Inhibition of the human primary motor area by painful heat stimulation of the skin

Valeriani, Massimiliano; Restuccia, Domenico; Lazzaro, Vincenzo Di; Oliviero, Antonio; Profice, Paolo; Pera, Domenica Le; Saturno, E.; Tonali, P.

doi:10.1016/s1388-2457(99)00075-9

Cited by 112 publications

(77 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is known that pain affects motor output in a variety of ways, ranging from changes in reflex activation to central inhibition to drive the muscle maximally. [35][36][37] We have also shown that experimentally induced knee pain via injection of hypertonic saline into the infrapatellar fat pad in healthy individuals can lead to alterations in vasti control during stair stepping, which are reversed when pain subsides (unpublished data). Thus, pain is a potent driver of changes in neuromotor control.…”

Section: Effect Of Patellar Tapingmentioning

confidence: 86%

Effect of patellar taping on vasti onset timing, knee kinematics, and kinetics in asymptomatic individuals with a delayed onset of vastus medialis oblique

2006

View full text Add to dashboard Cite

This randomized within-subject study investigated the effects of patellar tape on the onset of electromyographic (EMG) activity of vastus medialis obliquus (VMO) relative to vastus lateralis (VL), knee kinematics, and kinetics in 12 currently asymptomatic individuals with a VMO timing deficit and a history of patellofemoral pain. Participants were required to complete stair stepping and normal-pace and fast-pace walking tasks under three experimental conditions; no tape, control tape and therapeutic tape. EMG onsets of VMO and VL were measured by surface electrodes, stance phase knee flexion by the PEAK movement analysis system and vertical ground reaction force by a force plate. A two-way repeated measures analysis of variance showed that neither therapeutic tape nor control tape had any effect on the EMG VMO-VL onset timing difference. Therapeutic tape, but not control tape, led to significant increases in stance phase knee flexion. The first peak vertical ground reaction force was lowered by both control and therapeutic tape but only during fast walking. The results suggest that tape induced effects on neuromotor control of the vasti seen in other studies are related to reductions in pain rather than the presence of a baseline timing deficit. However, this cannot explain the improvements in stance phase knee flexion observed with tape. ß

show abstract

Section: Effect Of Patellar Tapingmentioning

confidence: 86%

Effect of patellar taping on vasti onset timing, knee kinematics, and kinetics in asymptomatic individuals with a delayed onset of vastus medialis oblique

2006

View full text Add to dashboard Cite

show abstract

“…[24][25][26][27][28][29] This inhibitory effect of experimental pain, however, was not observed by Romaniello et al 30 Changes in responses evoked by TMS do not necessarily reflect changes at the motorcortex level; alternatively, they could be the result of changes occurring in various neural structures between the primary motor cortex and the motoneurons in the spinal cord. However, there is evidence that the origin of these effects can be at least partially attributed to the cortex.…”

Section: Does Acute Pain Interfere With Motor-cortex Activity?mentioning

confidence: 99%

“…For example, laser-evoked pain was found to attenuate motor responses to TMS but not to transcranial electrical anodal stimulation (which directly activates the pyramidal tract rather than activating cortical interneurons). 24,27 Another study showed that during the initial phase of tonic pain induced by injection of hypertonic (5%) saline, there was a reduction of motor responses evoked by TMS stimulation in the absence of any effect on the H-reflex (H-reflex amplitude was decreased in a later phase, about 1 minute after the peak in pain, which suggests that the change initially occurred at the motor-cortex level). 25 Pain induced by application of capsaicin on the skin was also found to reduce the amplitude of motor responses evoked by TMS without alteration of spinal excitability.…”

Section: Does Acute Pain Interfere With Motor-cortex Activity?mentioning

confidence: 99%

“…33,34 Even though nociceptive inputs from muscle and skin have been shown to induce distinct changes in trigeminal motoneuronal excitability, 35 changes at the motor-cortex level appear to be consistently inhibitory across the different pain models (muscle vs. cutaneous pain, phasic vs. tonic pain). [24][25][26][27][28][29] In patients with motor deficits who experience acute pain, the inhibitory influence of pain on the motor cortex may hamper optimal motor-cortex activation during voluntary movement and preclude motor improvement during rehabilitation. There is striking evidence supporting this view from a recent study in healthy individuals showing that acute pain can prevent motor-cortex plasticity associated with novel motor training and impair the ability to learn a new motor task.…”

Section: Does Acute Pain Interfere With Motor-cortex Activity?mentioning

confidence: 99%

See 1 more Smart Citation

Interactions between Pain and the Motor Cortex: Insights from Research on Phantom Limb Pain and Complex Regional Pain Syndrome

