 enzymes that are categorized into seven distinct families: ubiquitin-specific proteases (USP/UBP), ubiquitin C-terminal hydrolases (UCHs), ovarian tumor proteases (OTUs), JAB1/MPN/MOV34s (JAMMs), josephins, zinc finger proteins containing UFM1-specific peptidase domains such as ZUFSP, and the recently characterized MINDY protease [1][2][3]. The USP family, composed of more than 50 members, represents the most extensive and heterogeneous subset within the DUB family [4,5].…”

Section: Introductionmentioning

confidence: 99%

The Emerging Role of Ubiquitin-Specific Protease 36 (USP36) in Cancer and Beyond

Niu,

Liu,

Shi

et al. 2024

Biomolecules

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The balance between ubiquitination and deubiquitination is instrumental in the regulation of protein stability and maintenance of cellular homeostasis. The deubiquitinating enzyme, ubiquitin-specific protease 36 (USP36), a member of the USP family, plays a crucial role in this dynamic equilibrium by hydrolyzing and removing ubiquitin chains from target proteins and facilitating their proteasome-dependent degradation. The multifaceted functions of USP36 have been implicated in various disease processes, including cancer, infections, and inflammation, via the modulation of numerous cellular events, including gene transcription regulation, cell cycle regulation, immune responses, signal transduction, tumor growth, and inflammatory processes. The objective of this review is to provide a comprehensive summary of the current state of research on the roles of USP36 in different pathological conditions. By synthesizing the findings from previous studies, we have aimed to increase our understanding of the mechanisms underlying these diseases and identify potential therapeutic targets for their treatment.

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Section: Introductionmentioning

confidence: 99%

The Emerging Role of Ubiquitin-Specific Protease 36 (USP36) in Cancer and Beyond

Niu,

Liu,

Shi

et al. 2024

Biomolecules

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Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment

Li,

Yuan,

et al. 2024

Front. Immunol.

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Lung cancer (LC) is one of the most common cancer worldwide. Tumor-associated macrophages (TAMs) are important component of the tumor microenvironment (TME) and are closely related to the stages of tumor occurrence, development, and metastasis. Macrophages are plastic and can differentiate into different phenotypes and functions under the influence of different signaling pathways in TME. The classically activated (M1-like) and alternatively activated (M2-like) represent the two polarization states of macrophages. M1 macrophages exhibit anti-tumor functions, while M2 macrophages are considered to support tumor cell survival and metastasis. Macrophage polarization involves complex signaling pathways, and blocking or regulating these signaling pathways to enhance macrophages’ anti-tumor effects has become a research hotspot in recent years. At the same time, there have been new discoveries regarding the modulation of TAMs towards an anti-tumor phenotype by synthetic and natural drug components. Nanotechnology can better achieve combination therapy and targeted delivery of drugs, maximizing the efficacy of the drugs while minimizing side effects. Up to now, nanomedicines targeting the delivery of various active substances for reprogramming TAMs have made significant progress. In this review, we primarily provided a comprehensive overview of the signaling crosstalk between TAMs and various cells in the LC microenvironment. Additionally, the latest advancements in novel drugs and nano-based drug delivery systems (NDDSs) that target macrophages were also reviewed. Finally, we discussed the prospects of macrophages as therapeutic targets and the barriers to clinical translation.

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The emerging role of deubiquitylating enzyme USP21 as a potential therapeutic target in cancer

Cited by 2 publications

References 98 publications

The Emerging Role of Ubiquitin-Specific Protease 36 (USP36) in Cancer and Beyond

The Emerging Role of Ubiquitin-Specific Protease 36 (USP36) in Cancer and Beyond

Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment

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