Middle East Medicinal Plants in the Treatment of Diabetes: A Review

Abu-Odeh, Alaa; Talib, Wamidh H.

doi:10.3390/molecules26030742

Cited by 43 publications

(26 citation statements)

References 301 publications

(153 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The best result from reduction of phosphoenolpyruvate carboxykinase (PEPCK) activity (84.0%) and increasing hepatic glycogen phosphorylase (GP) activity (134.5%) points of view was related to the aqueous extract comparing with those of glibenclamide (62.5% and 133.0%), respectively. C. bruguierana depicted no effect on blood insulin, but it was able to reduce blood glucose by stimulation of hepatic glycogenolysis and inhibition of gluconeogenesis [ 77 , 104 ].…”

Section: Resultsmentioning

confidence: 99%

“…Chlorogenic acid has chemopreventive and hypoglycemic effects [ 150 ], and it is the main component of medicinal plants characterized by their antioxidant, anti-inflammatory, and enzyme inhibitory activities [ 150 , 189 , 228 ]. C. bruguierana possessed sesquiterpene lactones and flavonoids (kaempferol, rutin, and quercetin) [ 77 , 104 , 120 ]. Also, the plant has been documented for its antiplasmodial and antipeptic ulcer effects [ 77 , 229 , 230 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Fattaheian-Dehkordi

Hojjatifard

Saeedi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. Diabetes mellitus (DM) is a long-life metabolic disorder, characterized by high blood glucose levels. The hyperglycemic condition generally leads to irreversible nerve injury and vascular damage. Among different types of diabetes, type 2 is more common and has spread all over the world. Although various therapeutic approaches have been developed to control type 2 DM, regulating blood glucose levels has still remained a controversial challenge for patients. Also, most prescription drugs cause different side effects, such as gastrointestinal disorders. Thus, developing novel and efficient antidiabetic agents possessing fewer adverse effects is in high demand. Method. The literature was comprehensively surveyed via search engines such as Google Scholar, PubMed, and Scopus using appropriate keywords. Results. Medicinal plants, both extracts and isolated active components, have played a significant role in controlling the blood glucose levels. Good-to-excellent results documented in the literature have made them a precious origin for developing and designing drugs and supplements against DM. Centaurea spp. have been traditionally used for controlling high blood glucose levels. Also, the antidiabetic properties of different species of Centaurea have been confirmed in recent studies through in vitro assays as well as in vivo experiments. Conclusion. Potent results encouraged us to review their efficacy to open a new horizon for development of herbal antidiabetic agents.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Fattaheian-Dehkordi

Hojjatifard

Saeedi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Plants' anti-hyperglycemic properties are mainly related to their ability to improve the performance of pancreatic tissue, which is accomplished by elevating insulin secretions or limiting glucose absorption in the intestine [16,21,22]. The number of people living with diabetes is rising, creating concerns among medical professionals and the general population.…”

Section: Anti-diabetic Effect Of Medicinal Plantsmentioning

confidence: 99%

A Review on the Antidiabetic Potential of Medicinal Plants

Bushnak¹,

Hajj²,

Jaber³

2021

SJMH

View full text Add to dashboard Cite

Diabetes mellitus has long been seen as a substantial economic burden on patients, their families, and society. Impairment in blood sugar regulation has major health repercussions. Furthermore, untreated diabetes causes major chronic complications like blindness, renal failure, and heart failure, as well as an increase in associated mortality. New anti-diabetic medicines are being researched to help alleviate this issue. Conventional Anti-diabetic medications are beneficial, several synthetic drugs are available in the market to treat diabetes, but they are costly and come with inevitable adverse effects. Medicinal plants, on the other hand, may serve as an alternate source of anti-diabetic agents. According to the World Health Organization, 80 % of the population in underdeveloped nations still relies on traditional medicines or folk medicines, which are largely made from plants, for disease prevention or treatment. For instance, anti- proliferative, anti-viral, anti-inflammatory and anti-hyperglycemic effects. In order to find a natural anti-diabetic source that comes with less side effects, several studies have been conducted. The aim of this work is to review these studies and highlight the potential of plants when it comes to their anti-diabetic effect.

show abstract

“…Moringa peregrina has diverse traditional, medicinal, industrial, spiritual, and religious values [48]. In Folk medicine, different plant parts have been recruited for different medicinal purposes, including diabetes, hypertension, wound healing and skin problems, fever, and many other reported uses [49][50][51]. It was reported that Persian M. peregrina (Forssk.)…”

Section: E Moringa Peregrina (Forssk) Fiorimentioning

confidence: 99%

DNA Barcoding of Selected Medicinal Plant Species from Jordan Using matK, rbcL, and rpoC1 Genes

Alkaraki

Aldmoor

Lahham

et al. 2021

International Journal of Biology and Biomedical Engineering

View full text Add to dashboard Cite

Medicinal plants play an essential role in preventing and treating several diseases. Classical taxonomic tools generally carry out medicinal plant identification and characterization. Unfortunately, conventional methods need well-trained taxonomists and could give a false identity for closely related species. Jordanian flora is rich in a variety of plant species. The phylogeographic architecture of Jordanian medicinal plant samples was not explored yet. This study aims to recruit DNA barcoding using matK, rbcL, and rpoC1 genes to identify different selected medicinal plants species from Jordan. These are Maerua crassifolia, Ziziphus spina-christi, Balanites aegyptiaca, Senna italica, and Moringa peregrina. Plant samples were collected from the Dead Sea area (Jordan), and three DNA barcode regions were amplified, sequenced, and analyzed using different bioinformatic tools. Twelve sequences were obtained and deposited in Genbank . These sequences showed a very good discrimination capacity with sequences retrieved from related species. The phylogenetic analysis illustrated that DNA barcoding could successfully identify the selected medicinal plant species using different chloroplast genes (rbcL, matK, and rpoC1). Further analysis for other plants species is recommended to explore the genetic relationship and the phylogeographic architecture for Jordanian flora.

show abstract

Middle East Medicinal Plants in the Treatment of Diabetes: A Review

Cited by 43 publications

References 301 publications

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

A Review on the Antidiabetic Potential of Medicinal Plants

DNA Barcoding of Selected Medicinal Plant Species from Jordan Using matK, rbcL, and rpoC1 Genes

Contact Info

Product

Resources

About