Inhibition of the pro-inflammatory mediators’ production and anti-inflammatory effect of the iridoid scrovalentinoside

Medicinal herbs for the treatment of rheumatic disorders—A survey of European herbals from the 16th and 17th century

“…The production of the pro-inflammatory cytokines, PGE 2 , LTB 4 and NO was reduced. Scrovalentinoside inhibited the expression von iNOS, but did not influence levels of already available NO (Bas et al, 2007). Seven iridoid glycosides were isolated from Scrophularia scorodonia and identified as bartioside, aucubin, harpagid, harpagoside, 8-acetylharpagosid, scorodioside and scropolioside B.…”

Characterization, anti-oxidative and anti-inflammatory effects of Costa Rican noni juice (Morinda citrifolia L.)

“…In the other hand, the number of publications on anti-inflammatory activity of iridoids has increased significantly in recent years. For instance, lamiide (Delaporte et al, 2002), ipolamiide (Schapoval et al, 1998), genipin (Koo et al, 2004), scrovalentinoside (Bas et al, 2007), and hydrolyzed aucubin (Park and Chang, 2004) have been described for theirs anti-inflammatory activities in various models.…”

Inhibition of Pro-inflammatory Cytokines by Ethyl Acetate Extract of <i>Scrophularia striata</i>

“…Moreover, the anti-inflammatory activity of some species in this genus such as Scrophularia scorodonia has shown showed [6,7]. The inhibition of pro-inflammatory cytokines of ethyl acetate extract of S. striata may be ascribed to natural compounds such as flavonoids in this extract of plant that has potential anti-inflammatory effect for inhibition of pro-inflammatory mediators by LPS activated macrophages.…”

“…We have previously demonstrated the inhibitory effect of S. striata extract on nitric oxide production in vitro and ex vivo model [5]. Many Scrophularia species have been investigated and several compounds from different classes of secondary metabolites including iridoids, phenyl propanoids, phenolic acids, flavonoids, quercetin, isorhamnetin 3-Orutinoside and saponins by column chromatography have been isolated [6][7][8]. In the present study, we investigated the effect of ethyl acetate extract of S. striata on the inhibition of pro-inflammatory cytokines (IL-1β, TNF-α, and PGE2) by LPS-activated macrophages.…”