Inhibition of the development of experimental tumors of the cervix and vagina by tinctures from biomass of cultured ginseng cells and its germanium-selective stocks

Беспалов, В. Г.; Давыдов, В. В.; Limarenko, A. Yu.; Slepyan, Leonid I.; Александров, В. А.

doi:10.1007/bf00805166

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…When taken, 4 yr-old fresh or white ginseng did not show any anticarcinogenicity in animal model (30,31), and an epidemiological study also revealed no statistically significant reduction of the relative risk in human (83)(84)(85). When heated, however, these ginsengs were highly effective as anticarcinogenic agents and these results were confirmed by others (33)(34)(35)(36)(37)(38). Red ginseng extract in a two-stage carcinogenesis mouse model had a significant inhibitory effect on skin cancer formation.…”

Section: Identification Of Active Anticarcino-genic Components In Redmentioning

confidence: 72%

“…Tissue-culture biomass tincture obtained from cultured Panax ginseng cells has a strong inhibitory effect on the development of rat mammary adenocarcinoma induced by methyl-N-nitrosourea administration (34) and experimental uterine cervix and vaginal tumors (35). Red ginseng extracts had a significant inhibitory effect on skin cancer formation in a two-stage carcinogenesis mouse model: red ginseng extract at 50-400 mg/kg inhibited the development of skin papillomas induced by DMBA and croton oil in mice, decreased in the incidence, prolonged the latent period before tumor occurrence, and reduced tumor number per mouse in a dose-dependent manner (36).…”

Section: Supportive Anticarcinogenic Effects Of Panax Ginseng Ca Mementioning

confidence: 99%

“…It should be noted here that Chinese (33,36), Russian (34,35), Korean (37) and Japanese (38) scientists only recently began to concentrate their effort on the cancer-preventive rather than the general effects of ginseng.…”

Section: Supportive Anticarcinogenic Effects Of Panax Ginseng Ca Mementioning

confidence: 99%

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Anticarcinogenic Effect of Panax ginseng C.A. Meyer and Identification of Active Compounds

Yun¹,

Lee²,

Lee³

et al. 2001

J Korean Med Sci

204

136

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The failure to improve the five-year survival rate of cancer patients, from one in three in the 1960s to one in two in the 1970s, stimulated awareness of the importance of primary prevention of cancer. Korean investigators carried out extensive long-term anticarcinogenicity experiments with 2000 newborn mice to investigate whether Panax ginseng C.A. Meyer inhibited carcinogenesis induced by several chemical carcinogens in 1978. There was a 22% decrease (p <0.05) in the incidence of urethane induced lung adenoma by the combined use of red ginseng extract. In the group sacrificed at 56 weeks after the treatment with aflatoxin B1, the incidence of hepatoma significantly decreased to 75% by the addition of red ginseng extract (p <0.05). The result showed that natural products can provide hope for human cancer prevention. By the newly established '9 week mediumterm anticarcinogenicity test model of lung tumors in mice' (Yun' s model), we confirmed significant anticarcinogenic effects of powders and extracts of the 6-yr-old dried fresh ginseng, 5-and 6-yr old white ginsengs, and 4-, 5-, and 6-yr old red ginseng. We also demonstrated that the anticarcinogencity of ginseng was more prominent in aged or heat treated extracts of ginseng and red ginseng made by steaming. To investigate the active components for cancer prevention, several fractions of 6-yr old fresh ginseng and red ginseng, four semi-synthetic ginsenoside Rh1, Rh2, Rg3 and Rg5, major saponin components in red ginseng, were prepared. Among the ginsenosides, Rg3 and Rg5 showed statistically significant reduction of lung tumor incidence and Rh2 had a tendency of decreasing the incidence. Ginsenoside Rg3, Rg5 and Rh2 were found to be active anticarcinogenic compounds. Rg3, Rg5 and Rh2 are active components in red ginseng, and they prevent cancer either singularly or synergistically.

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Section: Identification Of Active Anticarcino-genic Components In Redmentioning

confidence: 72%

Section: Supportive Anticarcinogenic Effects Of Panax Ginseng Ca Mementioning

confidence: 99%

See 1 more Smart Citation

Anticarcinogenic Effect of Panax ginseng C.A. Meyer and Identification of Active Compounds

Yun¹,

Lee²,

Lee³

et al. 2001

J Korean Med Sci

204

136

View full text Add to dashboard Cite

show abstract

“…In Russia, tissue-culture biomass tincture obtained from cultured Panax ginseng cells was shown to have a strong inhibitory effect on rat mammary adenocarcinoma induced by methyl-N-nitrosourea (27) as well as development of experimental uterine cervix and vaginal tumors (28). The result that 12-o-tetradecanoylphorbol-13-acetate (TPA)-induced production of tumor necrosis factor in mouse skin was inhibited by methanol extract of heat-processed neoginseng pretreatment was obtained in Korea (29).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Study on Cancer Prevention by Ginseng: Are All Kinds of Cancers Preventable by Ginseng?

Yun¹,

Choi²,

Yun³

2001

J Korean Med Sci

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In the light of experimental results, two case-control studies and one cohort study in a population of ginseng cultivation area were conducted to confirm whether ginseng has any anticarcinogenic effect on human cancers. All participants were interviewed using a standardised questionnaire to obtain the information on demographics, cigarette smoking, alcohol consumption and ginseng intake. In 905 pairs case-control study, 62% had a history of ginseng intake compared to 75% of the controls, a statistically significant difference (p<0.01). The odds ratio (OR) for cancer in relation to ginseng intake was 0.56. In extended case-control study with 1987 pairs, the ORs for cancer were 0.37 in fresh ginseng extract users, 0.57 in white ginseng extract users, 0.30 in white ginseng extract users, 0.30 in white ginseng powder users, and 0.20 in red ginseng users. Those who took fresh ginseng slices, fresh ginseng juice, and white ginseng tea, however, did not show decrease in the risk. Overall, the risk decreased as the frequency and duration of ginseng intake increased. With respect to the site of cancer, the ORs for cancers of the lip, oral cavity, pharynx, esophagus, stomach, colorectum, liver, pancreas, larynx, lung and ovary were significantly reduced by ginseng intake. Smokers with ginseng intake showed lower ORs for cancers of lung, lip, oral cavity and pharynx and liver than those without ginseng intake. In 5 yr follow- up cohort study conducted in the ginseng cultivation area, Kangwha-eup, ginseng intakers had significantly lower risk than non-intakers. As for the type of ginseng, cancer risk significantly decreased among intakers of fresh ginseng extract, alone or together with other ginseng preparations. Among 24 red ginseng intakers, no cancer death occurred during the follow-up period. The risk for stomach and lung cancers was significantly reduced by ginseng intake, showing a statistically significant dose-response relationship in each follow-up year. In conclusion, Panax ginseng C.A. Meyer has been established as non-organ specific cancer preventive, having dose response relationship. These results warrant that ginseng extracts and its synthetic derivatives should be examined for their preventive effect on various types of human cancers.

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Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds

Yun

2003

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

163

111

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Inhibition of the development of experimental tumors of the cervix and vagina by tinctures from biomass of cultured ginseng cells and its germanium-selective stocks

Cited by 5 publications

References 6 publications

Anticarcinogenic Effect of Panax ginseng C.A. Meyer and Identification of Active Compounds

Anticarcinogenic Effect of Panax ginseng C.A. Meyer and Identification of Active Compounds

Epidemiological Study on Cancer Prevention by Ginseng: Are All Kinds of Cancers Preventable by Ginseng?

Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds

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