Inhibition of the target phenomenon in tenotomized rabbit muscle by medullary lesions

Reuck, Jacques De; Coster, W. De; Potter, Robert De; Eecken, H. vander

doi:10.1007/bf00690584

Acta Neuropathol

1982

DOI: 10.1007/bf00690584

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Inhibition of the target phenomenon in tenotomized rabbit muscle by medullary lesions

Jacques De Reuck¹,

W. De Coster²,

Robert De Potter³

et al.

Abstract: Target fibres were demonstrated in the gastrocnemius muscles following section of the Achilles tendon of two rabbits. In five other animals with tenotomized gastrocnemius muscles, a subarachnoid phenol block of the lumbar and sacral spinal cord was performed. Large and small medullary lesions inhibited the occurrence of target fibres in the tenotomized muscles, the smallest one being neurolysis of the dorsal roots. This final experiment suggests that the target phenomenon is the morphological expression of an … Show more

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1983

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Cited by 4 publications

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Modifications in the histochemical and biochemical changes in tenotomized rat soleus by denervation

Talesara

Jasra

1986

Pflugers Arch.

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Response of tenotomized rat soleus muscle to denervation performed at different time intervals, has been investigated. Tenotomized muscles showed typical central core lesions seven days post-operatively. These were not observed in m-ATPase stained sections of simultaneously denervated and tenotomized muscles, and muscles denervated 24 h after tenotomy. Central core lesions were not prevented in muscles denervated 28 h after tenotomy, indicating that tenotomy effects responsible for central lesions are completed by this time. Myosin light chain pattern of muscles denervated 28 h after tenotomy, and tenotomized only were similar showing increased LC3/LC1 ratio. Simultaneously denervated and tenotomized muscle however showed all the three light chains relatively equal in quantity. The results suggest that elimination of neural activation within 28 h prevents myofibrillar loss and minimized other changes which occur due to tenotomy.

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Modifications in the histochemical and biochemical changes in tenotomized rat soleus by denervation

Talesara

Jasra

1986

Pflugers Arch.

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Influence of stretch on the target phenomenon in the tenotomized and immobilized gastrocnemius muscle of the rat

Reuck¹,

Coster²,

Eecken³

1983

Acta Neuropathol

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The influence of traction on the target phenomenon was analysed in the tenotomized gastrocnemius muscle of Wistar rats. Target fibres were constantly observed at the medial side of the heads of the non-immobilized and tenotomized gastrocnemius muscles used as control. In the muscles fixed in flexion, no target fibres could be detected, while in the muscles fixed in hyperextension some target fibres were seen. The latter were less numerous than those present in the non-immobilized muscles. This experiment proves the importance of stretch mechanisms in the pathogenesis of the target phenomenon.

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Influence of isaxonine on reinnervation of the rat gastrocnemius muscle

Reuck¹,

Bleecker²,

Coster³

et al. 1987

Acta Neuropathol

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Isaxonine is reported to have a favourable effect on nerve regeneration. The histological and histochemical changes were compared in the gastrocnemius muscles of 20 rats, in which the left sciatic nerve was frozen-crushed for 10 s at the level of the buttock. The animals received a daily dose of intraperitoneal isaxonine and ten others the solvent only. After 8 weeks small type grouping was seen in rats receiving solvent only and large type grouping in rats treated with isaxonine. After 10 weeks a checkerboard pattern of the fibre types was observed in the muscles of animals receiving solvent only but fibre type grouping was present in those treated with isaxonine. This experiment indicates that isaxonine prevents synaptic remodelling by suppression of the redundant nerve endings from additional axons, which have regenerated more slowly, in making contact with motor endplates.

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Inhibition of the target phenomenon in tenotomized rabbit muscle by medullary lesions

Cited by 4 publications

References 11 publications

Modifications in the histochemical and biochemical changes in tenotomized rat soleus by denervation

Modifications in the histochemical and biochemical changes in tenotomized rat soleus by denervation

Influence of stretch on the target phenomenon in the tenotomized and immobilized gastrocnemius muscle of the rat

Influence of isaxonine on reinnervation of the rat gastrocnemius muscle

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