Inhibition of <i>Staphylococcus aureus α</i>‐Hemolysin Production Using Nanocurcumin Capped Au@ZnO Nanocomposite

Jabir, Majid S.; Rashid, Taha M.; Nayef, Uday M.; Albukhaty, Salim; AlMalki, Faizah A.; Albaqami, Jawaher; Alyamani, Amal; Taqi, Zainab J.; Sulaiman, Ghassan M.

doi:10.1155/2022/2663812

Cited by 75 publications

(36 citation statements)

References 78 publications

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“…The antibacterial susceptibility of Ocimum sanctum leaf and Bi-TiO 2 nanoparticles is assessed using the disc diffusion technique. The antibacterial capabilities of tulsi extract and Bi-TiO 2 nanoparticles were investigated using Gram-positive and Gram-negative bacteria as model microorganisms, such as E. coli and S. aureus [ 23 ]. To prepare the nutritional agar plate, all glassware is sterilized in a 120°C autoclave for 30 minutes.…”

Section: Methodsmentioning

confidence: 99%

[Retracted] Molecular Docking and Green Synthesis of Bioinorganic TiO2 Nanoparticles against E.coli and S.aureus

Al-Serwi

El-Sherbiny

Kumar³

et al. 2022

Bioinorganic Chemistry and Applications

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This study used a simple solution evaporation approach to make a bioinorganic titanium dioxide (Bi-TiO2) photocatalyst for dye contaminant degradation. A variety of techniques, including X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) coupled with energy dispersive X-ray analysis (EDAX), and differential reflectance spectroscopy, had been employed to classify the structural and optical properties of the prepared bioinorganic photocatalyst (UV-DRS). Using simulated solar irradiation, the photocatalytic activity of the produced Bi-TiO2 nanoparticles was examined by detecting the degradation of a solution of methylene blue (MB) as a model dye molecule. The developed Bi-TiO2 photocatalyst demonstrates superior photocatalytic action than commercially available powder TiO2, according to photo-degradation experiments. E.coli and S.aureus bacterial strains were employed to assess the antibacterial activity of Bi-TiO2 nanoparticles. The most active molecules that gain antibacterial activity were examined in isolated or extracted components from the tulsi plant. The chosen compounds were docked with thymidylate kinase (TMPK), a potential therapeutic goal for the preparation of novel antibacterial drugs with the PDB ID of 4QGG. Five compounds, namely rosmarinic acid, vicenin-2, orientin, vitexin, and isoorientin, out of the 27 chosen compounds, showed a higher docking score and may aid in boosting antibacterial activity. The synthesized Bi-TiO2 nanoparticles produced antibacterial activity that was effective against Gram-positive bacteria. The nanomaterials that have been synthesized have a lot of potential in wastewater treatment and biomedical management technologies.

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Section: Methodsmentioning

confidence: 99%

[Retracted] Molecular Docking and Green Synthesis of Bioinorganic TiO2 Nanoparticles against E.coli and S.aureus

Al-Serwi

El-Sherbiny

Kumar³

et al. 2022

Bioinorganic Chemistry and Applications

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“…Apart from their antibacterial, antioxidant, cytotoxic, hemolytic, and antiviral properties, ZnO NPs have many other biological and medicinal applications [ 123 ]. It has been reported that cancer was identified as the second most common cause of dysphoria in humans, after cardiovascular diseases [ 124 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Recent Advances in Plant-Mediated Zinc Oxide Nanoparticles with Their Significant Biomedical Properties

et al. 2022

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Compared to traditional physical and chemical approaches, nanobiotechnology and plant-based green synthesis procedures offer significant advantages, as well as having a greater range of medical and biotechnological applications. Nanoparticles of zinc oxide (ZnO NPs) have recently been recognized as a promising option for many industries, including optics, electrics, packaged foods, and medicine, due to their biocompatibility, low cytotoxicity, and cost-effectiveness. Several studies have shown that zinc ions are important in triggering cell apoptosis by promoting the generation of reactive oxygen species (ROSs) and releasing zinc ions (Zn2+), which are toxic to cells. The toxic nature of the chemicals used in the synthesis of ZnO nanoparticles limits their clinical utility. An overview of recent developments in green ZnO NP synthesis is presented in this review, emphasizing plant parts as reducing agents and their medical applications, including their antimicrobial, anticancer, antioxidant, and anti-inflammatory properties, as well as key mechanisms of action for these applications to facilitate further research on the biomedical fields in the future.

