Inhibition of the Transsulfuration Pathway Affects Growth and Feather Follicle Development in Meat-Type Chickens

Silva, José Humberto Vilar Da; González-Cerón, Fernando; Howerth, Elizabeth W.; Rekaya, Romdhane; Aggrey, Samuel E.

doi:10.1080/10495398.2018.1461634

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…This was presumably a transcriptionally regulated means to overcome reduced transsulfuration flux. Other researchers have observed increased CBS and CSE mRNA expression when chicks were exposed to specific chemical inhibitors of CSE [ 77 ]. Therefore, chickens (independent of age) attempt to overcome transsulfuration perturbations via the transcriptional upregulation of CBS and CSE.…”

Section: Discussionmentioning

confidence: 99%

Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon Metabolism

Weston

Hales

2021

Molecules

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We used an LC-MS/MS metabolomics approach to investigate one-carbon metabolism in the plasma of flaxseed-fed White Leghorn laying hens (aged 3.5 years). In our study, dietary flaxseed (via the activity of a vitamin B6 antagonist known as “1-amino d-proline”) induced at least 15-fold elevated plasma cystathionine. Surprisingly, plasma homocysteine (Hcy) was stable in flaxseed-fed hens despite such highly elevated cystathionine. To explain stable Hcy, our data suggest accelerated Hcy remethylation via BHMT and MS-B12. Also supporting accelerated Hcy remethylation, we observed elevated S-adenosylmethionine (SAM), an elevated SAM:SAH ratio, and elevated methylthioadenosine (MTA), in flaxseed-fed hens. These results suggest that flaxseed increases SAM biosynthesis and possibly increases polyamine biosynthesis. The following endpoint phenotypes were observed in hens consuming flaxseed: decreased physiological aging, increased empirical lifespan, 9–14% reduced body mass, and improved liver function. Overall, we suggest that flaxseed can protect women from ovarian tumor metastasis by decreasing omental adiposity. We also propose that flaxseed protects cancer patients from cancer-associated cachexia by enhancing liver function.

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Section: Discussionmentioning

confidence: 99%

Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon Metabolism

Weston

Hales

2021

Molecules

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“…LOC101798015, also known as CBS, encodes cystathionine beta synthase. This enzyme can affect feather follicle development in chickens (Humberto Vilar Da Silva et al, 2019;FIGURE 4 Four top SNPs within the intron of the gene STARD9 within a haplotype block. Linkage disequilibrium and haplotype block of the gene STARD9 was estimated using Haploview 4.1 software (Barrett et al, 2005) based on confidence intervals (Gabriel et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study for the primary feather color trait in a native Chinese duck

Sun

Wu²,

Lin³

et al. 2023

Front. Genet.

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Background: To reveal candidate genes and the molecular genetic mechanism underlying primary feather color trait in ducks, a genome-wide association study (GWAS) for the primary feather color trait was performed based on the genotyping-by-sequencing (GBS) technology for a native Chinese female duck, Longyan Shan-ma ducks.Methods: Blood genomic DNA from 314 female Longyan Shan-ma duck were genotyped using GBS technology. A GWAS for the primary feather color trait with genome variations was performed using an univariate linear mixed model based on all SNPs in autosomes.Results: Seven genome-wide significant single nucleotide polymorphisms (SNPs, Bonferroni-adjusted p-value <8.03 × 10−7) within the introns of the genes STARD9, ZNF106, SLC7A5, and BANP genes were associated with the primary feather color trait. Twenty-two genome-wide suggestive SNPs (Bonferroni-adjusted p-value <1.61 × 10−5) of 17 genes (besides ZNF106 and SLC7A5) were also identified. Seven SNPs were located at one 0.22 Mb region (38.65–38.87 Mb) on chromosome 5, and six SNPs were located at one 0.31 Mb region (19.53–19.84 Mb) on chromosome 11. The functions of STARD9, SLC7A5, BANP, LOC101798015, and IPMK were involved pigmentation and follicle development, especially, STARD9 upregulated expression in black feather (haplotype-CCCC) bulb tissue compared with in pockmarked feather (haplotype-TGTT) bulb tissue, implicating these genes as candidate genes for primary feather color trait.Conclusion: The preliminarily findings suggested candidate genes and regions, and the genetic basis of primary feather color trait in a female duck.

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“…Cysteine is also the main component of keratinized proteins in feathers, and in birds, the demand for cysteine is fulfilled via the transsulfuration pathway. Inhibition of the transsulfuration pathway can affect hair follicle development, skin thickness, and growth in broilers; moreover, this inhibition is associated with the upregulation of hepatic cystathionine synthase and cystathionine lyase mRNAs (Silva et al, 2018). Silva et al (2019) randomized chicks into control and cysteine-deficient groups for 49 days and measured their skin layer thickness and hair follicle length and thickness on days 10, 24, 34, and 49 after treatment, respectively.…”

Section: Introductionmentioning

confidence: 99%

Role of Sulfur Metabolism Gene and High-Sulfur Gene Expression in Wool Growth Regulation in the Cashmere Goat

Chai

Sun

Liu³

et al. 2021

Front. Genet.

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Sulfur, an essential mineral element for animals, mainly exists in the form of organic sulfur-containing amino acids (SAAs), such as cystine, methionine, and cysteine, within the body. The content, form, and structure of sulfur play an important role in determining the wool fiber quality. In addition, keratin-associated proteins, one of the most crucial wool fiber components, are rich in SAAs. However, sulfur metabolism from the blood to the skin and hair follicles remains unclear. In this study, we analyzed high-sulfur protein gene and sulfur metabolism genes in the cashmere goat and explored the effects of melatonin on their expression. In total, 53 high-sulfur protein genes and 321 sulfur metabolism genes were identified. We found that high-sulfur protein genes were distributed in the 3–4 and 144M regions of chromosome 1 and the 40–41M region of chromosome 19 in goats. Moreover, all year round, allele-specific expression (ASE) is higher in the 40–41M region of chromosome 19 than in the other regions. Total of 47 high-sulfur protein genes showed interaction with transcription factors and cofactors with ASE. These transcription factors and cofactors were inhibited after melatonin implantation. The network analysis revealed that melatonin may activate the sulfur metabolism process via the regulation of the genes related to cell energy metabolism and cell cycle in the skin, which provided sufficient SAAs for wool and cashmere growth. In conclusion, our findings provide a new insight into wool growth regulation by sulfur metabolism genes and high-sulfur protein genes in cashmere goats.

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Inhibition of the Transsulfuration Pathway Affects Growth and Feather Follicle Development in Meat-Type Chickens

Cited by 6 publications

References 15 publications

Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon Metabolism

Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon Metabolism

Genome-wide association study for the primary feather color trait in a native Chinese duck

Role of Sulfur Metabolism Gene and High-Sulfur Gene Expression in Wool Growth Regulation in the Cashmere Goat

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