Inhibition of the Phagocytic Action of Leucocytes by Mumps and Influenza Viruses

Abstract

320 0 1 ' I I I 3 ? 14 23 31 OAYS AFTER INlECnONS F I G . 3. Potentiation of a commercial aqueous testosteroae suspension by aluminum phosphate. Seminal vesicle response of immature rats to a single intramuscular injection.slower release from the depot site, it follows that a depot of micro-crystalline testosterone, subcutaneously or intramuscularly, should be ideal for slow absorption. As yet, there is no experimental demonstration of the mechanism by which aqueous A1P04 suspmsion of testosterone elicits a greater androgenic respmse than the aqueous suspensions without Alp&.Summary. The experimental data confirm the depot effect described by Carlinfanti and his co-workers following subcutaneous injection of ATAP suspensions in the guinea pig.The effect also has been demonstrated in immature castrate rats after intramuscular injection. In both instances marked increase in response and duration of biological activity were obtained. Potency ratios and indices of duration of action indicate that each milligram of testosterone in aqueous aluminum phosphate suspension is ( 1 ) two or more times as active, and (2) acts approximately two to three times as long as the same quantity of testosterone in aqueous suspension alone.

Inhibition of the Phagocytic Activity of Leukocytes by Coxsackie Viruses

“…Thermic inactivation of Coxsackie viruses was found to de prive them of their ability to inhibit the phagocytic activity of leukocytes. Similar results were obtained with inactivated influ enza and mumps viruses (13). On the other hand, thermic inactiv ation of bacteriophages (10) and of vaccinia virus (14) did not suppress their action on leukocytes.…”

“…It was observed that in experiments which resulted in complete inhibition the cells shrank to half their original diam eter, the structure of the nuclei became denser and they stained more intensly. It is noteworthy that similar morphological changes were reported by Merchant and Morgan (13) as well as by Kan toch, Skurski and Wieczorek (10). Merchant and Morgan found that influenza and mumps viruses decreased the phagocytic activ ity for bacteria by 20-30 per cent and simultaneously diminished the diameter of leukocytes.…”

“…In recent years it has been found that viruses combining with neutrophyiic leukocytes bring about a decrease in their phago cytic activity (3,10,13). The present paper deals with the results of studies on the inhibition of the phagocytic activity of leuko cytes by Coxsackie viruses.…”

The effect of Sendai virus infection on bactericidal and transport mechanisms of the murine lung

“…The inhibitory effect on the antibacterial activity of phagocytic cells by virus infection has been described earlier (7,19). These in vitro studies suggest a direct antiphagocytic action of the virus on the leukocytes; however, the nature of the in vivo effects of virus infection on alveolar macrophages remain to be conclusively demonstrated.…”

Inhibition of the Phagocytic Activity of Leukocytes by Coxsackie Viruses

“…Coxsackie virus, like other viruses, possesses the ability to inhibit the phagocytic activity of leukocytes (5,8,9,12). The degree of inhibition depends on the concentration of the viral pre paration used and on the duration of its action on the leukocytic cells.…”