Mercier

Léonard²

2011

Physiotherapy Canada

View full text Add to dashboard Cite

Purpose: Pain is a significantly disabling problem that often interacts with other deficits during the rehabilitation process. The aim of this paper is to review evidence of interactions between pain and the motor cortex in order to attempt to answer the following questions: (1) Does acute pain interfere with motorcortex activity? (2) Does chronic pain interfere with motor-cortex activity, and, conversely, does motor-cortex plasticity contribute to chronic pain? (3) Can the induction of motor plasticity by means of motor-cortex stimulation decrease pain? (4) Can motor training result in both motor-cortex reorganization and pain relief? Summary of Key Points: Acute experimental pain has been clearly shown to exert an inhibitory influence over the motor cortex, which can interfere with motor learning capacities. Current evidence also suggests a relationship between chronic pain and motor-cortex reorganization, but it is still unclear whether one causes the other. However, there is growing evidence that interventions aimed at normalizing motor-cortex organization can lead to pain relief. Conclusions: Interactions between pain and the motor cortex are complex, and more studies are needed to understand these interactions in our patients, as well as to develop optimal rehabilitative strategies.Key Words: motor control, motor cortex, pain, plasticity, rehabilitation RÉ SUMÉObjectif : La douleur est considé rablement invalidante et pré sente souvent des interactions avec d'autres dé ficits au cours du processus de ré adaptation. L'objectif de cet article est d'analyser donné e supportant la pré sence d'interactions entre la douleur et le cortex moteur afin de tenter de ré pondre aux questions suivantes : (1) La douleur aiguë nuit-elle à l'activité du cortex moteur? (2) La douleur chronique altè re-t-elle l'activité du cortex moteur et, ré ciproquement, la ré organisation du cortex moteur contribue-t-elle à la douleur chronique? (3) L'induction de la plasticité motrice par stimulation du cortex moteur peut-elle ré duire la douleur? (4) L'entraînement moteur peut-il amener à la fois une ré organisation du cortex moteur et un soulagement de la douleur? Ré sumé des principaux points : Il a é té clairement dé montré que la douleur aiguë expé rimentale exerce une influence inhibitoire sur le cortex moteur, qui peut entraver les capacité s d'apprentissage moteur. Les donné e actuelles suggè rent é galement qu'il existe une relation entre la douleur chronique et la ré organisation du cortex moteur, mais il n'est pas clair que l'un provoque l'autre. Il existe toutefois des preuves de plus en plus nombreuses que les interventions visant à normaliser l'organisation du cortex peuvent amener un soulagement de la douleur. Conclusions : Les interactions entre la douleur et le cortex moteur sont complexes et d'autres é tudes sont né cessaires pour comprendre ces interactions chez nos patients et pour concevoir des straté gies de ré adaptation optimales.

show abstract

“…Neurophysiological reviews on nociception-motor interactions (Hodges et al 2013;Hodges and Tucker 2011;Nijs et al 2012) indicate that nociceptive stimuli result in cortical transmission of the motor output and affect the activity of the painful muscle. Nociception impairs motor output through central mechanisms: activated neurons in the somatosensory cortex produce a pain-dependent inhibitory input to the primary motor cortex (both ipsilateral and contralateral) (Farina et al 2001;Valeriani et al 1999), and tonic muscle nociception results in long-lasting inhibition of the primary motor cortex (Le Pera et al 2001). Motor cortex inhibition occurs immediately in response to pain, but it fades once levels of perceived pain become stable for a given amount of time and when no further increase in pain perception is expected by the patient (Farina et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Influence of shoulder pain on muscle function: implications for the assessment and therapy of shoulder disorders

et al. 2014

View full text Add to dashboard Cite

Shoulder pain is often a challenging clinical phenomenon because of the potential mismatch between pathology and the perception of pain. Current evidence clearly emphasizes an incomplete understanding of the nature of shoulder pain. Indeed, the effective diagnosis and treatment of shoulder pain should not only rely upon a detailed knowledge of the peripheral pathologies that may be present in the shoulder, but also on current knowledge of pain neurophysiology. To assess and treat shoulder pain, a comprehensive understanding of the way in which pain is processed is essential. This review reflects modern pain neurophysiology to the shoulder and aims to answer the following questions: why does my shoulder hurt? What is the impact of shoulder pain on muscle function? What are the implications for the clinical examination of the shoulder? And finally, what are the clinical implications for therapy? Despite the increasing amount of research in this area, an in-depth understanding of the bidirectional nociception-motor interaction is still far from being achieved. Many questions remain, especially related to the treatment of nociception-motor interactions

show abstract

Inhibition of the human primary motor area by painful heat stimulation of the skin

Cited by 112 publications

References 43 publications

Effect of patellar taping on vasti onset timing, knee kinematics, and kinetics in asymptomatic individuals with a delayed onset of vastus medialis oblique

Effect of patellar taping on vasti onset timing, knee kinematics, and kinetics in asymptomatic individuals with a delayed onset of vastus medialis oblique

Interactions between Pain and the Motor Cortex: Insights from Research on Phantom Limb Pain and Complex Regional Pain Syndrome

Influence of shoulder pain on muscle function: implications for the assessment and therapy of shoulder disorders

Contact Info

Product

Resources

About