Inhibition of thermolysin and human α-thrombin by cobalt(III) Schiff base complexes

Takeuchi, Toshihiko; Böttcher, Arnd; Quezada, C.M.; Meade, Thomas J.; Gray, Harry B.

doi:10.1016/s0968-0896(98)00272-7

Cited by 99 publications

(100 citation statements)

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“…The affinity of the coordinated zinc for the histidine and cysteine residues has been used to generate transition metal inhibitors of enzymatic activity and DNA-protein interaction (21)(22)(23)(24). Displacement of the zinc ion by a Co(III) Schiff base complex [Co(III)-sb] has been shown to inhibit DNA binding of at least 1 other zinc finger transcription factor (25) and enzymatic function of non-DNA binding proteins (25)(26)(27)(28).…”

mentioning

confidence: 99%

“…The mechanism involves dissociative ligand exchange where the substitutionally active axial ammines are displaced by water to form the di-aquo species (28). The lone pair of electrons on the nitrogenous donors of the imidazole ring of histidines present in a zinc finger coordinate to the Co(III) agent irreversibly disrupting the coordination environment of Zn(II) (25,27).…”

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confidence: 99%

“…The ligand exchange is on the axial ligands, because a Co(III)-sb with substitutionally labile 2-methyl imidazole axial ligands irreversibly interacts with a model zinc finger peptide whereas a substitutionally inert Co(III)-sb with imidizole axial ligands does not (27). This is an irreversible reaction, and inhibition of DNA binding is concentration dependent.…”

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confidence: 99%

“…In the absence of a targeting moiety, such as an oligonucleotide, we have reported that multiple cobalt complexes can interact with a single protein, although only 1 is required for complete inhibition of function (25,27,28). To examine the effectiveness of targeting, the minimal concentration at which Co(III)-sb inhibits Slug DNA binding was determined.…”

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Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate

Harney

Lee²,

Manus³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate

Harney

Lee²,

Manus³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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“…is an essential element widely distributed in biological system [6,[17][18]. Numerous cobalt complexes has been studied as hydrolytic agent for DNA cleavage [19-20], antitumor, antproli-ferative[21-23], antimicrobial[24-26] and antifungal [21,27], antiviral [28,29], antioxidant [12 ,30] and ant inflammatory activity [30]. They have exhibited antitumorogenic activity by reducing the number and size of carcinogen induced colon tumors and play synergistic role on the activity of certain antitumor drugs, although the mechanism has not been completely clarified [31][32][33].…”

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confidence: 99%

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Tak¹

2017

IJRASET

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Novel complexes of copper (II), cobalt (II) and nickel (II) with sulphapyridine and aminothiazole were synthesized and characterized using spectral and analytical techniques. The interaction of cobalt (II) complexes with herring sperm DNA has been performed using absorption titration, viscometric measurements and cyclic voltammetry. The protective activity of metal complexes has been carried out using arose gel electrophoresis. The results indicate that cobalt (II) complex bind to DNA via electrostatic or groove binding with binding constant K b = 4.5 x 10 4 M -1. The antioxidant activity for cobalt (II) complex was also checked. Keywords: hypochromism, peak potential and binding constant. I. INTRODUCTIONThe binding of metal complexes to DNA has been extensively studied over the past decade. Many coordination compounds are able to bind DNA as structural probes[1], DNA foot printing [2], DNA cleaving agents [3][4] and as potential anticancer drugs [5][6]. It is generally believed that many anticancer, antiviral, and antiseptic agents take action through binding DNA [4,[7][8], since the interaction between small molecules and DNA can often cause DNA damage in cancer cells, blocking the division of cancer cells and resulting in cell death [9][10][11]. Many studies indicate that transition metal complexes can bind to DNA via both covalent (replacement of labile coordinating ligand by nitrogen base of DNA (i.e. adenine, Cytosine, guanine, thymine) and or non covalent interaction (intercalation, electrostatic or groove binding) [12]. Many important applications of these complexes require that they can bind via intercalative mode or groove binding [13]. Therefore interaction of complexes especially with planar aromatic heterocyclic ligands, which can insert into the base pairs of DNA duplex has attracted considerable attention [14][15][16]. is an essential element widely distributed in biological system [6,[17][18]. Numerous cobalt complexes has been studied as hydrolytic agent for DNA cleavage [19-20], antitumor, antproli-ferative[21-23], antimicrobial[24-26] and antifungal [21,27], antiviral [28,29], antioxidant [12 ,30] and ant inflammatory activity [30]. They have exhibited antitumorogenic activity by reducing the number and size of carcinogen induced colon tumors and play synergistic role on the activity of certain antitumor drugs, although the mechanism has not been completely clarified [31][32][33]. Ligands having nitrogen donors received considerable attention because of their mixed hard-soft donor character, versatile coordination behavior [34][35] and for their biological activity (i.e., toxicity against bacterial growth [36], anticancer [37] and other biochemical properties [38]). The coordination geometry and nature of donor atoms play key roles in determining the binding extent of complexes to DNA. The importance of central metal ion at the core of the structure is noteworthy [39,40]. Many DNA heterocyclic compounds such as benzothiazole and benzopyra zine derivatives have been evaluated and f...

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Metals in Medicine: Therapeutic Agents

Mukherjee¹,

Sadler²

2009

Wiley Encyclopedia of Chemical Biology

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Within the emerging field of medicinal inorganic chemistry, the realization that metal complexes can be designed as both therapeutic and diagnostic agents with novel mechanisms of action is increasing. Some recent advances are highlighted in this review, beginning with the success of platinum anticancer complexes and attempts to extend such activity to other transition metals, even to arsenic. Lithium is widely used for bipolar affective disorders, and gold is used for the treatment of rheumatoid arthritis. Metal ions also play crucial roles in contrast agents for magnetic resonance imaging and in radiopharmaceuticals used for imaging and therapy. Metal complexes offer flexible design platforms as enzyme inhibitors, and metals in enzyme active sites can be key drug targets. The antimicrobial and antiviral activities of certain metal complexes may prove useful in the fight against antibiotic resistance. Metals play key roles, too, in the control of small signaling molecules such as nitric oxide and carbon monoxide. Control of the uptake and distribution of the essential metals also presents a challenge, which is aided by modern genomic knowledge.

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Inhibition of thermolysin and human α-thrombin by cobalt(III) Schiff base complexes

Cited by 99 publications

References 28 publications

Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate

Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Metals in Medicine: Therapeutic Agents

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