Inhibition of tumor growth and angiogenesis by water extract of Gac fruit (Momordica cochinchinensis Spreng)

Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid

“…In further studies, the biochemical and molecular analyses will be performed to explain additional mechanisms of how the MC could prevent such adverse effects. The protective tissue damage effect demonstrated in this study is a phytotherapeutic property of MC extract besides other pharmacological properties shown in previous reports (Zheng et al;Jung et al, 2013aJung et al, , 2013bLiu et al;Chuethong et al;Tien et al;Kang et al;Tsoi et al;Xiao et al, 2007Xiao et al, , 2009Rajput et al, 2007Rajput et al, , 2010. Moreover, MC extract indeed did not affect any male reproductive parameters including testicular histology as compared to the control.…”

“…Recently, various scientific studies have shown that MC fruit extract has antioxidant and pharmacological properties (Kubola & Siriamornpun, 2011). MC has been demonstrated to have anti-cancer activities (Zheng et al, 2014;Jung et al, 2013a;Liu et al, 2012;Chuethong et al, 2007;Tien et al, 2005). In addition, it was also reported for its anti-inflammatory effect (Jung et al, 2013b) and angiogenesis (Kang et al, 2010).…”

Gac fruit (Momordica cochinchinensis Spreng.): a rich source of bioactive compounds and its potential health benefits

“…The antitumour activity of a water extract from the whole green Gac fruit was investigated by the treatment of Balb/c mice transplanted with the colon 26-20 adenocarcinoma and HepG2 cell lines (Tien et al, 2005). The results showed that the extract led to a significant decrease in the proliferation of colon 26-20 and HepG2 cells and a reduction of tumour weight in the treated mice.…”

Process development of Gac powder by using different enzymes and drying techniques

“…Researchers have been investigated the potential of these two carotenoids to prevent and treat cancers and vitamin A deficiency. Juice extracted from dried Gac could reduce the tumour weights in mice by 23.6% (Tien et al, 2005). In an experiment (Kucuk et al, 2002), newly diagnosed prostate cancer patients were supplied with 30 mg of tomato lycopene extract daily within 3 weeks.…”