Inhibition of the hepatic glucose output is responsible for the hypoglycemic effect of Crataegus aronia against type 2 diabetes mellitus in rats

Mostafa, Dalia G.; Khaleel, Eman F.; Abdel-Aleem, Ghada A.

doi:10.2298/abs170510044m

Cited by 8 publications

(7 citation statements)

References 55 publications

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“…C. aronia significantly improved the oral glucose tolerance test, lowered plasma glucose, serum lipid levels and the hepatic glycogen content. In addition, it significantly lowered the levels of hepatic lipid peroxidation, TNF-α and IL-6, while the level of reduced glutathione (GSII) was enhanced and SOD activity was increased (Mostafa et al, 2018). Regarding the mechanism involved, it enhanced hepatic mRNA expression of the insulin receptor A isoform (IR-A) and glucose 6-phosphatase (G6Pase), while the expression of glucose transporter-2 (GLUT-2) and glycerol kinase (GK) mRNA was lowered.…”

Section: Hypoglycemic Effectsmentioning

confidence: 99%

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Venskutonis¹

2018

JFB

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Hawthorn (Crataegus spp.) is one of the most famous plants which has been used as natural medicine and nutraceutical. Its phytochemical composition, bioactive compounds and health benefits have been intensively studied and hawthorn preparations may be recognized as classical natural products for cardiovascular health. Polyphenolic compounds of different hawthorn anatomical parts as well as their extracts have been the focus of a majority of these studies, although various other classes of natural health promoting constituents have also been isolated, identified and characterized. Regardless, numerous published reports have particularly focused on the activity mechanisms which are very important for supporting various health benefits. This review summarizes the most recent studies on hawthorn, mainly published since 2015. Search of different databases indicates that approximately 200 publications, which are relevant to phytochemistry and health benefits of Crataegus spp., have appeared since then, most of them have not been included in the existing reviews.

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Section: Hypoglycemic Effectsmentioning

confidence: 99%

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Venskutonis¹

2018

JFB

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“…The serum levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) were increased in T2DM. As indicated in Table 1 , Crataegus aronia application at the dose of 500 mg/kg/orally for 60 days significantly reversed all aforementioned alterations to near normal, evidently through hawthorn-mediated antioxidant and anti-inflammatory actions in diabetic rats [ 59 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

Molecular Mechanisms of Hawthorn Extracts in Multiple Organs Disorders in Underlying of Diabetes: A Review

Gheitasi

Savari

Akbari

et al. 2022

International Journal of Endocrinology

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Diabetes mellitus (DM) is one of the most important metabolic disorders associated with chronic hyperglycemia and occurs when the body cannot manage insulin secretion, insulin action, or both. Autoimmune destruction of pancreatic beta cells and insulin resistance are the major pathophysiological factors of types 1 and 2 of DM, respectively. Prolonged hyperglycemia leads to multiple organs dysfunctions, including nephropathy, neuropathy, cardiomyopathy, gastropathy, and micro- and macrovascular disorders. The basis of the metabolic abnormalities in carbohydrate, fat, and protein in diabetes is insufficient action of insulin on various target tissues. Medicinal plants are rich sources of bioactive chemical compounds with therapeutic effects. The beneficial effects of leaves, fruits, and flowers extracts of Crataegus oxyacantha, commonly called hawthorn, belonging to the Rosaceae family, are widely used as hawthorn-derived medicines. Data in this review have been collected from the scientific articles published in databases such as Science Direct, Scopus, PubMed, Web of Science, and Scientific Information Database from 2000 to 2021. Based on this review, hawthorn extracts appear both therapeutic and protective effects against diabetic-related complications in various organs through molecular mechanisms, such as decreasing triglyceride, cholesterol, very low density lipoprotein and increasing the antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity, decreasing malondialdehyde level, and attenuating tumor necrosis factor alpha, interleukin 6 and sirtuin 1/AMP-activated protein kinase (AMPK)/nuclear factor kappa B (NF-κB) pathway and increasing the phosphorylation of glucose transporter 4, insulin receptor substrate 1, AKT and phosphoinositide 3-kinases, and attenuating blood sugar and regulation of insulin secretion, insulin resistance, and improvement of histopathological changes in pancreatic beta cells. Collectively, hawthorn can be considered as one new target for the research and development of innovative drugs for the prevention or treatment of DM and related problems.

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“…A synergistic effect of antidiabetic and antioxidant activity was reported for the C. aronia extract of the whole plant. It was thought that the plant works through the inhibition of hepatic insulin resistance without affecting blood insulin level [ 155 ].…”

Section: Medicinal Plants With Potential Antidiabetic Activity In mentioning

confidence: 99%

Middle East Medicinal Plants in the Treatment of Diabetes: A Review

Abu-Odeh

Talib

2021

Molecules

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Diabetes is a global health problem, and the number of diabetic patients is in continuous rise. Conventional antidiabetic therapies are associated with high costs and limited efficiency. The use of traditional medicine and plant extracts to treat diabetes is gaining high popularity in many countries. Countries in the Middle East region have a long history of using herbal medicine to treat different diseases, including diabetes. In this review, we compiled and summarized all the in vivo and in vitro studies conducted for plants with potential antidiabetic activity in the Middle East region. Plants of the Asteraceae and Lamiaceae families are the most investigated. It is hoped that this review will contribute scientifically to evidence the ethnobotanical use of medicinal plants as antidiabetic agents. Work has to be done to define tagetes, mechanism of action and the compound responsible for activity. In addition, safety and pharmacokinetic parameters should be investigated.

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Inhibition of the hepatic glucose output is responsible for the hypoglycemic effect of Crataegus aronia against type 2 diabetes mellitus in rats

Abstract: How to cite this article: Mostafa DG, Khaleel EF, Abdel-Aleem GA. Inhibition of the hepatic glucose output is responsible for the hypoglycemic effect of Crataegus aronia against type 2 diabetes mellitus in rats.

Cited by 8 publications

References 55 publications

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Molecular Mechanisms of Hawthorn Extracts in Multiple Organs Disorders in Underlying of Diabetes: A Review

Middle East Medicinal Plants in the Treatment of Diabetes: A Review

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