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“…The chemical features of BC-CuONPs were recorded by FTIR (Bruker Tensor 27, Biotage, Germany; scanning range of 4000–400 cm −1 ; resolution of 4 cm −1 in the transmittance mode). The dried powder of biosynthesized CuONPs powder was mixed with potassium bromide and pressed into the disc for FTIR analysis 39 , 40 . The chemical composition of oxide CuONPs was analyzed by a X-ray photoelectron spectroscopy (XPS) analyzer (BESTEC, Germany) 41 , 42 .…”

Section: Methodsmentioning

confidence: 99%

Biogenic copper oxide nanoparticles from Bacillus coagulans induced reactive oxygen species generation and apoptotic and anti-metastatic activities in breast cancer cells

Dolati

Tafvizi

Salehipour

et al. 2023

Sci Rep

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The present study examined the anticancer capabilities of Bacillus coagulans supernatant-produced copper oxide nanoparticles (BC-CuONPs) on MCF-7 and SKBR3 cancer cells. The X-ray diffraction, ultraviolet–visible spectroscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, field-emission scanning electron microscopy, energy-dispersive X-ray, dynamic light scattering, and zeta potential techniques were used to characterize BC-CuONPs. This study also investigated the cellular and molecular processes of NPs’ anti-proliferative and apoptotic properties on human breast cancer cells and compared them to the commercial pharmaceutical tamoxifen. The size of the spherical NP was from 5 to 47 nm with negative zeta potential. The MTT results showed the great cytotoxic effect of BC-CuONPs against breast cancer cells. The BC-CuONPs inhibited the growth of breast cancer cells in a time- and dose-dependent manner. The up-regulation of BCL2-associated X (BAX), cyclin dependent kinase inhibitor 1A (P21), Caspase 3 (CASP3), and Caspase 9 (CASP9), the down-regulation of BCL2 apoptosis regulator (BCL2), Annexin V-FITC/propidium iodide, and reactive oxygen species (ROS) generation results suggested that BC-CuONPs had a significant apoptotic impact when compared to the control. Scratch tests and vascular endothelial growth factor receptor gene (VEGF) down-regulation demonstrated that BC-CuONPs had anti-metastatic activity. The cell cycle analysis and down-regulation of Cyclin D1 (CCND1) and cyclin dependent kinase 4 (CDK4) revealed that cancer cells were arrested in the sub-G1 phase. Finally, the results showed that the secondary metabolites in the supernatant of Bacillus coagulans could form CuONPs, and biogenic BC-CuONPs showed anti-metastasis and anticancer properties on breast cancer cells while having less adverse effects on normal cells. Therefore, the synthesized CuONPs using B. coagulans supernatant can be shown as a potential candidate for a new therapeutic strategy in cancer management.

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Inhibition of Staphylococcus aureus α‐Hemolysin Production Using Nanocurcumin Capped Au@ZnO Nanocomposite

Cited by 75 publications

References 78 publications

[Retracted] Molecular Docking and Green Synthesis of Bioinorganic TiO2 Nanoparticles against E.coli and S.aureus

[Retracted] Molecular Docking and Green Synthesis of Bioinorganic TiO2 Nanoparticles against E.coli and S.aureus

Recent Advances in Plant-Mediated Zinc Oxide Nanoparticles with Their Significant Biomedical Properties

Biogenic copper oxide nanoparticles from Bacillus coagulans induced reactive oxygen species generation and apoptotic and anti-metastatic activities in breast cancer cells

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