Momordica cochinchinensis (L.) Spreng: Aril Extract Prevents Adverse Reproductive Parameters of Male Rats Induced with Valproic Acid

Antioxidant Capacity of Momordica charantia Extract and its Protective Effect on Testicular Damage in Valproic Acid-Induced Rats

“…Indeed, it has been reported to have adverse effects such as decreasing of sex hormones and sperm qualities (Nishimura et al, 2000;Herzog et al, 2004;Hamza & Amin, 2007;Khan et al, 2011;Iamsaard et al, 2017a,b;Sukhorum & Iamsaard, 2017). Currently, herbal medicines have been studied for searching of alternative VPA treatments (Sakr et al, 2014;Iamsaard et al, 2015Iamsaard et al, , 2017bSukhorum et al, 2016). activity (Ghous et al, 2015), antidiabetic property (Blum et al, 2012), and anticancer property (Lee-Huang et al, 1995).…”

Protective Effect of Momordica cochinchinensis (L.) Spreng Aril Extract on Essential Testicular Markers in Rats Induced with Valproic Acid

“…MC collection and extraction were described in our previous report (Sukhorum et al, 2016). In addition, the antioxidant capacity were already tested such as total phenolic compound, total flavonoid content, DPPH free radical scavenging, and ferric reducing antioxidant power of this extract by Assist.…”

“…Rats were divided into 6 groups (n = 8); control (DW), VPA (500 mg kg-1), MC200 (200 mg kg-1), MC50+VPA (50 mg kg-1), MC100+VPA (100 mg kg-1) and MC200+VPA groups. The experiment periods (divided into two sub-periods: a protective period [days 1-23] and a co-administrative period [days 24-33]) of this study were totally 33 days as followed previous study of our group (Sukhorum et al, 2016). At the end of experiment (day 34), all rats were euthanized with i. p. injecting of concentrated pentobabital sodium.…”

“…However, VPA has been reported to exert side effects on reproductive systems of epileptic patients and animal models including decreases of the FSH, LH and testosterone levels, male reproductive parameters and sperm motility, and various histopathological changes suggesting testicular atrophy (Isojärvi, 2008;Hamza & Amin, 2007;Iamsaard et al, 2015;Sukhorum et al, 2016;Sukhorum & Iamsaard, 2017). Moreover, VPA has been shown to increase the malondialdehyde levels in serum and tissue whereas it decreases the activity of antioxidant enzymes in the testis (Hamza & Amin;Sakr et al, 2014).…”

“…Moreover, VPA has been shown to increase the malondialdehyde levels in serum and tissue whereas it decreases the activity of antioxidant enzymes in the testis (Hamza & Amin;Sakr et al, 2014). In addition, some information about the molecular mechanism underlying the effects of VPA on the male reproductive system, especially effects on spermatogenesis and sex hormone production including testicular Ki-67, phosphorylated proteins, steroidogenic acute regulatory protein (StAR), and cholesterol side-chain cleavage enzyme (P450scc) has been published by our group (Sukhorum et al, 2016). Currently, many medicinal plants have been used in searching for alternative treatments to prevent such side effects of VPA administration (Hamza & Amin; Sakr et al; Iamsaard et al).…”